Mutant p53–Nrf2 axis regulates the proteasome machinery in cancer
The proteasome machinery is a common target of gain-of-function p53 missense mutants. Upregulation of the proteasome fosters chemoresistance to proteasome inhibitors. In triple negative breast cancer cells this resistance mechanism, namely the Nrf2-regulated “bounce-back” response to proteasome inhi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-01-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2016.1217967 |
| _version_ | 1797677213410131968 |
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| author | Kamil Lisek Dawid Walerych Giannino Del Sal |
| author_facet | Kamil Lisek Dawid Walerych Giannino Del Sal |
| author_sort | Kamil Lisek |
| collection | DOAJ |
| description | The proteasome machinery is a common target of gain-of-function p53 missense mutants. Upregulation of the proteasome fosters chemoresistance to proteasome inhibitors. In triple negative breast cancer cells this resistance mechanism, namely the Nrf2-regulated “bounce-back” response to proteasome inhibitors, can be overcome by targeting p53 mutant proteins with APR-246/PRIMA-1Met. |
| first_indexed | 2024-03-11T22:41:51Z |
| format | Article |
| id | doaj.art-6a28fa74ac2547b7a90b5a7ce7caddee |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:51Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-6a28fa74ac2547b7a90b5a7ce7caddee2023-09-22T09:10:57ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562017-01-014110.1080/23723556.2016.12179671217967Mutant p53–Nrf2 axis regulates the proteasome machinery in cancerKamil Lisek0Dawid Walerych1Giannino Del Sal2Laboratorio Nazionale CIB, Area Science Park PadricianoLaboratorio Nazionale CIB, Area Science Park PadricianoLaboratorio Nazionale CIB, Area Science Park PadricianoThe proteasome machinery is a common target of gain-of-function p53 missense mutants. Upregulation of the proteasome fosters chemoresistance to proteasome inhibitors. In triple negative breast cancer cells this resistance mechanism, namely the Nrf2-regulated “bounce-back” response to proteasome inhibitors, can be overcome by targeting p53 mutant proteins with APR-246/PRIMA-1Met.http://dx.doi.org/10.1080/23723556.2016.1217967apr-246cancerchip-seqkeap1multi-omicsmutant p53nrf2proteasometnbctranscriptomicsproteomics |
| spellingShingle | Kamil Lisek Dawid Walerych Giannino Del Sal Mutant p53–Nrf2 axis regulates the proteasome machinery in cancer Molecular & Cellular Oncology apr-246 cancer chip-seq keap1 multi-omics mutant p53 nrf2 proteasome tnbc transcriptomics proteomics |
| title | Mutant p53–Nrf2 axis regulates the proteasome machinery in cancer |
| title_full | Mutant p53–Nrf2 axis regulates the proteasome machinery in cancer |
| title_fullStr | Mutant p53–Nrf2 axis regulates the proteasome machinery in cancer |
| title_full_unstemmed | Mutant p53–Nrf2 axis regulates the proteasome machinery in cancer |
| title_short | Mutant p53–Nrf2 axis regulates the proteasome machinery in cancer |
| title_sort | mutant p53 nrf2 axis regulates the proteasome machinery in cancer |
| topic | apr-246 cancer chip-seq keap1 multi-omics mutant p53 nrf2 proteasome tnbc transcriptomics proteomics |
| url | http://dx.doi.org/10.1080/23723556.2016.1217967 |
| work_keys_str_mv | AT kamillisek mutantp53nrf2axisregulatestheproteasomemachineryincancer AT dawidwalerych mutantp53nrf2axisregulatestheproteasomemachineryincancer AT gianninodelsal mutantp53nrf2axisregulatestheproteasomemachineryincancer |