The Association of Thrombosis-Related Factors Polymorphisms and the Risk of Uterine Myoma
Background: Myomas are benign monoclonal tumors of the smooth muscle cells of the endometrium. Venous thromboembolism (VTE) is a common complication of cancers; however, their contributions to thrombotic tendency in patients with cancer have conflicting results. The present study was designed to inv...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2014-11-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/3979 |
| _version_ | 1827842657331707904 |
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| author | Mohadeseh Arabnejad Ahmad Ebrahimi Mahboobeh Nasiri Mehran Karimi |
| author_facet | Mohadeseh Arabnejad Ahmad Ebrahimi Mahboobeh Nasiri Mehran Karimi |
| author_sort | Mohadeseh Arabnejad |
| collection | DOAJ |
| description | Background: Myomas are benign monoclonal tumors of the smooth muscle cells of the endometrium. Venous thromboembolism (VTE) is a common complication of cancers; however, their contributions to thrombotic tendency in patients with cancer have conflicting results. The present study was designed to investigate the relationship of the polymorphisms of clotting factor gene and the risk of uterine myoma.
Methods: In this study, three selected polymorphisms of thrombotic factors gene were evaluated using amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) method. We focused on the prevalence of PTH G20210A, FGB G-455A and PAI-1 4G/5G polymorphisms in 50 women with clinically diagnosed uterine myoma and 50 healthy controls. The data were analyzed using chi-square test via SPSS19 software.
Findings: The PTH (rs1799963), FGB (rs1800790) and PAI-1 (rs1799889) polymorphisms were not correlated with an increased risk of uterine myoma in the study population (P > 0.05).
Conclusion: We observed no associations of the investigated polymorphisms with the risk of uterine myoma in studied population. |
| first_indexed | 2024-03-12T08:13:51Z |
| format | Article |
| id | doaj.art-6a2a6aa75ddb4003b04e8276fcdfd1d5 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T08:13:51Z |
| publishDate | 2014-11-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-6a2a6aa75ddb4003b04e8276fcdfd1d52023-09-02T19:01:18ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2014-11-0132303159416041705The Association of Thrombosis-Related Factors Polymorphisms and the Risk of Uterine MyomaMohadeseh Arabnejad0Ahmad Ebrahimi1Mahboobeh Nasiri2Mehran Karimi3Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, IranAssistant Professor, Cellular and Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranAssistant Professor, Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, IranAssociate Professor, Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, IranBackground: Myomas are benign monoclonal tumors of the smooth muscle cells of the endometrium. Venous thromboembolism (VTE) is a common complication of cancers; however, their contributions to thrombotic tendency in patients with cancer have conflicting results. The present study was designed to investigate the relationship of the polymorphisms of clotting factor gene and the risk of uterine myoma. Methods: In this study, three selected polymorphisms of thrombotic factors gene were evaluated using amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) method. We focused on the prevalence of PTH G20210A, FGB G-455A and PAI-1 4G/5G polymorphisms in 50 women with clinically diagnosed uterine myoma and 50 healthy controls. The data were analyzed using chi-square test via SPSS19 software. Findings: The PTH (rs1799963), FGB (rs1800790) and PAI-1 (rs1799889) polymorphisms were not correlated with an increased risk of uterine myoma in the study population (P > 0.05). Conclusion: We observed no associations of the investigated polymorphisms with the risk of uterine myoma in studied population.http://jims.mui.ac.ir/index.php/jims/article/view/3979Thrombosis factorUterine myomaPTH G20210AFGB G-455APAI-14G/5G |
| spellingShingle | Mohadeseh Arabnejad Ahmad Ebrahimi Mahboobeh Nasiri Mehran Karimi The Association of Thrombosis-Related Factors Polymorphisms and the Risk of Uterine Myoma مجله دانشکده پزشکی اصفهان Thrombosis factor Uterine myoma PTH G20210A FGB G-455A PAI-14G/5G |
| title | The Association of Thrombosis-Related Factors Polymorphisms and the Risk of Uterine Myoma |
| title_full | The Association of Thrombosis-Related Factors Polymorphisms and the Risk of Uterine Myoma |
| title_fullStr | The Association of Thrombosis-Related Factors Polymorphisms and the Risk of Uterine Myoma |
| title_full_unstemmed | The Association of Thrombosis-Related Factors Polymorphisms and the Risk of Uterine Myoma |
| title_short | The Association of Thrombosis-Related Factors Polymorphisms and the Risk of Uterine Myoma |
| title_sort | association of thrombosis related factors polymorphisms and the risk of uterine myoma |
| topic | Thrombosis factor Uterine myoma PTH G20210A FGB G-455A PAI-14G/5G |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/3979 |
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