Treatment Outcome of Cervical Cancer Patients in the Elderly Population Aged 80 Years and Above: A Single Institution Study
Introduction: Age-related deficits such as malnutrition, functional reliance, and cognitive decline also occur in older women, as they are typically weaker and have many co-morbid conditions like diabetes or cardiac illness. These prognostic factors might predict overall survival and progression...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2023-09-01
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Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://www.jcdr.net/articles/PDF/18476/63794_CE[Ra1]_F_(SS)_QC(KK_IS)_PF1(HB_SS_KM)_PFA_NC(HB_KM)_PN(KM).pdf |
Summary: | Introduction: Age-related deficits such as malnutrition, functional
reliance, and cognitive decline also occur in older women, as
they are typically weaker and have many co-morbid conditions
like diabetes or cardiac illness. These prognostic factors might
predict overall survival and progression-free survival.
Aim: To analyse the management outcomes of elderly
patients with cervical carcinoma treated with radiotherapy and
brachytherapy.
Materials and Methods: A retrospective observational study
was conducted in the Department of Radiation Oncology at
Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand,
India. Medical records were collected from 876 patients with
cervical cancer who had been treated with radiotherapy or
combined radiotherapy and chemotherapy from January 2009 to
December 2021. A total of 876 patients presented with cervical
cancer in the Outpatient Department (OPD), and 20 patients
meeting the inclusion criteria were selected. Patients diagnosed
with cervical cancer, Federation International Federation of
Gynaecology and Obstetrics (FIGO) stage IB to IVA, aged equal to
or greater than 80 years old, and Eastern Cooperative Oncology
Group (ECOG) performance status I to III were considered for
inclusion. Categorical variables were expressed as counts and
percentages. The following clinicopathological characteristics
of the study population were examined: FIGO staging,
including stage IB to stage IVA, histopathological features of
adenocarcinoma, squamous carcinoma, or adenosquamous
carcinoma, doses of radiotherapy and brachytherapy, overall
survival, disease-free survival, and the patient’s current status
(alive or dead) was determined. If death occurred, the cause of
death was determined. The Kaplan-Meier approach was used
to analyse overall survival and disease-free survival in the study
population using XLSTAT statistical software.
Results: The study population was age standardised, with 18
patients (90%) falling between the ages of 80 and 85, and 2
patients (10%) falling between the ages of 86 and 90. A total
of 12 patients (60%) belonged to ECOG PS II. A total of 19
(95%) patients had histologically confirmed squamous cell
carcinoma. 75% of the population was in a locally advanced
stage (stage III-IVA). The overall survival (in months) was 65.58
months, which was statistically significant (p<0.0083). Similarly,
the average disease-free interval was 38.73 months, which was
also significant (p<0.0062).
Conclusion: According to the findings of the study, age may
not be an independent risk factor for determining the outcome
of cervical cancer patients in the Indian scenario. Even though
elderly females may present with multiple co-morbidities, the
standard treatment protocol must be radical. |
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ISSN: | 2249-782X 0973-709X |