The Influence of Triclosan on the Thyroid Hormone System in Humans - A Systematic Review
ObjectivesTriclosan is an antibacterial agent suspected to disrupt the endocrine system. The aim of this study was to investigate the influence of triclosan on the human thyroid system through a systematic literature review of human studies.MethodsEligibility criteria and method of analysis were reg...
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| Format: | Article |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.883827/full |
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| author | Mai Homburg Åse Krogh Rasmussen Louise Ramhøj Ulla Feldt-Rasmussen Ulla Feldt-Rasmussen |
| author_facet | Mai Homburg Åse Krogh Rasmussen Louise Ramhøj Ulla Feldt-Rasmussen Ulla Feldt-Rasmussen |
| author_sort | Mai Homburg |
| collection | DOAJ |
| description | ObjectivesTriclosan is an antibacterial agent suspected to disrupt the endocrine system. The aim of this study was to investigate the influence of triclosan on the human thyroid system through a systematic literature review of human studies.MethodsEligibility criteria and method of analysis were registered at Prospero (registration number: CRD42019120984) before a systematic search was conducted in Pubmed and Embase in October 2020. Seventeen articles were found eligible for inclusion. Thirteen studies were observational, while four had a triclosan intervention. Participants consisted of pregnant women in eight studies, of men and non-pregnant women in seven studies and of chord samples/newborns/children/adolescents in six studies. The outcomes were peripheral thyroid hormones and thyroid-stimulating hormone (TSH) in blood samples.ResultsSeveral studies found a negative association between triclosan and triiodothyronine and thyroxine, and a positive association with TSH; however, the opposite associations or no associations were also found. In general, the studies had limited measurement timepoints of thyroid outcomes, and the interventional studies used low concentrations of triclosan. Thus, study design limitations influence the quality of the dataset and it is not yet possible to conclude whether triclosan at current human exposure levels adversely affects the thyroid hormone system.ConclusionsFurther larger studies with more continuity and more elaborate outcome measurements of thyroid function are needed to clarify whether triclosan, at current exposure levels, affects the human thyroid hormone system.Systematic Review Registrationhttp://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42019120984, identifier PROSPERO (CRD42019120984). |
| first_indexed | 2024-04-13T22:56:37Z |
| format | Article |
| id | doaj.art-6a38e9cfeeaa474792cb51ebe29c4f9d |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-13T22:56:37Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-6a38e9cfeeaa474792cb51ebe29c4f9d2022-12-22T02:25:58ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-06-011310.3389/fendo.2022.883827883827The Influence of Triclosan on the Thyroid Hormone System in Humans - A Systematic ReviewMai Homburg0Åse Krogh Rasmussen1Louise Ramhøj2Ulla Feldt-Rasmussen3Ulla Feldt-Rasmussen4Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital, Copenhagen, DenmarkDepartment of Medical Endocrinology and Metabolism, Copenhagen University Hospital, Copenhagen, DenmarkNational Food Institute, Technical University of Denmark, Kgs. Lyngby, DenmarkDepartment of Medical Endocrinology and Metabolism, Copenhagen University Hospital, Copenhagen, DenmarkDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkObjectivesTriclosan is an antibacterial agent suspected to disrupt the endocrine system. The aim of this study was to investigate the influence of triclosan on the human thyroid system through a systematic literature review of human studies.MethodsEligibility criteria and method of analysis were registered at Prospero (registration number: CRD42019120984) before a systematic search was conducted in Pubmed and Embase in October 2020. Seventeen articles were found eligible for inclusion. Thirteen studies were observational, while four had a triclosan intervention. Participants consisted of pregnant women in eight studies, of men and non-pregnant women in seven studies and of chord samples/newborns/children/adolescents in six studies. The outcomes were peripheral thyroid hormones and thyroid-stimulating hormone (TSH) in blood samples.ResultsSeveral studies found a negative association between triclosan and triiodothyronine and thyroxine, and a positive association with TSH; however, the opposite associations or no associations were also found. In general, the studies had limited measurement timepoints of thyroid outcomes, and the interventional studies used low concentrations of triclosan. Thus, study design limitations influence the quality of the dataset and it is not yet possible to conclude whether triclosan at current human exposure levels adversely affects the thyroid hormone system.ConclusionsFurther larger studies with more continuity and more elaborate outcome measurements of thyroid function are needed to clarify whether triclosan, at current exposure levels, affects the human thyroid hormone system.Systematic Review Registrationhttp://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42019120984, identifier PROSPERO (CRD42019120984).https://www.frontiersin.org/articles/10.3389/fendo.2022.883827/fulltriclosanthyroidendocrine disrupting chemicalshealththyroid toxicityenvironment |
| spellingShingle | Mai Homburg Åse Krogh Rasmussen Louise Ramhøj Ulla Feldt-Rasmussen Ulla Feldt-Rasmussen The Influence of Triclosan on the Thyroid Hormone System in Humans - A Systematic Review Frontiers in Endocrinology triclosan thyroid endocrine disrupting chemicals health thyroid toxicity environment |
| title | The Influence of Triclosan on the Thyroid Hormone System in Humans - A Systematic Review |
| title_full | The Influence of Triclosan on the Thyroid Hormone System in Humans - A Systematic Review |
| title_fullStr | The Influence of Triclosan on the Thyroid Hormone System in Humans - A Systematic Review |
| title_full_unstemmed | The Influence of Triclosan on the Thyroid Hormone System in Humans - A Systematic Review |
| title_short | The Influence of Triclosan on the Thyroid Hormone System in Humans - A Systematic Review |
| title_sort | influence of triclosan on the thyroid hormone system in humans a systematic review |
| topic | triclosan thyroid endocrine disrupting chemicals health thyroid toxicity environment |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.883827/full |
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