Does the Automatic Measurement of Interleukin 6 Allow for Prediction of Complications during the First 48 h of Acute Pancreatitis?
Acute pancreatitis (AP) in most patients takes a course of self-limiting local inflammation. However, up to 20% of patients develop severe AP (SAP), associated with systemic inflammation and/or pancreatic necrosis. Early prediction of SAP allows for the appropriate intensive treatment of severe case...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-06-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1422-0067/19/6/1820 |
| _version_ | 1811193481696116736 |
|---|---|
| author | Witold Kolber Paulina Dumnicka Małgorzata Maraj Beata Kuśnierz-Cabala Piotr Ceranowicz Michał Pędziwiatr Barbara Maziarz Małgorzata Mazur-Laskowska Marek Kuźniewski Mateusz Sporek Jerzy Walocha |
| author_facet | Witold Kolber Paulina Dumnicka Małgorzata Maraj Beata Kuśnierz-Cabala Piotr Ceranowicz Michał Pędziwiatr Barbara Maziarz Małgorzata Mazur-Laskowska Marek Kuźniewski Mateusz Sporek Jerzy Walocha |
| author_sort | Witold Kolber |
| collection | DOAJ |
| description | Acute pancreatitis (AP) in most patients takes a course of self-limiting local inflammation. However, up to 20% of patients develop severe AP (SAP), associated with systemic inflammation and/or pancreatic necrosis. Early prediction of SAP allows for the appropriate intensive treatment of severe cases, which reduces mortality. Serum interleukin-6 (IL-6) has been proposed as a biomarker to assist early diagnosis of SAP, however, most data come from studies utilizing IL-6 measurements with ELISA. Our aim was to verify the diagnostic usefulness of IL-6 for the prediction of SAP, organ failure, and need for intensive care in the course of AP using a fully automated assay. The study included 95 adult patients with AP of various severity (29 mild, 58 moderately-severe, 8 severe) admitted to a hospital within 24 h from the onset of symptoms. Serum IL-6 was measured using electochemiluminescence immunoassay in samples collected on admission and on the next day of hospital stay. On both days, patients with SAP presented the highest IL-6 levels. IL-6 correlated positively with other inflammatory markers (white blood cell and neutrophil counts, C-reactive protein, procalcitonin), the markers of renal injury (kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin), and the markers of endothelial dysfunction (angiopoietin-2, soluble fms-like tyrosine kinase-1). IL-6 on admission significantly predicted SAP, vital organ failure, and the need for intensive care or death, with areas under the receiver operating curve between 0.75 and 0.78, not significantly different from multi-variable prognostic scores. The fully automated assay allows for fast and repeatable measurements of serum IL-6, enabling wider clinical use of this valuable biomarker. |
| first_indexed | 2024-04-12T00:09:32Z |
| format | Article |
| id | doaj.art-6a2a660ed0364b768822ad870ff65bbc |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T00:09:32Z |
| publishDate | 2018-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6a2a660ed0364b768822ad870ff65bbc2022-12-22T03:56:00ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-06-01196182010.3390/ijms19061820ijms19061820Does the Automatic Measurement of Interleukin 6 Allow for Prediction of Complications during the First 48 h of Acute Pancreatitis?Witold Kolber0Paulina Dumnicka1Małgorzata Maraj2Beata Kuśnierz-Cabala3Piotr Ceranowicz4Michał Pędziwiatr5Barbara Maziarz6Małgorzata Mazur-Laskowska7Marek Kuźniewski8Mateusz Sporek9Jerzy Walocha10Department of Surgery, Complex of Health Care Centers in Wadowice, Karmelicka 5 St., 34-100 Wadowice, PolandDepartment of Medical Diagnostics, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 St., 30-688 Krakow, PolandDepartment of Physiology, Jagiellonian University Medical College, Grzegorzecka 16 St., 31-531 Krakow, PolandDepartment of Diagnostics, Chair of Clinical Biochemistry, Jagiellonian University Medical College, Kopernika 15A St., 31-501 Krakow, PolandDepartment of Physiology, Jagiellonian University Medical College, Grzegorzecka 16 St., 31-531 Krakow, Poland2nd Department of Surgery, Jagiellonian University Medical College, Kopernika 21 St., 31-501 Krakow, PolandDepartment of Diagnostics, Chair of Clinical Biochemistry, Jagiellonian University Medical College, Kopernika 15A St., 31-501 Krakow, PolandDiagnostics Department of University Hospital in Krakow, Kopernika 15B St., 31-501 Krakow, PolandDepartment of Nephrology, Jagiellonian University Medical College, Kopernika 15 St., 31-501 Krakow, PolandDepartment of Anatomy, Jagiellonian University Medical College, Kopernika 12 St., 31-034 Krakow, PolandDepartment of Anatomy, Jagiellonian University Medical College, Kopernika 12 St., 31-034 Krakow, PolandAcute pancreatitis (AP) in most patients takes a course of self-limiting local inflammation. However, up to 20% of patients develop severe AP (SAP), associated with systemic inflammation and/or pancreatic necrosis. Early prediction of SAP allows for the appropriate intensive treatment of severe cases, which reduces mortality. Serum interleukin-6 (IL-6) has been proposed as a biomarker to assist early diagnosis of SAP, however, most data come from studies utilizing IL-6 measurements with ELISA. Our aim was to verify the diagnostic usefulness of IL-6 for the prediction of SAP, organ failure, and need for intensive care in the course of AP using a fully automated assay. The study included 95 adult patients with AP of various severity (29 mild, 58 moderately-severe, 8 severe) admitted to a hospital within 24 h from the onset of symptoms. Serum IL-6 was measured using electochemiluminescence immunoassay in samples collected on admission and on the next day of hospital stay. On both days, patients with SAP presented the highest IL-6 levels. IL-6 correlated positively with other inflammatory markers (white blood cell and neutrophil counts, C-reactive protein, procalcitonin), the markers of renal injury (kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin), and the markers of endothelial dysfunction (angiopoietin-2, soluble fms-like tyrosine kinase-1). IL-6 on admission significantly predicted SAP, vital organ failure, and the need for intensive care or death, with areas under the receiver operating curve between 0.75 and 0.78, not significantly different from multi-variable prognostic scores. The fully automated assay allows for fast and repeatable measurements of serum IL-6, enabling wider clinical use of this valuable biomarker.http://www.mdpi.com/1422-0067/19/6/1820interleukin 6acute pancreatitisseverityprediction of acute pancreatitisorgan failure |
| spellingShingle | Witold Kolber Paulina Dumnicka Małgorzata Maraj Beata Kuśnierz-Cabala Piotr Ceranowicz Michał Pędziwiatr Barbara Maziarz Małgorzata Mazur-Laskowska Marek Kuźniewski Mateusz Sporek Jerzy Walocha Does the Automatic Measurement of Interleukin 6 Allow for Prediction of Complications during the First 48 h of Acute Pancreatitis? International Journal of Molecular Sciences interleukin 6 acute pancreatitis severity prediction of acute pancreatitis organ failure |
| title | Does the Automatic Measurement of Interleukin 6 Allow for Prediction of Complications during the First 48 h of Acute Pancreatitis? |
| title_full | Does the Automatic Measurement of Interleukin 6 Allow for Prediction of Complications during the First 48 h of Acute Pancreatitis? |
| title_fullStr | Does the Automatic Measurement of Interleukin 6 Allow for Prediction of Complications during the First 48 h of Acute Pancreatitis? |
| title_full_unstemmed | Does the Automatic Measurement of Interleukin 6 Allow for Prediction of Complications during the First 48 h of Acute Pancreatitis? |
| title_short | Does the Automatic Measurement of Interleukin 6 Allow for Prediction of Complications during the First 48 h of Acute Pancreatitis? |
| title_sort | does the automatic measurement of interleukin 6 allow for prediction of complications during the first 48 h of acute pancreatitis |
| topic | interleukin 6 acute pancreatitis severity prediction of acute pancreatitis organ failure |
| url | http://www.mdpi.com/1422-0067/19/6/1820 |
| work_keys_str_mv | AT witoldkolber doestheautomaticmeasurementofinterleukin6allowforpredictionofcomplicationsduringthefirst48hofacutepancreatitis AT paulinadumnicka doestheautomaticmeasurementofinterleukin6allowforpredictionofcomplicationsduringthefirst48hofacutepancreatitis AT małgorzatamaraj doestheautomaticmeasurementofinterleukin6allowforpredictionofcomplicationsduringthefirst48hofacutepancreatitis AT beatakusnierzcabala doestheautomaticmeasurementofinterleukin6allowforpredictionofcomplicationsduringthefirst48hofacutepancreatitis AT piotrceranowicz doestheautomaticmeasurementofinterleukin6allowforpredictionofcomplicationsduringthefirst48hofacutepancreatitis AT michałpedziwiatr doestheautomaticmeasurementofinterleukin6allowforpredictionofcomplicationsduringthefirst48hofacutepancreatitis AT barbaramaziarz doestheautomaticmeasurementofinterleukin6allowforpredictionofcomplicationsduringthefirst48hofacutepancreatitis AT małgorzatamazurlaskowska doestheautomaticmeasurementofinterleukin6allowforpredictionofcomplicationsduringthefirst48hofacutepancreatitis AT marekkuzniewski doestheautomaticmeasurementofinterleukin6allowforpredictionofcomplicationsduringthefirst48hofacutepancreatitis AT mateuszsporek doestheautomaticmeasurementofinterleukin6allowforpredictionofcomplicationsduringthefirst48hofacutepancreatitis AT jerzywalocha doestheautomaticmeasurementofinterleukin6allowforpredictionofcomplicationsduringthefirst48hofacutepancreatitis |