Prognostic Analysis of HPV Status in Sinonasal Squamous Cell Carcinoma
Sinonasal squamous cell carcinoma (SNSCC) is a rare and aggressive malignancy with poor prognosis. Human papilloma virus (HPV) can induce SNSCC although its incidence and impact on patients’ outcomes remains unclear. We performed a retrospective cohort study of patients with SNSCC treated consecutiv...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/8/1874 |
| _version_ | 1797436545688403968 |
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| author | Alexandre Tendron Marion Classe Odile Casiraghi Hélène Pere Caroline Even Philippe Gorphe Antoine Moya-Plana |
| author_facet | Alexandre Tendron Marion Classe Odile Casiraghi Hélène Pere Caroline Even Philippe Gorphe Antoine Moya-Plana |
| author_sort | Alexandre Tendron |
| collection | DOAJ |
| description | Sinonasal squamous cell carcinoma (SNSCC) is a rare and aggressive malignancy with poor prognosis. Human papilloma virus (HPV) can induce SNSCC although its incidence and impact on patients’ outcomes remains unclear. We performed a retrospective cohort study of patients with SNSCC treated consecutively in a comprehensive cancer center. HPV status was determined with p16 immunohistochemistry followed by RNA in situ hybridization (RNAscope). The incidence, clinical characteristics, and oncologic outcomes of HPV+SNSCC were assessed. P16 prognostic value was evaluated. Fifty-nine patients were included. Eleven (18.6%) SNSCC were p16+ with five (8.4%) doubtful cases. RNAscope was positive in nine cases (15.2%). Patients with HPV+SNSCC were younger (<i>p</i> = 0.0298) with a primary tumor originating mainly in nasal fossa (<i>p</i> < 10<sup>−4</sup>). Pathologic findings were not different according to HPV status. Among patients who were curatively treated, overall survival was better for HPV+SNSCC (<i>p</i> = 0.022). No prognostic value of p16 expression was reported. Patients with HPV+SNSCC have better oncologic outcomes, probably due to earlier tumor stage with primary location predominantly in the nasal fossa, a more suitable epicenter to perform a surgical resection with clear margins. P16 expression seems not to be a good surrogate of HPV status in SNSCC. |
| first_indexed | 2024-03-09T11:04:13Z |
| format | Article |
| id | doaj.art-6a31ca1f79d7414e81e514e0d9074c3c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T11:04:13Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-6a31ca1f79d7414e81e514e0d9074c3c2023-12-01T01:04:30ZengMDPI AGCancers2072-66942022-04-01148187410.3390/cancers14081874Prognostic Analysis of HPV Status in Sinonasal Squamous Cell CarcinomaAlexandre Tendron0Marion Classe1Odile Casiraghi2Hélène Pere3Caroline Even4Philippe Gorphe5Antoine Moya-Plana6Head and Neck Oncology Department, Gustave Roussy Cancer Campus, Université Paris Saclay, 94805 Villejuif, FranceMolecular Radiotherapy and Therapeutic Innovation, UMR 1030, 94805 Villejuif, FrancePathology Department, Gustave Roussy Cancer Campus, Université Paris Saclay, 94805 Villejuif, FranceVirology Department, European Hospital Georges Pompidou, 75015 Paris, FranceHead and Neck Oncology Department, Gustave Roussy Cancer Campus, Université Paris Saclay, 94805 Villejuif, FranceHead and Neck Oncology Department, Gustave Roussy Cancer Campus, Université Paris Saclay, 94805 Villejuif, FranceHead and Neck Oncology Department, Gustave Roussy Cancer Campus, Université Paris Saclay, 94805 Villejuif, FranceSinonasal squamous cell carcinoma (SNSCC) is a rare and aggressive malignancy with poor prognosis. Human papilloma virus (HPV) can induce SNSCC although its incidence and impact on patients’ outcomes remains unclear. We performed a retrospective cohort study of patients with SNSCC treated consecutively in a comprehensive cancer center. HPV status was determined with p16 immunohistochemistry followed by RNA in situ hybridization (RNAscope). The incidence, clinical characteristics, and oncologic outcomes of HPV+SNSCC were assessed. P16 prognostic value was evaluated. Fifty-nine patients were included. Eleven (18.6%) SNSCC were p16+ with five (8.4%) doubtful cases. RNAscope was positive in nine cases (15.2%). Patients with HPV+SNSCC were younger (<i>p</i> = 0.0298) with a primary tumor originating mainly in nasal fossa (<i>p</i> < 10<sup>−4</sup>). Pathologic findings were not different according to HPV status. Among patients who were curatively treated, overall survival was better for HPV+SNSCC (<i>p</i> = 0.022). No prognostic value of p16 expression was reported. Patients with HPV+SNSCC have better oncologic outcomes, probably due to earlier tumor stage with primary location predominantly in the nasal fossa, a more suitable epicenter to perform a surgical resection with clear margins. P16 expression seems not to be a good surrogate of HPV status in SNSCC.https://www.mdpi.com/2072-6694/14/8/1874HPVsinonasal cancersquamous cell carcinomanasal cavityoverall survivaldisease-free survival |
| spellingShingle | Alexandre Tendron Marion Classe Odile Casiraghi Hélène Pere Caroline Even Philippe Gorphe Antoine Moya-Plana Prognostic Analysis of HPV Status in Sinonasal Squamous Cell Carcinoma Cancers HPV sinonasal cancer squamous cell carcinoma nasal cavity overall survival disease-free survival |
| title | Prognostic Analysis of HPV Status in Sinonasal Squamous Cell Carcinoma |
| title_full | Prognostic Analysis of HPV Status in Sinonasal Squamous Cell Carcinoma |
| title_fullStr | Prognostic Analysis of HPV Status in Sinonasal Squamous Cell Carcinoma |
| title_full_unstemmed | Prognostic Analysis of HPV Status in Sinonasal Squamous Cell Carcinoma |
| title_short | Prognostic Analysis of HPV Status in Sinonasal Squamous Cell Carcinoma |
| title_sort | prognostic analysis of hpv status in sinonasal squamous cell carcinoma |
| topic | HPV sinonasal cancer squamous cell carcinoma nasal cavity overall survival disease-free survival |
| url | https://www.mdpi.com/2072-6694/14/8/1874 |
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