First identification of bovine hepacivirus in wild boars
Abstract Hepatitis C virus (HCV) is a major cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma in humans. Humans were long considered the only hosts of Hepacivirus. Recently HCV-like sequences have been found in several animal species. Hepaciviruses are considered species-specific bu...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-15928-7 |
| _version_ | 1811224072537767936 |
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| author | Claudio de Martinis Lorena Cardillo Claudia Esposito Maurizio Viscardi Lorella Barca Stefania Cavallo Nicola D’Alessio Vito Martella Giovanna Fusco |
| author_facet | Claudio de Martinis Lorena Cardillo Claudia Esposito Maurizio Viscardi Lorella Barca Stefania Cavallo Nicola D’Alessio Vito Martella Giovanna Fusco |
| author_sort | Claudio de Martinis |
| collection | DOAJ |
| description | Abstract Hepatitis C virus (HCV) is a major cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma in humans. Humans were long considered the only hosts of Hepacivirus. Recently HCV-like sequences have been found in several animal species. Hepaciviruses are considered species-specific but a wider host range and a zoonotic role has been hypothesized. We report the first detection of bovine hepacivirus (BovHepV) sequences in wild boars. A total of 310 wild boars hunted in Campania region were investigated with a pan-hepacivirus nested-PCR protocol for the NS3 gene. Hepacivirus RNA was detected in 5.8% of the animals. Sequence and phylogenetic analysis showed high homology with BovHepV subtype F, with nucleotide identity of 99%. The positive wild boars were georeferenced, revealing high density of livestock farms, with no clear distinction between animal husbandry and hunting areas. These findings might suggest the ability of BovHepV to cross the host-species barrier and infect wild boars. |
| first_indexed | 2024-04-12T08:43:52Z |
| format | Article |
| id | doaj.art-6a3b89c32bc14f1ea6b38052289592ee |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T08:43:52Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6a3b89c32bc14f1ea6b38052289592ee2022-12-22T03:39:47ZengNature PortfolioScientific Reports2045-23222022-07-011211610.1038/s41598-022-15928-7First identification of bovine hepacivirus in wild boarsClaudio de Martinis0Lorena Cardillo1Claudia Esposito2Maurizio Viscardi3Lorella Barca4Stefania Cavallo5Nicola D’Alessio6Vito Martella7Giovanna Fusco8Unit of Exotic and Vector-Borne Diseases, Department of Animal Health, Istituto Zooprofilattico Sperimentale del MezzogiornoUnit of Exotic and Vector-Borne Diseases, Department of Animal Health, Istituto Zooprofilattico Sperimentale del MezzogiornoUnit of Exotic and Vector-Borne Diseases, Department of Animal Health, Istituto Zooprofilattico Sperimentale del MezzogiornoUnit of Exotic and Vector-Borne Diseases, Department of Animal Health, Istituto Zooprofilattico Sperimentale del MezzogiornoIstituto Zooprofilattico Sperimentale del Mezzogiorno, Calabria SectionDepartment of Epidemiologic and Biostatistic Regional Observatory (OREB), Istituto Zooprofilattico Sperimentale del MezzogiornoUnit of Exotic and Vector-Borne Diseases, Department of Animal Health, Istituto Zooprofilattico Sperimentale del MezzogiornoDepartment of Veterinary Medicine, Aldo Moro” UniversityUnit of Exotic and Vector-Borne Diseases, Department of Animal Health, Istituto Zooprofilattico Sperimentale del MezzogiornoAbstract Hepatitis C virus (HCV) is a major cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma in humans. Humans were long considered the only hosts of Hepacivirus. Recently HCV-like sequences have been found in several animal species. Hepaciviruses are considered species-specific but a wider host range and a zoonotic role has been hypothesized. We report the first detection of bovine hepacivirus (BovHepV) sequences in wild boars. A total of 310 wild boars hunted in Campania region were investigated with a pan-hepacivirus nested-PCR protocol for the NS3 gene. Hepacivirus RNA was detected in 5.8% of the animals. Sequence and phylogenetic analysis showed high homology with BovHepV subtype F, with nucleotide identity of 99%. The positive wild boars were georeferenced, revealing high density of livestock farms, with no clear distinction between animal husbandry and hunting areas. These findings might suggest the ability of BovHepV to cross the host-species barrier and infect wild boars.https://doi.org/10.1038/s41598-022-15928-7 |
| spellingShingle | Claudio de Martinis Lorena Cardillo Claudia Esposito Maurizio Viscardi Lorella Barca Stefania Cavallo Nicola D’Alessio Vito Martella Giovanna Fusco First identification of bovine hepacivirus in wild boars Scientific Reports |
| title | First identification of bovine hepacivirus in wild boars |
| title_full | First identification of bovine hepacivirus in wild boars |
| title_fullStr | First identification of bovine hepacivirus in wild boars |
| title_full_unstemmed | First identification of bovine hepacivirus in wild boars |
| title_short | First identification of bovine hepacivirus in wild boars |
| title_sort | first identification of bovine hepacivirus in wild boars |
| url | https://doi.org/10.1038/s41598-022-15928-7 |
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