Melanin photosensitization and the effect of visible light on epithelial cells.
Protecting human skin from sun exposure is a complex issue that involves unclear aspects of the interaction between light and tissue. A persistent misconception is that visible light is safe for the skin, although several lines of evidence suggest otherwise. Here, we show that visible light can dama...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4236153?pdf=render |
| _version_ | 1819268109609992192 |
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| author | Orlando Chiarelli-Neto Alan Silva Ferreira Waleska Kerllen Martins Christiane Pavani Divinomar Severino Fernanda Faião-Flores Silvya Stuchi Maria-Engler Eduardo Aliprandini Glaucia R Martinez Paolo Di Mascio Marisa H G Medeiros Maurício S Baptista |
| author_facet | Orlando Chiarelli-Neto Alan Silva Ferreira Waleska Kerllen Martins Christiane Pavani Divinomar Severino Fernanda Faião-Flores Silvya Stuchi Maria-Engler Eduardo Aliprandini Glaucia R Martinez Paolo Di Mascio Marisa H G Medeiros Maurício S Baptista |
| author_sort | Orlando Chiarelli-Neto |
| collection | DOAJ |
| description | Protecting human skin from sun exposure is a complex issue that involves unclear aspects of the interaction between light and tissue. A persistent misconception is that visible light is safe for the skin, although several lines of evidence suggest otherwise. Here, we show that visible light can damage melanocytes through melanin photosensitization and singlet oxygen (1O2) generation, thus decreasing cell viability, increasing membrane permeability, and causing both DNA photo-oxidation and necro-apoptotic cell death. UVA (355 nm) and visible (532 nm) light photosensitize 1O2 with similar yields, and pheomelanin is more efficient than eumelanin at generating 1O2 and resisting photobleaching. Although melanin can protect against the cellular damage induced by UVB, exposure to visible light leads to pre-mutagenic DNA lesions (i.e., Fpg- and Endo III-sensitive modifications); these DNA lesions may be mutagenic and may cause photoaging, as well as other health problems, such as skin cancer. |
| first_indexed | 2024-12-23T21:27:50Z |
| format | Article |
| id | doaj.art-6a3664b78ae04e0983f244711126fd60 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T21:27:50Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6a3664b78ae04e0983f244711126fd602022-12-21T17:30:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01911e11326610.1371/journal.pone.0113266Melanin photosensitization and the effect of visible light on epithelial cells.Orlando Chiarelli-NetoAlan Silva FerreiraWaleska Kerllen MartinsChristiane PavaniDivinomar SeverinoFernanda Faião-FloresSilvya Stuchi Maria-EnglerEduardo AliprandiniGlaucia R MartinezPaolo Di MascioMarisa H G MedeirosMaurício S BaptistaProtecting human skin from sun exposure is a complex issue that involves unclear aspects of the interaction between light and tissue. A persistent misconception is that visible light is safe for the skin, although several lines of evidence suggest otherwise. Here, we show that visible light can damage melanocytes through melanin photosensitization and singlet oxygen (1O2) generation, thus decreasing cell viability, increasing membrane permeability, and causing both DNA photo-oxidation and necro-apoptotic cell death. UVA (355 nm) and visible (532 nm) light photosensitize 1O2 with similar yields, and pheomelanin is more efficient than eumelanin at generating 1O2 and resisting photobleaching. Although melanin can protect against the cellular damage induced by UVB, exposure to visible light leads to pre-mutagenic DNA lesions (i.e., Fpg- and Endo III-sensitive modifications); these DNA lesions may be mutagenic and may cause photoaging, as well as other health problems, such as skin cancer.http://europepmc.org/articles/PMC4236153?pdf=render |
| spellingShingle | Orlando Chiarelli-Neto Alan Silva Ferreira Waleska Kerllen Martins Christiane Pavani Divinomar Severino Fernanda Faião-Flores Silvya Stuchi Maria-Engler Eduardo Aliprandini Glaucia R Martinez Paolo Di Mascio Marisa H G Medeiros Maurício S Baptista Melanin photosensitization and the effect of visible light on epithelial cells. PLoS ONE |
| title | Melanin photosensitization and the effect of visible light on epithelial cells. |
| title_full | Melanin photosensitization and the effect of visible light on epithelial cells. |
| title_fullStr | Melanin photosensitization and the effect of visible light on epithelial cells. |
| title_full_unstemmed | Melanin photosensitization and the effect of visible light on epithelial cells. |
| title_short | Melanin photosensitization and the effect of visible light on epithelial cells. |
| title_sort | melanin photosensitization and the effect of visible light on epithelial cells |
| url | http://europepmc.org/articles/PMC4236153?pdf=render |
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