IMMUNOPATHOGENESIS OF ACUTE RESPIRATORY INFECTIONS AND TACTICS OF RATIONAL CHOICE OF ETIOTROPIC IMMUNOMODULATORY THERAPIES IN CHILDREN
The article demonstrates that the basis for pathogenesis of acute respiratory infection (ARI ) is a deficiency in a number of factors of virus protection. This deficiency manifests itself through low concentration of interferon and secretory IgA in the nasal mucosa at higher levels of IL-8, alongsid...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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LLC "Diagnostics and Vaccines"
2015-08-01
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| Series: | Детские инфекции (Москва) |
| Subjects: | |
| Online Access: | https://detinf.elpub.ru/jour/article/view/148 |
| _version_ | 1797881840489463808 |
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| author | V. V. Malinovskaya V. P. Timina L. N. Mazankova T. A. Chebotareva |
| author_facet | V. V. Malinovskaya V. P. Timina L. N. Mazankova T. A. Chebotareva |
| author_sort | V. V. Malinovskaya |
| collection | DOAJ |
| description | The article demonstrates that the basis for pathogenesis of acute respiratory infection (ARI ) is a deficiency in a number of factors of virus protection. This deficiency manifests itself through low concentration of interferon and secretory IgA in the nasal mucosa at higher levels of IL-8, alongside with low serum antiviral activity and significant inhibition of interferon production and reduction of the compensatory mechanisms of adaptive immunity. These disorders require prescription of alpha-interferon preparations. For infants and children with a burdened pre-morbid background, regardless of age, such preparations can be administered with all clinical forms of ARI; in older children — with severe forms, including complications. Alpha-interferon preparations can be introduced at in any stage of the disease. Combination therapy with alpha-interferon drugs (VIFERON® suppositories and VIFERON® ointment) allows for enhanced clinical and immunological effects of therapy. |
| first_indexed | 2024-04-10T03:26:34Z |
| format | Article |
| id | doaj.art-6a3529d67eb84345a4aa589fb8ae9b70 |
| institution | Directory Open Access Journal |
| issn | 2072-8107 |
| language | Russian |
| last_indexed | 2024-04-10T03:26:34Z |
| publishDate | 2015-08-01 |
| publisher | LLC "Diagnostics and Vaccines" |
| record_format | Article |
| series | Детские инфекции (Москва) |
| spelling | doaj.art-6a3529d67eb84345a4aa589fb8ae9b702023-03-13T07:28:22ZrusLLC "Diagnostics and Vaccines"Детские инфекции (Москва)2072-81072015-08-01124141910.22627/2072-8107-2013-12-4-14-19148IMMUNOPATHOGENESIS OF ACUTE RESPIRATORY INFECTIONS AND TACTICS OF RATIONAL CHOICE OF ETIOTROPIC IMMUNOMODULATORY THERAPIES IN CHILDRENV. V. Malinovskaya0V. P. Timina1L. N. Mazankova2T. A. Chebotareva3НИИ эпидемиологии и микробиологии им. Н. Ф. Гамалеи, МоскваИнститут аллергологии и клинической иммунологии, МоскваРоссийская медицинская академия последипломного образования, МоскваРоссийская медицинская академия последипломного образования, МоскваThe article demonstrates that the basis for pathogenesis of acute respiratory infection (ARI ) is a deficiency in a number of factors of virus protection. This deficiency manifests itself through low concentration of interferon and secretory IgA in the nasal mucosa at higher levels of IL-8, alongside with low serum antiviral activity and significant inhibition of interferon production and reduction of the compensatory mechanisms of adaptive immunity. These disorders require prescription of alpha-interferon preparations. For infants and children with a burdened pre-morbid background, regardless of age, such preparations can be administered with all clinical forms of ARI; in older children — with severe forms, including complications. Alpha-interferon preparations can be introduced at in any stage of the disease. Combination therapy with alpha-interferon drugs (VIFERON® suppositories and VIFERON® ointment) allows for enhanced clinical and immunological effects of therapy.https://detinf.elpub.ru/jour/article/view/148острые респираторные инфекциипатогенезинтерфероногенезпрепараты альфа-интерферонавиферон® суппозиториивиферон® мазь |
| spellingShingle | V. V. Malinovskaya V. P. Timina L. N. Mazankova T. A. Chebotareva IMMUNOPATHOGENESIS OF ACUTE RESPIRATORY INFECTIONS AND TACTICS OF RATIONAL CHOICE OF ETIOTROPIC IMMUNOMODULATORY THERAPIES IN CHILDREN Детские инфекции (Москва) острые респираторные инфекции патогенез интерфероногенез препараты альфа-интерферона виферон® суппозитории виферон® мазь |
| title | IMMUNOPATHOGENESIS OF ACUTE RESPIRATORY INFECTIONS AND TACTICS OF RATIONAL CHOICE OF ETIOTROPIC IMMUNOMODULATORY THERAPIES IN CHILDREN |
| title_full | IMMUNOPATHOGENESIS OF ACUTE RESPIRATORY INFECTIONS AND TACTICS OF RATIONAL CHOICE OF ETIOTROPIC IMMUNOMODULATORY THERAPIES IN CHILDREN |
| title_fullStr | IMMUNOPATHOGENESIS OF ACUTE RESPIRATORY INFECTIONS AND TACTICS OF RATIONAL CHOICE OF ETIOTROPIC IMMUNOMODULATORY THERAPIES IN CHILDREN |
| title_full_unstemmed | IMMUNOPATHOGENESIS OF ACUTE RESPIRATORY INFECTIONS AND TACTICS OF RATIONAL CHOICE OF ETIOTROPIC IMMUNOMODULATORY THERAPIES IN CHILDREN |
| title_short | IMMUNOPATHOGENESIS OF ACUTE RESPIRATORY INFECTIONS AND TACTICS OF RATIONAL CHOICE OF ETIOTROPIC IMMUNOMODULATORY THERAPIES IN CHILDREN |
| title_sort | immunopathogenesis of acute respiratory infections and tactics of rational choice of etiotropic immunomodulatory therapies in children |
| topic | острые респираторные инфекции патогенез интерфероногенез препараты альфа-интерферона виферон® суппозитории виферон® мазь |
| url | https://detinf.elpub.ru/jour/article/view/148 |
| work_keys_str_mv | AT vvmalinovskaya immunopathogenesisofacuterespiratoryinfectionsandtacticsofrationalchoiceofetiotropicimmunomodulatorytherapiesinchildren AT vptimina immunopathogenesisofacuterespiratoryinfectionsandtacticsofrationalchoiceofetiotropicimmunomodulatorytherapiesinchildren AT lnmazankova immunopathogenesisofacuterespiratoryinfectionsandtacticsofrationalchoiceofetiotropicimmunomodulatorytherapiesinchildren AT tachebotareva immunopathogenesisofacuterespiratoryinfectionsandtacticsofrationalchoiceofetiotropicimmunomodulatorytherapiesinchildren |