Age-Associated Differences in Recovery from Exercise-Induced Muscle Damage
Understanding the intricate mechanisms governing the cellular response to resistance exercise is paramount for promoting healthy aging. This narrative review explored the age-related alterations in recovery from resistance exercise, focusing on the nuanced aspects of exercise-induced muscle damage i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/13/3/255 |
| _version_ | 1797318933678653440 |
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| author | Donna Ching Wah Li Stefan Rudloff Henning Tim Langer Kristina Norman Catrin Herpich |
| author_facet | Donna Ching Wah Li Stefan Rudloff Henning Tim Langer Kristina Norman Catrin Herpich |
| author_sort | Donna Ching Wah Li |
| collection | DOAJ |
| description | Understanding the intricate mechanisms governing the cellular response to resistance exercise is paramount for promoting healthy aging. This narrative review explored the age-related alterations in recovery from resistance exercise, focusing on the nuanced aspects of exercise-induced muscle damage in older adults. Due to the limited number of studies in older adults that attempt to delineate age differences in muscle discovery, we delve into the multifaceted cellular influences of chronic low-grade inflammation, modifications in the extracellular matrix, and the role of lipid mediators in shaping the recovery landscape in aging skeletal muscle. From our literature search, it is evident that aged muscle displays delayed, prolonged, and inefficient recovery. These changes can be attributed to anabolic resistance, the stiffening of the extracellular matrix, mitochondrial dysfunction, and unresolved inflammation as well as alterations in satellite cell function. Collectively, these age-related impairments may impact subsequent adaptations to resistance exercise. Insights gleaned from this exploration may inform targeted interventions aimed at enhancing the efficacy of resistance training programs tailored to the specific needs of older adults, ultimately fostering healthy aging and preserving functional independence. |
| first_indexed | 2024-03-08T03:59:35Z |
| format | Article |
| id | doaj.art-6a30f01b86f6451ca4efb80b58a1cb33 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-08T03:59:35Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-6a30f01b86f6451ca4efb80b58a1cb332024-02-09T15:09:45ZengMDPI AGCells2073-44092024-01-0113325510.3390/cells13030255Age-Associated Differences in Recovery from Exercise-Induced Muscle DamageDonna Ching Wah Li0Stefan Rudloff1Henning Tim Langer2Kristina Norman3Catrin Herpich4Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbrücke, 14558 Nuthetal, GermanyDepartment of Geriatrics and Medical Gerontology, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 13347 Berlin, GermanyDepartment of Medicine, Weill Cornell Medicine, New York, NY 10065, USADepartment of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbrücke, 14558 Nuthetal, GermanyDepartment of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbrücke, 14558 Nuthetal, GermanyUnderstanding the intricate mechanisms governing the cellular response to resistance exercise is paramount for promoting healthy aging. This narrative review explored the age-related alterations in recovery from resistance exercise, focusing on the nuanced aspects of exercise-induced muscle damage in older adults. Due to the limited number of studies in older adults that attempt to delineate age differences in muscle discovery, we delve into the multifaceted cellular influences of chronic low-grade inflammation, modifications in the extracellular matrix, and the role of lipid mediators in shaping the recovery landscape in aging skeletal muscle. From our literature search, it is evident that aged muscle displays delayed, prolonged, and inefficient recovery. These changes can be attributed to anabolic resistance, the stiffening of the extracellular matrix, mitochondrial dysfunction, and unresolved inflammation as well as alterations in satellite cell function. Collectively, these age-related impairments may impact subsequent adaptations to resistance exercise. Insights gleaned from this exploration may inform targeted interventions aimed at enhancing the efficacy of resistance training programs tailored to the specific needs of older adults, ultimately fostering healthy aging and preserving functional independence.https://www.mdpi.com/2073-4409/13/3/255agingexerciserecoveryEIMD |
| spellingShingle | Donna Ching Wah Li Stefan Rudloff Henning Tim Langer Kristina Norman Catrin Herpich Age-Associated Differences in Recovery from Exercise-Induced Muscle Damage Cells aging exercise recovery EIMD |
| title | Age-Associated Differences in Recovery from Exercise-Induced Muscle Damage |
| title_full | Age-Associated Differences in Recovery from Exercise-Induced Muscle Damage |
| title_fullStr | Age-Associated Differences in Recovery from Exercise-Induced Muscle Damage |
| title_full_unstemmed | Age-Associated Differences in Recovery from Exercise-Induced Muscle Damage |
| title_short | Age-Associated Differences in Recovery from Exercise-Induced Muscle Damage |
| title_sort | age associated differences in recovery from exercise induced muscle damage |
| topic | aging exercise recovery EIMD |
| url | https://www.mdpi.com/2073-4409/13/3/255 |
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