Orthodontics Surgical Assistance (Piezosurgery<sup>®</sup>): Experimental Evidence According to Clinical Results
Orthodontic tooth movement (OTM) is based on intermitted or continuous forces applied to teeth, changing the mechanical loading of the system and arousing a cellular response that leads to bone adaptation. The traditional orthodontic movement causes a remodeling of the alveolar bone and changes in t...
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MDPI AG
2022-01-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/12/3/1048 |
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| author | Dario Bertossi Dario Donadello Giamaica Conti Luca Calogero Carletta Andrea Sbarbati Claudia Corega Alessandra Luise Marie Magistretti Alessandra Lucchese Giovanni Salzano Giulia Ricciardi Pier Francesco Nocini |
| author_facet | Dario Bertossi Dario Donadello Giamaica Conti Luca Calogero Carletta Andrea Sbarbati Claudia Corega Alessandra Luise Marie Magistretti Alessandra Lucchese Giovanni Salzano Giulia Ricciardi Pier Francesco Nocini |
| author_sort | Dario Bertossi |
| collection | DOAJ |
| description | Orthodontic tooth movement (OTM) is based on intermitted or continuous forces applied to teeth, changing the mechanical loading of the system and arousing a cellular response that leads to bone adaptation. The traditional orthodontic movement causes a remodeling of the alveolar bone and changes in the periodontal structures that lead to tooth movement. The use of a piezoelectric instrument in orthodontic surgery has already shown great advantages. The purpose of this study is to rank the behavior of inflammatory mediators in accelerating orthodontic tooth movement. Ten patients with malocclusion underwent orthodontic surgical treatment, which included a first stage of surgically guided orthodontic movement (monocortical tooth dislocation and ligament distraction, MTDLD) to accelerate orthodontic movements. In all cases, corticotomy was performed by Piezosurgery. Bone and dental biopsy was executed to evaluate changes in the cytokines IL-1beta, TNF-alpha and IL-2 in different time intervals (1, 2, 7, 14 and 28 days). The molecular mediators are IL-1 beta, TNF-alpha and IL-2. Immediately after the surgical procedure there was a mild expression of the three molecular markers, while the assertion of IL-1 beta and TNF-alpha reached the maximum value after 24 h and 48 h, indicating a strong activation of the treated tissues. The Piezosurgery<sup>®</sup> surgical technique induces an evident stress in short times, within 24–48 h from the treatment, but it decreases significantly during the follow-up. |
| first_indexed | 2024-03-10T00:15:57Z |
| format | Article |
| id | doaj.art-6a3a70fa3a0b4ee4833837d8d0f2204c |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T00:15:57Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-6a3a70fa3a0b4ee4833837d8d0f2204c2023-11-23T15:51:00ZengMDPI AGApplied Sciences2076-34172022-01-01123104810.3390/app12031048Orthodontics Surgical Assistance (Piezosurgery<sup>®</sup>): Experimental Evidence According to Clinical ResultsDario Bertossi0Dario Donadello1Giamaica Conti2Luca Calogero Carletta3Andrea Sbarbati4Claudia Corega5Alessandra Luise Marie Magistretti6Alessandra Lucchese7Giovanni Salzano8Giulia Ricciardi9Pier Francesco Nocini10Section of Oral and Maxillofacial Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Policlinico G.B. Rossi Piazzale L. Scuro, 37134 Verona, ItalySection of Oral and Maxillofacial Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Policlinico G.B. Rossi Piazzale L. Scuro, 37134 Verona, ItalyDepartment of Neurosciences, Biomedicine and Movement Sciences, Anatomy and Histology Division, University of Verona, 37134 Verona, ItalySection of Oral and Maxillofacial Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Policlinico G.B. Rossi Piazzale L. Scuro, 37134 Verona, ItalyDepartment of Neurosciences, Biomedicine and Movement Sciences, Anatomy and Histology Division, University of Verona, 37134 Verona, ItalyDepartment of Orthodontics, Faculty of Dentistry, University of Medicine and Pharmacy Cluj-Napoca, 400000 Cluj-Napoca, RomaniaFaculté de Biologie et de Médecine, Ecole de Médecine, Université de Lausanne, CH-1011 Lausanne, SwitzerlandUnit of Orthodontics, Division of Dentistry IRCCS Ospedale San Raffaele Scientific Institute, 20132 Milan, ItalyDivision of Maxillo-Facial and ENT Oncological Surgery, Istituto Nazionale Tumori, IRCCS Fondazione G. Pascale, Via M. Semmola 52, 80131 Naples, ItalySection of Oral and Maxillofacial Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Policlinico G.B. Rossi Piazzale L. Scuro, 37134 Verona, ItalySection of Oral and Maxillofacial Surgery, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Policlinico G.B. Rossi Piazzale L. Scuro, 37134 Verona, ItalyOrthodontic tooth movement (OTM) is based on intermitted or continuous forces applied to teeth, changing the mechanical loading of the system and arousing a cellular response that leads to bone adaptation. The traditional orthodontic movement causes a remodeling of the alveolar bone and changes in the periodontal structures that lead to tooth movement. The use of a piezoelectric instrument in orthodontic surgery has already shown great advantages. The purpose of this study is to rank the behavior of inflammatory mediators in accelerating orthodontic tooth movement. Ten patients with malocclusion underwent orthodontic surgical treatment, which included a first stage of surgically guided orthodontic movement (monocortical tooth dislocation and ligament distraction, MTDLD) to accelerate orthodontic movements. In all cases, corticotomy was performed by Piezosurgery. Bone and dental biopsy was executed to evaluate changes in the cytokines IL-1beta, TNF-alpha and IL-2 in different time intervals (1, 2, 7, 14 and 28 days). The molecular mediators are IL-1 beta, TNF-alpha and IL-2. Immediately after the surgical procedure there was a mild expression of the three molecular markers, while the assertion of IL-1 beta and TNF-alpha reached the maximum value after 24 h and 48 h, indicating a strong activation of the treated tissues. The Piezosurgery<sup>®</sup> surgical technique induces an evident stress in short times, within 24–48 h from the treatment, but it decreases significantly during the follow-up.https://www.mdpi.com/2076-3417/12/3/1048Piezosurgeryorthodonticscytokines |
| spellingShingle | Dario Bertossi Dario Donadello Giamaica Conti Luca Calogero Carletta Andrea Sbarbati Claudia Corega Alessandra Luise Marie Magistretti Alessandra Lucchese Giovanni Salzano Giulia Ricciardi Pier Francesco Nocini Orthodontics Surgical Assistance (Piezosurgery<sup>®</sup>): Experimental Evidence According to Clinical Results Applied Sciences Piezosurgery orthodontics cytokines |
| title | Orthodontics Surgical Assistance (Piezosurgery<sup>®</sup>): Experimental Evidence According to Clinical Results |
| title_full | Orthodontics Surgical Assistance (Piezosurgery<sup>®</sup>): Experimental Evidence According to Clinical Results |
| title_fullStr | Orthodontics Surgical Assistance (Piezosurgery<sup>®</sup>): Experimental Evidence According to Clinical Results |
| title_full_unstemmed | Orthodontics Surgical Assistance (Piezosurgery<sup>®</sup>): Experimental Evidence According to Clinical Results |
| title_short | Orthodontics Surgical Assistance (Piezosurgery<sup>®</sup>): Experimental Evidence According to Clinical Results |
| title_sort | orthodontics surgical assistance piezosurgery sup r sup experimental evidence according to clinical results |
| topic | Piezosurgery orthodontics cytokines |
| url | https://www.mdpi.com/2076-3417/12/3/1048 |
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