Quantum Dot Imaging Agents: Haematopoietic Cell Interactions and Biocompatibility
Quantum dots (QDs) are semi-conducting nanoparticles that have been developed for a range of biological and non-biological functions. They can be tuned to multiple different emission wavelengths and can have significant benefits over other fluorescent systems. Many studies have utilised QDs with a c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/13/4/354 |
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| author | Leigh Naylor-Adamson Thomas W. Price Zoe Booth Graeme J. Stasiuk Simon D. J. Calaminus |
| author_facet | Leigh Naylor-Adamson Thomas W. Price Zoe Booth Graeme J. Stasiuk Simon D. J. Calaminus |
| author_sort | Leigh Naylor-Adamson |
| collection | DOAJ |
| description | Quantum dots (QDs) are semi-conducting nanoparticles that have been developed for a range of biological and non-biological functions. They can be tuned to multiple different emission wavelengths and can have significant benefits over other fluorescent systems. Many studies have utilised QDs with a cadmium-based core; however, these QDs have since been shown to have poor biological compatibility. Therefore, other QDs, such as indium phosphide QDs, have been developed. These QDs retain excellent fluorescent intensity and tunability but are thought to have elevated biological compatibility. Herein we discuss the applicability of a range of QDs to the cardiovascular system. Key disease states such as myocardial infarction and stroke are associated with cardiovascular disease (CVD), and there is an opportunity to improve clinical imaging to aide clinical outcomes for these disease states. QDs offer potential clinical benefits given their ability to perform multiple functions, such as carry an imaging agent, a therapy, and a targeting motif. Two key cell types associated with CVD are platelets and immune cells. Both cell types play key roles in establishing an inflammatory environment within CVD, and as such aid the formation of pathological thrombi. However, it is unclear at present how and with which cell types QDs interact, and if they potentially drive unwanted changes or activation of these cell types. Therefore, although QDs show great promise for boosting imaging capability, further work needs to be completed to fully understand their biological compatibility. |
| first_indexed | 2024-03-07T22:37:39Z |
| format | Article |
| id | doaj.art-6a2df1e74d284d4fa10e43774f0d5942 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-07T22:37:39Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-6a2df1e74d284d4fa10e43774f0d59422024-02-23T15:11:59ZengMDPI AGCells2073-44092024-02-0113435410.3390/cells13040354Quantum Dot Imaging Agents: Haematopoietic Cell Interactions and BiocompatibilityLeigh Naylor-Adamson0Thomas W. Price1Zoe Booth2Graeme J. Stasiuk3Simon D. J. Calaminus4Centre for Biomedicine, Hull York Medical School, University of Hull, Hull HU6 7RX, UKDepartment of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UKCentre for Biomedicine, Hull York Medical School, University of Hull, Hull HU6 7RX, UKDepartment of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King’s College London, London SE1 7EH, UKCentre for Biomedicine, Hull York Medical School, University of Hull, Hull HU6 7RX, UKQuantum dots (QDs) are semi-conducting nanoparticles that have been developed for a range of biological and non-biological functions. They can be tuned to multiple different emission wavelengths and can have significant benefits over other fluorescent systems. Many studies have utilised QDs with a cadmium-based core; however, these QDs have since been shown to have poor biological compatibility. Therefore, other QDs, such as indium phosphide QDs, have been developed. These QDs retain excellent fluorescent intensity and tunability but are thought to have elevated biological compatibility. Herein we discuss the applicability of a range of QDs to the cardiovascular system. Key disease states such as myocardial infarction and stroke are associated with cardiovascular disease (CVD), and there is an opportunity to improve clinical imaging to aide clinical outcomes for these disease states. QDs offer potential clinical benefits given their ability to perform multiple functions, such as carry an imaging agent, a therapy, and a targeting motif. Two key cell types associated with CVD are platelets and immune cells. Both cell types play key roles in establishing an inflammatory environment within CVD, and as such aid the formation of pathological thrombi. However, it is unclear at present how and with which cell types QDs interact, and if they potentially drive unwanted changes or activation of these cell types. Therefore, although QDs show great promise for boosting imaging capability, further work needs to be completed to fully understand their biological compatibility.https://www.mdpi.com/2073-4409/13/4/354quantum dotscardiovascular diseasesimaging |
| spellingShingle | Leigh Naylor-Adamson Thomas W. Price Zoe Booth Graeme J. Stasiuk Simon D. J. Calaminus Quantum Dot Imaging Agents: Haematopoietic Cell Interactions and Biocompatibility Cells quantum dots cardiovascular diseases imaging |
| title | Quantum Dot Imaging Agents: Haematopoietic Cell Interactions and Biocompatibility |
| title_full | Quantum Dot Imaging Agents: Haematopoietic Cell Interactions and Biocompatibility |
| title_fullStr | Quantum Dot Imaging Agents: Haematopoietic Cell Interactions and Biocompatibility |
| title_full_unstemmed | Quantum Dot Imaging Agents: Haematopoietic Cell Interactions and Biocompatibility |
| title_short | Quantum Dot Imaging Agents: Haematopoietic Cell Interactions and Biocompatibility |
| title_sort | quantum dot imaging agents haematopoietic cell interactions and biocompatibility |
| topic | quantum dots cardiovascular diseases imaging |
| url | https://www.mdpi.com/2073-4409/13/4/354 |
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