Risk factors for left ventricular dysfunction in adulthood: role of low birth weight
Abstract Aims This study aimed to determine the relationship of low birth weight (LBW) with adult cardiac structure and function and investigate potential causal pathways. Methods and results A population‐based sample of 925 Australians (41.3% male) were followed from childhood (aged 7–15 years) to...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-12-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.13632 |
| _version_ | 1818205662758305792 |
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| author | Quan L. Huynh Alison J. Venn Costan G. Magnussen Hong Yang Terence Dwyer Thomas H. Marwick |
| author_facet | Quan L. Huynh Alison J. Venn Costan G. Magnussen Hong Yang Terence Dwyer Thomas H. Marwick |
| author_sort | Quan L. Huynh |
| collection | DOAJ |
| description | Abstract Aims This study aimed to determine the relationship of low birth weight (LBW) with adult cardiac structure and function and investigate potential causal pathways. Methods and results A population‐based sample of 925 Australians (41.3% male) were followed from childhood (aged 7–15 years) to young adulthood (aged 26–36 years) and mid‐adulthood (aged 36–50 years). Left ventricular (LV) global longitudinal strain (GLS, %), LV mass index (LVMi, g/m2.7), LV filling pressure (E/e′), and left atrial volume index (g/m2) were measured by transthoracic echocardiography in mid‐adulthood. Birth weight category was self‐reported in young adulthood and classified as low (≤5 lb or ≤2270 g), normal (5–8 lb or 2271–3630 g), and high (>8 lb or >3630 g). Of the 925 participants, 7.5% (n = 69) were classified as LBW. Compared with participants with normal birth weight, those with LBW had 2.01‐fold (95% confidence interval: 1.19, 3.41, P = 0.009) higher risks of impaired GLS (GLS > −18%) and 2.63‐fold (95% confidence interval: 0.89, 7.81, P = 0.08) higher risks of LV hypertrophy (LVMi > 48 g/m2.7 in men or >44 g/m2.7 in women) in adulthood, independent of age, sex, and any socio‐economic factors. Participants with LBW significantly increased body fat from childhood to adulthood relative to their peers and had greater levels of triglycerides, fasting glucose, and arterial stiffness in adulthood. These risk factors were the strongest mediators and explained 54% of the LBW effect size on adult GLS and 33% of the LBW effect size on LVMi. The remaining of these associations was independent of any of the measured risk factors. Conclusions Low birth weight was associated with impaired cardiac structure and function in mid‐adulthood. This association was only partially explained by known risk factors. |
| first_indexed | 2024-12-12T04:00:42Z |
| format | Article |
| id | doaj.art-6a316a4df29e4f1fa0ab02a940ffabc1 |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-12-12T04:00:42Z |
| publishDate | 2021-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-6a316a4df29e4f1fa0ab02a940ffabc12022-12-22T00:39:03ZengWileyESC Heart Failure2055-58222021-12-01865403541410.1002/ehf2.13632Risk factors for left ventricular dysfunction in adulthood: role of low birth weightQuan L. Huynh0Alison J. Venn1Costan G. Magnussen2Hong Yang3Terence Dwyer4Thomas H. Marwick5Baker Heart and Diabetes Institute 75 Commercial Road Melbourne Vic 3004 AustraliaMenzies Institute for Medical Research University of Tasmania Hobart AustraliaMenzies Institute for Medical Research University of Tasmania Hobart AustraliaMenzies Institute for Medical Research University of Tasmania Hobart AustraliaMenzies Institute for Medical Research University of Tasmania Hobart AustraliaBaker Heart and Diabetes Institute 75 Commercial Road Melbourne Vic 3004 AustraliaAbstract Aims This study aimed to determine the relationship of low birth weight (LBW) with adult cardiac structure and function and investigate potential causal pathways. Methods and results A population‐based sample of 925 Australians (41.3% male) were followed from childhood (aged 7–15 years) to young adulthood (aged 26–36 years) and mid‐adulthood (aged 36–50 years). Left ventricular (LV) global longitudinal strain (GLS, %), LV mass index (LVMi, g/m2.7), LV filling pressure (E/e′), and left atrial volume index (g/m2) were measured by transthoracic echocardiography in mid‐adulthood. Birth weight category was self‐reported in young adulthood and classified as low (≤5 lb or ≤2270 g), normal (5–8 lb or 2271–3630 g), and high (>8 lb or >3630 g). Of the 925 participants, 7.5% (n = 69) were classified as LBW. Compared with participants with normal birth weight, those with LBW had 2.01‐fold (95% confidence interval: 1.19, 3.41, P = 0.009) higher risks of impaired GLS (GLS > −18%) and 2.63‐fold (95% confidence interval: 0.89, 7.81, P = 0.08) higher risks of LV hypertrophy (LVMi > 48 g/m2.7 in men or >44 g/m2.7 in women) in adulthood, independent of age, sex, and any socio‐economic factors. Participants with LBW significantly increased body fat from childhood to adulthood relative to their peers and had greater levels of triglycerides, fasting glucose, and arterial stiffness in adulthood. These risk factors were the strongest mediators and explained 54% of the LBW effect size on adult GLS and 33% of the LBW effect size on LVMi. The remaining of these associations was independent of any of the measured risk factors. Conclusions Low birth weight was associated with impaired cardiac structure and function in mid‐adulthood. This association was only partially explained by known risk factors.https://doi.org/10.1002/ehf2.13632Low birth weightLeft ventricleGlobal longitudinal strainLV hypertrophy |
| spellingShingle | Quan L. Huynh Alison J. Venn Costan G. Magnussen Hong Yang Terence Dwyer Thomas H. Marwick Risk factors for left ventricular dysfunction in adulthood: role of low birth weight ESC Heart Failure Low birth weight Left ventricle Global longitudinal strain LV hypertrophy |
| title | Risk factors for left ventricular dysfunction in adulthood: role of low birth weight |
| title_full | Risk factors for left ventricular dysfunction in adulthood: role of low birth weight |
| title_fullStr | Risk factors for left ventricular dysfunction in adulthood: role of low birth weight |
| title_full_unstemmed | Risk factors for left ventricular dysfunction in adulthood: role of low birth weight |
| title_short | Risk factors for left ventricular dysfunction in adulthood: role of low birth weight |
| title_sort | risk factors for left ventricular dysfunction in adulthood role of low birth weight |
| topic | Low birth weight Left ventricle Global longitudinal strain LV hypertrophy |
| url | https://doi.org/10.1002/ehf2.13632 |
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