The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications
The recent discovery of human-induced pluripotent stem cells (iPSC) has revolutionized the field of stem cells. iPSC have demonstrated that biological development is not an irreversible process and that mature adult somatic cells can be induced to become pluripotent. This breakthrough is projected t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-10-01
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| Series: | JACC: Basic to Translational Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452302X16301103 |
| _version_ | 1818484882903400448 |
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| author | Amr A. Youssef, MD, PhD Elsie Gyang Ross, MD, MSc Roberto Bolli, MD Carl J. Pepine, MD Nicholas J. Leeper, MD Phillip C. Yang, MD |
| author_facet | Amr A. Youssef, MD, PhD Elsie Gyang Ross, MD, MSc Roberto Bolli, MD Carl J. Pepine, MD Nicholas J. Leeper, MD Phillip C. Yang, MD |
| author_sort | Amr A. Youssef, MD, PhD |
| collection | DOAJ |
| description | The recent discovery of human-induced pluripotent stem cells (iPSC) has revolutionized the field of stem cells. iPSC have demonstrated that biological development is not an irreversible process and that mature adult somatic cells can be induced to become pluripotent. This breakthrough is projected to advance our current understanding of many disease processes and revolutionize the approach to effective therapeutics. Despite the great promise of iPSC, many translational challenges still remain. The authors review the basic concept of induction of pluripotency as a novel approach to understand cardiac regeneration, cardiovascular disease modeling, and drug discovery. They critically reflect on the current results of pre-clinical and clinical studies using iPSC for these applications with appropriate emphasis on the challenges facing clinical translation. |
| first_indexed | 2024-12-10T16:00:42Z |
| format | Article |
| id | doaj.art-6a30502f90f54888ba32cf78ea3a0abc |
| institution | Directory Open Access Journal |
| issn | 2452-302X |
| language | English |
| last_indexed | 2024-12-10T16:00:42Z |
| publishDate | 2016-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JACC: Basic to Translational Science |
| spelling | doaj.art-6a30502f90f54888ba32cf78ea3a0abc2022-12-22T01:42:26ZengElsevierJACC: Basic to Translational Science2452-302X2016-10-011651052310.1016/j.jacbts.2016.06.010The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular ApplicationsAmr A. Youssef, MD, PhD0Elsie Gyang Ross, MD, MSc1Roberto Bolli, MD2Carl J. Pepine, MD3Nicholas J. Leeper, MD4Phillip C. Yang, MD5Division of Cardiology, Ain Shams University, Cairo, EgyptDivision of Cardiovascular Medicine, Stanford University, Stanford, CaliforniaDivision of Cardiovascular Medicine, University of Louisville, Louisville, KentuckyDivision of Cardiovascular Medicine, University of Florida, Gainesville, FloridaDivision of Cardiovascular Medicine, Stanford University, Stanford, CaliforniaDivision of Cardiovascular Medicine, Stanford University, Stanford, CaliforniaThe recent discovery of human-induced pluripotent stem cells (iPSC) has revolutionized the field of stem cells. iPSC have demonstrated that biological development is not an irreversible process and that mature adult somatic cells can be induced to become pluripotent. This breakthrough is projected to advance our current understanding of many disease processes and revolutionize the approach to effective therapeutics. Despite the great promise of iPSC, many translational challenges still remain. The authors review the basic concept of induction of pluripotency as a novel approach to understand cardiac regeneration, cardiovascular disease modeling, and drug discovery. They critically reflect on the current results of pre-clinical and clinical studies using iPSC for these applications with appropriate emphasis on the challenges facing clinical translation.http://www.sciencedirect.com/science/article/pii/S2452302X16301103cardiac regenerationdisease modelingdrug discoveryinduced pluripotent stem cells |
| spellingShingle | Amr A. Youssef, MD, PhD Elsie Gyang Ross, MD, MSc Roberto Bolli, MD Carl J. Pepine, MD Nicholas J. Leeper, MD Phillip C. Yang, MD The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications JACC: Basic to Translational Science cardiac regeneration disease modeling drug discovery induced pluripotent stem cells |
| title | The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications |
| title_full | The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications |
| title_fullStr | The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications |
| title_full_unstemmed | The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications |
| title_short | The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications |
| title_sort | promise and challenge of induced pluripotent stem cells for cardiovascular applications |
| topic | cardiac regeneration disease modeling drug discovery induced pluripotent stem cells |
| url | http://www.sciencedirect.com/science/article/pii/S2452302X16301103 |
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