栾树籽油对非酒精性脂肪肝的保护作用Protection effect of Koelreuteria paniculata seed oil on non- alcoholic fatty liver disease

栾树籽油对非酒精性脂肪肝的保护作用Protection effect of Koelreuteria paniculata seed oil on non- alcoholic fatty liver disease

为了促进栾树资源的开发和利用，通过体外细胞实验和体内动物实验研究了栾树籽油对非酒精性脂肪肝（NAFLD）的保护作用。体外实验采用游离脂肪酸（FFA）诱导人正常肝细胞系Lo-2，建立NAFLD细胞模型，观察栾树籽油的干预对Lo-2细胞脂肪变性以及甘油三酯（TG）含量的影响，观察栾树籽油对NAFLD细胞脂质堆积的影响。体内实验采用高脂饲料饲养诱导建立NAFLD小鼠模型，造模成功后连续灌胃给药7 d，取小鼠血清、肝脏组织，观察肝脏组织病理学，检测血清及肝脏组织总胆固醇（TC）、TG、谷草转氨酶（AST）和谷丙转氨酶（ALT）水平，探讨栾树籽油对NAFLD小鼠肝脏的保护作用。结果显示：通过FFA诱导L...

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Bibliographic Details
Main Author:	郑蕾1，2，李欣禹1，杨文涛1，张存劳1，郭建博2，3，徐玥1，2 ZHENG Lei1，2，LI Xinyu1，YANG Wentao1， ZHANG Cunlao1， GUO Jianbo2，3，XU Yue1，2
Format:	Article
Language:	English
Published:	中粮工科（西安）国际工程有限公司 2023-08-01
Series:	Zhongguo youzhi
Subjects:	栾树籽油；非酒精性脂肪肝；lo-2；降脂护肝 koelreuteria paniculata seed oil; nafld; lo-2; lowering lipid and protecting liver
Online Access:	http://tg.chinaoils.cn/ch/reader/create_pdf.aspx?file_no=20230813&flag=1

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