Analogue closed-loop optogenetic modulation of hippocampal pyramidal cells dissociates gamma frequency and amplitude
Gamma-band oscillations are implicated in modulation of attention, integration of sensory information and flexible communication among anatomically connected brain areas. How networks become entrained is incompletely understood. Specifically, it is unclear how the spectral and temporal characteristi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-10-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/38346 |
| _version_ | 1811200753374593024 |
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| author | Elizabeth Nicholson Dmitry A Kuzmin Marco Leite Thomas E Akam Dimitri Michael Kullmann |
| author_facet | Elizabeth Nicholson Dmitry A Kuzmin Marco Leite Thomas E Akam Dimitri Michael Kullmann |
| author_sort | Elizabeth Nicholson |
| collection | DOAJ |
| description | Gamma-band oscillations are implicated in modulation of attention, integration of sensory information and flexible communication among anatomically connected brain areas. How networks become entrained is incompletely understood. Specifically, it is unclear how the spectral and temporal characteristics of network oscillations can be altered on rapid timescales needed for efficient communication. We use closed-loop optogenetic modulation of principal cell excitability in mouse hippocampal slices to interrogate the dynamical properties of hippocampal oscillations. Gamma frequency and amplitude can be modulated bi-directionally, and dissociated, by phase-advancing or delaying optogenetic feedback to pyramidal cells. Closed-loop modulation alters the synchrony rather than average frequency of action potentials, in principle avoiding disruption of population rate-coding of information. Modulation of phasic excitatory currents in principal neurons is sufficient to manipulate oscillations, suggesting that feed-forward excitation of pyramidal cells has an important role in determining oscillatory dynamics and the ability of networks to couple with one another. |
| first_indexed | 2024-04-12T02:08:59Z |
| format | Article |
| id | doaj.art-6a3ac2e32c0840568f714b645fefa24a |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:08:59Z |
| publishDate | 2018-10-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-6a3ac2e32c0840568f714b645fefa24a2022-12-22T03:52:27ZengeLife Sciences Publications LtdeLife2050-084X2018-10-01710.7554/eLife.38346Analogue closed-loop optogenetic modulation of hippocampal pyramidal cells dissociates gamma frequency and amplitudeElizabeth Nicholson0Dmitry A Kuzmin1Marco Leite2Thomas E Akam3https://orcid.org/0000-0002-1810-0494Dimitri Michael Kullmann4https://orcid.org/0000-0001-6696-3545UCL Institute of Neurology, University College London, London, United KingdomUCL Institute of Neurology, University College London, London, United KingdomUCL Institute of Neurology, University College London, London, United KingdomChampalimaud Neuroscience Program, Champalimaud Center for the Unknown, Lisbon, PortugalUCL Institute of Neurology, University College London, London, United KingdomGamma-band oscillations are implicated in modulation of attention, integration of sensory information and flexible communication among anatomically connected brain areas. How networks become entrained is incompletely understood. Specifically, it is unclear how the spectral and temporal characteristics of network oscillations can be altered on rapid timescales needed for efficient communication. We use closed-loop optogenetic modulation of principal cell excitability in mouse hippocampal slices to interrogate the dynamical properties of hippocampal oscillations. Gamma frequency and amplitude can be modulated bi-directionally, and dissociated, by phase-advancing or delaying optogenetic feedback to pyramidal cells. Closed-loop modulation alters the synchrony rather than average frequency of action potentials, in principle avoiding disruption of population rate-coding of information. Modulation of phasic excitatory currents in principal neurons is sufficient to manipulate oscillations, suggesting that feed-forward excitation of pyramidal cells has an important role in determining oscillatory dynamics and the ability of networks to couple with one another.https://elifesciences.org/articles/38346gamma oscillationsphase response curveclosed-loop |
| spellingShingle | Elizabeth Nicholson Dmitry A Kuzmin Marco Leite Thomas E Akam Dimitri Michael Kullmann Analogue closed-loop optogenetic modulation of hippocampal pyramidal cells dissociates gamma frequency and amplitude eLife gamma oscillations phase response curve closed-loop |
| title | Analogue closed-loop optogenetic modulation of hippocampal pyramidal cells dissociates gamma frequency and amplitude |
| title_full | Analogue closed-loop optogenetic modulation of hippocampal pyramidal cells dissociates gamma frequency and amplitude |
| title_fullStr | Analogue closed-loop optogenetic modulation of hippocampal pyramidal cells dissociates gamma frequency and amplitude |
| title_full_unstemmed | Analogue closed-loop optogenetic modulation of hippocampal pyramidal cells dissociates gamma frequency and amplitude |
| title_short | Analogue closed-loop optogenetic modulation of hippocampal pyramidal cells dissociates gamma frequency and amplitude |
| title_sort | analogue closed loop optogenetic modulation of hippocampal pyramidal cells dissociates gamma frequency and amplitude |
| topic | gamma oscillations phase response curve closed-loop |
| url | https://elifesciences.org/articles/38346 |
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