Is microRNA-33 an Appropriate Target in the Treatment of Atherosclerosis?
The maintenance of cholesterol homeostasis is a complicated process involving regulation of cholesterol synthesis, dietary uptake and bile acid synthesis and excretion. Reverse cholesterol transport, described as the transfer of cholesterol from non-hepatic cells, including foam cells in atheroscler...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/4/902 |
| _version_ | 1797618887572848640 |
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| author | Malgorzata Sidorkiewicz |
| author_facet | Malgorzata Sidorkiewicz |
| author_sort | Malgorzata Sidorkiewicz |
| collection | DOAJ |
| description | The maintenance of cholesterol homeostasis is a complicated process involving regulation of cholesterol synthesis, dietary uptake and bile acid synthesis and excretion. Reverse cholesterol transport, described as the transfer of cholesterol from non-hepatic cells, including foam cells in atherosclerotic plaques, to the liver and then its excretion in the feces is important part of this regulation. High-density lipoproteins are the key mediators of reverse cholesterol transport. On the other hand, microRNA-33 was identified as a key regulator of cholesterol homeostasis. Recent studies indicate the impact of microRNA-33 not only on cellular cholesterol efflux and HDL production but also on bile metabolism in the liver. As proper coordination of cholesterol metabolism is essential to human health, discussion of recent findings in this field may open new perspectives in the microRNA-dependent treatment of a cholesterol imbalance. |
| first_indexed | 2024-03-11T08:19:55Z |
| format | Article |
| id | doaj.art-6a34fd4cb61044629a6b37b469e47cf2 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T08:19:55Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-6a34fd4cb61044629a6b37b469e47cf22023-11-16T22:30:32ZengMDPI AGNutrients2072-66432023-02-0115490210.3390/nu15040902Is microRNA-33 an Appropriate Target in the Treatment of Atherosclerosis?Malgorzata Sidorkiewicz0Department of Medical Biochemistry, Faculty of Health Sciences, Medical University of Lodz, 90-419 Lodz, PolandThe maintenance of cholesterol homeostasis is a complicated process involving regulation of cholesterol synthesis, dietary uptake and bile acid synthesis and excretion. Reverse cholesterol transport, described as the transfer of cholesterol from non-hepatic cells, including foam cells in atherosclerotic plaques, to the liver and then its excretion in the feces is important part of this regulation. High-density lipoproteins are the key mediators of reverse cholesterol transport. On the other hand, microRNA-33 was identified as a key regulator of cholesterol homeostasis. Recent studies indicate the impact of microRNA-33 not only on cellular cholesterol efflux and HDL production but also on bile metabolism in the liver. As proper coordination of cholesterol metabolism is essential to human health, discussion of recent findings in this field may open new perspectives in the microRNA-dependent treatment of a cholesterol imbalance.https://www.mdpi.com/2072-6643/15/4/902microRNA-33HDLatherosclerosischolesterol effluxreverse cholesterol transportbile acids |
| spellingShingle | Malgorzata Sidorkiewicz Is microRNA-33 an Appropriate Target in the Treatment of Atherosclerosis? Nutrients microRNA-33 HDL atherosclerosis cholesterol efflux reverse cholesterol transport bile acids |
| title | Is microRNA-33 an Appropriate Target in the Treatment of Atherosclerosis? |
| title_full | Is microRNA-33 an Appropriate Target in the Treatment of Atherosclerosis? |
| title_fullStr | Is microRNA-33 an Appropriate Target in the Treatment of Atherosclerosis? |
| title_full_unstemmed | Is microRNA-33 an Appropriate Target in the Treatment of Atherosclerosis? |
| title_short | Is microRNA-33 an Appropriate Target in the Treatment of Atherosclerosis? |
| title_sort | is microrna 33 an appropriate target in the treatment of atherosclerosis |
| topic | microRNA-33 HDL atherosclerosis cholesterol efflux reverse cholesterol transport bile acids |
| url | https://www.mdpi.com/2072-6643/15/4/902 |
| work_keys_str_mv | AT malgorzatasidorkiewicz ismicrorna33anappropriatetargetinthetreatmentofatherosclerosis |