Results of the study of the immunogenic activity of cell envelopes of Francisella tularensis different subspicies (Report 2)
The effect of cell envelopes preparations of four subspecies of Francisella tularensis, derived from urea lysates of tularemia microbe on cytokine production by immunocompetent cells of experimental animals has been studied. Stimulating influence of F. tularensis cell envelopes preparations on cytok...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Scientific Сentre for Family Health and Human Reproduction Problems
2015-02-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/13 |
| _version_ | 1797237483341086720 |
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| author | A. V. Korneva V. B. Nikolaev K. Yu. Yastremskaya E. Yu. Markov V. V. Voytkova S. Yu. Solovyov Yu. O. Popova A. V. Mazepa T. A. Ivanova V. S. Polovinkina |
| author_facet | A. V. Korneva V. B. Nikolaev K. Yu. Yastremskaya E. Yu. Markov V. V. Voytkova S. Yu. Solovyov Yu. O. Popova A. V. Mazepa T. A. Ivanova V. S. Polovinkina |
| author_sort | A. V. Korneva |
| collection | DOAJ |
| description | The effect of cell envelopes preparations of four subspecies of Francisella tularensis, derived from urea lysates of tularemia microbe on cytokine production by immunocompetent cells of experimental animals has been studied. Stimulating influence of F. tularensis cell envelopes preparations on cytokine synthesis on the 7th day after inoculation was shown. The results showed that the cell envelopes of different subspecies F. tularensis have different stimulatory effect on the production of proinflammatory cytokines and growth factors GM-CSF and G-CSF, further defining the immune system of host.The results allow to consider cell envelopes preparations of F. tularensis as constituent component in the development of subunit vaccines. |
| first_indexed | 2024-03-08T12:19:58Z |
| format | Article |
| id | doaj.art-6a29c8b8dff24acaa41a129c3dacfa70 |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:20:28Z |
| publishDate | 2015-02-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-6a29c8b8dff24acaa41a129c3dacfa702024-03-28T07:49:13ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962015-02-0101636613Results of the study of the immunogenic activity of cell envelopes of Francisella tularensis different subspicies (Report 2)A. V. Korneva0V. B. Nikolaev1K. Yu. Yastremskaya2E. Yu. Markov3V. V. Voytkova4S. Yu. Solovyov5Yu. O. Popova6A. V. Mazepa7T. A. Ivanova8V. S. Polovinkina9Irkutsk Antiplague Research Institute of RospotrebnadzorIrkutsk Antiplague Research Institute of RospotrebnadzorIrkutsk Antiplague Research Institute of RospotrebnadzorIrkutsk Antiplague Research Institute of RospotrebnadzorIrkutsk Antiplague Research Institute of RospotrebnadzorIrkutsk Antiplague Research Institute of RospotrebnadzorIrkutsk Antiplague Research Institute of RospotrebnadzorIrkutsk Antiplague Research Institute of RospotrebnadzorIrkutsk Antiplague Research Institute of RospotrebnadzorIrkutsk Antiplague Research Institute of RospotrebnadzorThe effect of cell envelopes preparations of four subspecies of Francisella tularensis, derived from urea lysates of tularemia microbe on cytokine production by immunocompetent cells of experimental animals has been studied. Stimulating influence of F. tularensis cell envelopes preparations on cytokine synthesis on the 7th day after inoculation was shown. The results showed that the cell envelopes of different subspecies F. tularensis have different stimulatory effect on the production of proinflammatory cytokines and growth factors GM-CSF and G-CSF, further defining the immune system of host.The results allow to consider cell envelopes preparations of F. tularensis as constituent component in the development of subunit vaccines.https://www.actabiomedica.ru/jour/article/view/13tularemiafrancisella tularensiscell membranescytokinesimmune cellsvaccinesfrancisella tularensis |
| spellingShingle | A. V. Korneva V. B. Nikolaev K. Yu. Yastremskaya E. Yu. Markov V. V. Voytkova S. Yu. Solovyov Yu. O. Popova A. V. Mazepa T. A. Ivanova V. S. Polovinkina Results of the study of the immunogenic activity of cell envelopes of Francisella tularensis different subspicies (Report 2) Acta Biomedica Scientifica tularemia francisella tularensis cell membranes cytokines immune cells vaccines francisella tularensis |
| title | Results of the study of the immunogenic activity of cell envelopes of Francisella tularensis different subspicies (Report 2) |
| title_full | Results of the study of the immunogenic activity of cell envelopes of Francisella tularensis different subspicies (Report 2) |
| title_fullStr | Results of the study of the immunogenic activity of cell envelopes of Francisella tularensis different subspicies (Report 2) |
| title_full_unstemmed | Results of the study of the immunogenic activity of cell envelopes of Francisella tularensis different subspicies (Report 2) |
| title_short | Results of the study of the immunogenic activity of cell envelopes of Francisella tularensis different subspicies (Report 2) |
| title_sort | results of the study of the immunogenic activity of cell envelopes of francisella tularensis different subspicies report 2 |
| topic | tularemia francisella tularensis cell membranes cytokines immune cells vaccines francisella tularensis |
| url | https://www.actabiomedica.ru/jour/article/view/13 |
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