Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo.

Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo.

Loss of function mutations of Kif7, the vertebrate orthologue of the Drosophila Hh pathway component Costal2, cause defects in the limbs and neural tubes of mice, attributable to ectopic expression of Hh target genes. While this implies a functional conservation of Cos2 and Kif7 between flies and ve...

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Main Authors: Ashish Kumar Maurya, Jin Ben, Zhonghua Zhao, Raymond Teck Ho Lee, Weixin Niah, Ashley Shu Mei Ng, Audrey Iyu, Weimiao Yu, Stone Elworthy, Fredericus J M van Eeden, Philip William Ingham
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3854788?pdf=render

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