Synthesis and Evaluation of the Lifespan-Extension Properties of Oleracones D–F, Antioxidative Flavonoids from <i>Portulaca oleracea</i> L.
Plant-derived antioxidants have been widely used as supplementary health foods, as well as having been regarded as drug candidates for aging and aging-associated diseases. Oleracones, a novel series of flavonoids isolated from <i>Portulaca oleracea</i> L., possess potent antioxidative ac...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-09-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/9/19/4014 |
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| author | Jeong A Yoon Changjin Lim Dong Seok Cha Young Taek Han |
| author_facet | Jeong A Yoon Changjin Lim Dong Seok Cha Young Taek Han |
| author_sort | Jeong A Yoon |
| collection | DOAJ |
| description | Plant-derived antioxidants have been widely used as supplementary health foods, as well as having been regarded as drug candidates for aging and aging-associated diseases. Oleracones, a novel series of flavonoids isolated from <i>Portulaca oleracea</i> L., possess potent antioxidative activities and are expected to exhibit therapeutic potential on the aging process. The current paper describes the concise sequential synthesis of oleracones D−F. Oleracones D and F were efficiently synthesized via selective intramolecular oxa-Michael addition from oleracone E. In addition, we investigated their possible lifespan-extension properties using <i>Caenorhabditis elegans</i>, which is excellently suited as an experimental model to study aging. A significant longevity effect was observed when nematodes were grown with 20 <i>μ</i>M of oleracone E. |
| first_indexed | 2024-12-13T20:15:35Z |
| format | Article |
| id | doaj.art-6a330adfa92c4ec6b44331435d3330db |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-12-13T20:15:35Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-6a330adfa92c4ec6b44331435d3330db2022-12-21T23:32:49ZengMDPI AGApplied Sciences2076-34172019-09-01919401410.3390/app9194014app9194014Synthesis and Evaluation of the Lifespan-Extension Properties of Oleracones D–F, Antioxidative Flavonoids from <i>Portulaca oleracea</i> L.Jeong A Yoon0Changjin Lim1Dong Seok Cha2Young Taek Han3College of Pharmacy, Dankook University, Chenan 31116, KoreaCollege of Pharmacy, CHA University, Pocheon 11160, KoreaCollege of Pharmacy, Woosuk University, Jeonbuk 55338, KoreaCollege of Pharmacy, Dankook University, Chenan 31116, KoreaPlant-derived antioxidants have been widely used as supplementary health foods, as well as having been regarded as drug candidates for aging and aging-associated diseases. Oleracones, a novel series of flavonoids isolated from <i>Portulaca oleracea</i> L., possess potent antioxidative activities and are expected to exhibit therapeutic potential on the aging process. The current paper describes the concise sequential synthesis of oleracones D−F. Oleracones D and F were efficiently synthesized via selective intramolecular oxa-Michael addition from oleracone E. In addition, we investigated their possible lifespan-extension properties using <i>Caenorhabditis elegans</i>, which is excellently suited as an experimental model to study aging. A significant longevity effect was observed when nematodes were grown with 20 <i>μ</i>M of oleracone E.https://www.mdpi.com/2076-3417/9/19/4014oleraconeflavonoidanti-aginglongevity<i>portulaca oleracea</i> l.<i>caenorhabditis elegans</i>total synthesis |
| spellingShingle | Jeong A Yoon Changjin Lim Dong Seok Cha Young Taek Han Synthesis and Evaluation of the Lifespan-Extension Properties of Oleracones D–F, Antioxidative Flavonoids from <i>Portulaca oleracea</i> L. Applied Sciences oleracone flavonoid anti-aging longevity <i>portulaca oleracea</i> l. <i>caenorhabditis elegans</i> total synthesis |
| title | Synthesis and Evaluation of the Lifespan-Extension Properties of Oleracones D–F, Antioxidative Flavonoids from <i>Portulaca oleracea</i> L. |
| title_full | Synthesis and Evaluation of the Lifespan-Extension Properties of Oleracones D–F, Antioxidative Flavonoids from <i>Portulaca oleracea</i> L. |
| title_fullStr | Synthesis and Evaluation of the Lifespan-Extension Properties of Oleracones D–F, Antioxidative Flavonoids from <i>Portulaca oleracea</i> L. |
| title_full_unstemmed | Synthesis and Evaluation of the Lifespan-Extension Properties of Oleracones D–F, Antioxidative Flavonoids from <i>Portulaca oleracea</i> L. |
| title_short | Synthesis and Evaluation of the Lifespan-Extension Properties of Oleracones D–F, Antioxidative Flavonoids from <i>Portulaca oleracea</i> L. |
| title_sort | synthesis and evaluation of the lifespan extension properties of oleracones d f antioxidative flavonoids from i portulaca oleracea i l |
| topic | oleracone flavonoid anti-aging longevity <i>portulaca oleracea</i> l. <i>caenorhabditis elegans</i> total synthesis |
| url | https://www.mdpi.com/2076-3417/9/19/4014 |
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