The traditional use, structure, and immunostimulatory activity of bioactive polysaccharides from traditional Chinese root medicines: A review
As research on traditional Chinese medicine (TCM) has expanded, our understanding of the role it can have in controlling the immune system has increased. Polysaccharides from medicinal plants exhibit numerous beneficial therapeutic properties, presumably owing to their modulation of innate immunity...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023108012 |
| _version_ | 1797336963927244800 |
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| author | Surina Bo Man Zhang Mu Dan |
| author_facet | Surina Bo Man Zhang Mu Dan |
| author_sort | Surina Bo |
| collection | DOAJ |
| description | As research on traditional Chinese medicine (TCM) has expanded, our understanding of the role it can have in controlling the immune system has increased. Polysaccharides from medicinal plants exhibit numerous beneficial therapeutic properties, presumably owing to their modulation of innate immunity and macrophage function. Numerous studies have demonstrated the multiple ways whereby certain polysaccharides can affect the immune system. In addition to stimulating immune cells, such as T cells, B lymphocytes, macrophages, and natural killer cells, polysaccharides stimulate complements and increase cytokine secretion. The biological functions of polysaccharides are directly correlated with their structures. This paper summarizes the sources, TCM uses, extraction and purification methods, structural characterization, in vitro and in vivo immune activities, and underlying molecular mechanisms of TCM root polysaccharides. Moreover, the structure–activity relationships of TCM root polysaccharides are emphasized and discussed. This review can provide a scientific basis for the research and industrial utilization of TCM root polysaccharides. |
| first_indexed | 2024-03-08T09:02:30Z |
| format | Article |
| id | doaj.art-6a388d8fdd6945a98d8ee56001acfd7b |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T09:02:30Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-6a388d8fdd6945a98d8ee56001acfd7b2024-02-01T06:32:34ZengElsevierHeliyon2405-84402024-01-01101e23593The traditional use, structure, and immunostimulatory activity of bioactive polysaccharides from traditional Chinese root medicines: A reviewSurina Bo0Man Zhang1Mu Dan2Corresponding author. College of Pharmacy, Inner Mongolia Medical University, Jinshan Development Zone, Hohhot, Inner Mongolia, 010110, PR China.; College of Pharmacy, Inner Mongolia Medical University, Jinshan Development Zone, Hohhot, Inner Mongolia, 010110, PR ChinaCollege of Pharmacy, Inner Mongolia Medical University, Jinshan Development Zone, Hohhot, Inner Mongolia, 010110, PR ChinaCollege of Pharmacy, Inner Mongolia Medical University, Jinshan Development Zone, Hohhot, Inner Mongolia, 010110, PR ChinaAs research on traditional Chinese medicine (TCM) has expanded, our understanding of the role it can have in controlling the immune system has increased. Polysaccharides from medicinal plants exhibit numerous beneficial therapeutic properties, presumably owing to their modulation of innate immunity and macrophage function. Numerous studies have demonstrated the multiple ways whereby certain polysaccharides can affect the immune system. In addition to stimulating immune cells, such as T cells, B lymphocytes, macrophages, and natural killer cells, polysaccharides stimulate complements and increase cytokine secretion. The biological functions of polysaccharides are directly correlated with their structures. This paper summarizes the sources, TCM uses, extraction and purification methods, structural characterization, in vitro and in vivo immune activities, and underlying molecular mechanisms of TCM root polysaccharides. Moreover, the structure–activity relationships of TCM root polysaccharides are emphasized and discussed. This review can provide a scientific basis for the research and industrial utilization of TCM root polysaccharides.http://www.sciencedirect.com/science/article/pii/S2405844023108012Traditional Chinese root medicinesBioactive polysaccharidesStructureImmunostimulatory activity |
| spellingShingle | Surina Bo Man Zhang Mu Dan The traditional use, structure, and immunostimulatory activity of bioactive polysaccharides from traditional Chinese root medicines: A review Heliyon Traditional Chinese root medicines Bioactive polysaccharides Structure Immunostimulatory activity |
| title | The traditional use, structure, and immunostimulatory activity of bioactive polysaccharides from traditional Chinese root medicines: A review |
| title_full | The traditional use, structure, and immunostimulatory activity of bioactive polysaccharides from traditional Chinese root medicines: A review |
| title_fullStr | The traditional use, structure, and immunostimulatory activity of bioactive polysaccharides from traditional Chinese root medicines: A review |
| title_full_unstemmed | The traditional use, structure, and immunostimulatory activity of bioactive polysaccharides from traditional Chinese root medicines: A review |
| title_short | The traditional use, structure, and immunostimulatory activity of bioactive polysaccharides from traditional Chinese root medicines: A review |
| title_sort | traditional use structure and immunostimulatory activity of bioactive polysaccharides from traditional chinese root medicines a review |
| topic | Traditional Chinese root medicines Bioactive polysaccharides Structure Immunostimulatory activity |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023108012 |
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