Prevalence and prognostic role of mismatch repair gene defect in endometrial cancer patients
The study was to evaluate the prevalence of mismatch repair gene defect among Thai patients with endometrial cancer and its association with clinico-pathological features and survivals. The formalin fixed paraffin-embedded blocks of EMC tissue from hysterectomy specimens of patients having surgery i...
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| Format: | Article |
| Language: | English |
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IOS Press
2017-09-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317725834 |
| _version_ | 1818727838400905216 |
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| author | Siriwan Tangjitgamol Thannaporn Kittisiam Sujitra Tanvanich |
| author_facet | Siriwan Tangjitgamol Thannaporn Kittisiam Sujitra Tanvanich |
| author_sort | Siriwan Tangjitgamol |
| collection | DOAJ |
| description | The study was to evaluate the prevalence of mismatch repair gene defect among Thai patients with endometrial cancer and its association with clinico-pathological features and survivals. The formalin fixed paraffin-embedded blocks of EMC tissue from hysterectomy specimens of patients having surgery in our institution between 1 Jan 1995 and 31 December 2016 were assessed for the immunohistochemical expression of 4 mismatch repair proteins (MLH1, PMS, MSH2, MSH 6). Mismatch repair gene defect was determined by a negative expression of at least 1 protein. Among 385 EMC patients included in the study, mean age was 57.3 ± 10.8 years with 62.3% aged ⩽ 60 years. The most frequent mismatch repair gene defect was MSH6 (38.7%), followed by PMS2 (34.3%), MLH1 (33.2%), and MSH2 (16.4%). Overall, 55.1% showed negative expression of at least one protein. We found significantly higher mismatch repair gene defect in patients aged ⩽ 60 years, with early stage disease, and negative lymph node status than the other comparative groups: 59.2% vs 48.3% for age (p = 0.037), 58.2% vs 45.2% (p = 0.027) for stage, and 58.1% vs 44.6% (p = 0.048) for nodal status. The 5-year progression-free survival, overall survival, and endometrial cancer-specific survival of patients with mismatch repair gene defect was higher than those without gene defect. The differences were statistically significant for only progression-free survival and endometrial cancer-specific survival: 87.7% (95% confidence interval = 83.0%–92.4%) vs 81.5% (95% confidence interval = 75.4%–87.6%) (p = 0.049) for progression-free survival and 91.0% (95% confidence interval = 86.9%–95.1%) vs 85.5% (95% confidence interval = 80.0%–91.0%) (p = 0.044) for endometrial cancer-specific survival, respectively. In conclusion, more than half of Thai endometrial cancer patients had mismatch repair gene defect. The patients with mismatch repair gene defect had significantly younger age (⩽ 60 years) and better prognosis in terms of early stage, negative nodal status, and longer survivals. |
| first_indexed | 2024-12-17T22:20:27Z |
| format | Article |
| id | doaj.art-6a374470880844ba953bcf85fccc6117 |
| institution | Directory Open Access Journal |
| issn | 1423-0380 |
| language | English |
| last_indexed | 2024-12-17T22:20:27Z |
| publishDate | 2017-09-01 |
| publisher | IOS Press |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj.art-6a374470880844ba953bcf85fccc61172022-12-21T21:30:29ZengIOS PressTumor Biology1423-03802017-09-013910.1177/1010428317725834Prevalence and prognostic role of mismatch repair gene defect in endometrial cancer patientsSiriwan Tangjitgamol0Thannaporn Kittisiam1Sujitra Tanvanich2Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, ThailandDepartment of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, ThailandDepartment of Anatomical Pathology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, ThailandThe study was to evaluate the prevalence of mismatch repair gene defect among Thai patients with endometrial cancer and its association with clinico-pathological features and survivals. The formalin fixed paraffin-embedded blocks of EMC tissue from hysterectomy specimens of patients having surgery in our institution between 1 Jan 1995 and 31 December 2016 were assessed for the immunohistochemical expression of 4 mismatch repair proteins (MLH1, PMS, MSH2, MSH 6). Mismatch repair gene defect was determined by a negative expression of at least 1 protein. Among 385 EMC patients included in the study, mean age was 57.3 ± 10.8 years with 62.3% aged ⩽ 60 years. The most frequent mismatch repair gene defect was MSH6 (38.7%), followed by PMS2 (34.3%), MLH1 (33.2%), and MSH2 (16.4%). Overall, 55.1% showed negative expression of at least one protein. We found significantly higher mismatch repair gene defect in patients aged ⩽ 60 years, with early stage disease, and negative lymph node status than the other comparative groups: 59.2% vs 48.3% for age (p = 0.037), 58.2% vs 45.2% (p = 0.027) for stage, and 58.1% vs 44.6% (p = 0.048) for nodal status. The 5-year progression-free survival, overall survival, and endometrial cancer-specific survival of patients with mismatch repair gene defect was higher than those without gene defect. The differences were statistically significant for only progression-free survival and endometrial cancer-specific survival: 87.7% (95% confidence interval = 83.0%–92.4%) vs 81.5% (95% confidence interval = 75.4%–87.6%) (p = 0.049) for progression-free survival and 91.0% (95% confidence interval = 86.9%–95.1%) vs 85.5% (95% confidence interval = 80.0%–91.0%) (p = 0.044) for endometrial cancer-specific survival, respectively. In conclusion, more than half of Thai endometrial cancer patients had mismatch repair gene defect. The patients with mismatch repair gene defect had significantly younger age (⩽ 60 years) and better prognosis in terms of early stage, negative nodal status, and longer survivals.https://doi.org/10.1177/1010428317725834 |
| spellingShingle | Siriwan Tangjitgamol Thannaporn Kittisiam Sujitra Tanvanich Prevalence and prognostic role of mismatch repair gene defect in endometrial cancer patients Tumor Biology |
| title | Prevalence and prognostic role of mismatch repair gene defect in endometrial cancer patients |
| title_full | Prevalence and prognostic role of mismatch repair gene defect in endometrial cancer patients |
| title_fullStr | Prevalence and prognostic role of mismatch repair gene defect in endometrial cancer patients |
| title_full_unstemmed | Prevalence and prognostic role of mismatch repair gene defect in endometrial cancer patients |
| title_short | Prevalence and prognostic role of mismatch repair gene defect in endometrial cancer patients |
| title_sort | prevalence and prognostic role of mismatch repair gene defect in endometrial cancer patients |
| url | https://doi.org/10.1177/1010428317725834 |
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