Does the Expression and Epigenetics of Genes Involved in Monogenic Forms of Parkinson’s Disease Influence Sporadic Forms?

Does the Expression and Epigenetics of Genes Involved in Monogenic Forms of Parkinson’s Disease Influence Sporadic Forms?

Parkinson’s disease (PD) is a disorder characterized by a triad of motor symptoms (akinesia, rigidity, resting tremor) related to loss of dopaminergic neurons mainly in the <i>Substantia nigra pars compacta</i>. Diagnosis is often made after a substantial loss of neurons has already occu...

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Bibliographic Details
Main Authors: Aymeric Lanore, Suzanne Lesage, Louise-Laure Mariani, Poornima Jayadev Menon, Philippe Ravassard, Helene Cheval, Olga Corti, Alexis Brice, Jean-Christophe Corvol
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Genes
Subjects:
Parkinson’s disease
Parkinson’s and related diseases
epigenetic
neurodegeneration
DNA methylation
histone modification
Online Access:https://www.mdpi.com/2073-4425/13/3/479

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