Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interaction
Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) function as postsynaptic organizers that induce excitatory synapses. Here authors solve the crystal structure of LRRTM2 in complex with its ligand Nrxn1β and shed light on how selective binding of ligands to LRRTM1/2 is achieved.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06333-8 |
| _version_ | 1818994708303577088 |
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| author | Atsushi Yamagata Sakurako Goto-Ito Yusuke Sato Tomoko Shiroshima Asami Maeda Masahiko Watanabe Takashi Saitoh Katsumi Maenaka Tohru Terada Tomoyuki Yoshida Takeshi Uemura Shuya Fukai |
| author_facet | Atsushi Yamagata Sakurako Goto-Ito Yusuke Sato Tomoko Shiroshima Asami Maeda Masahiko Watanabe Takashi Saitoh Katsumi Maenaka Tohru Terada Tomoyuki Yoshida Takeshi Uemura Shuya Fukai |
| author_sort | Atsushi Yamagata |
| collection | DOAJ |
| description | Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) function as postsynaptic organizers that induce excitatory synapses. Here authors solve the crystal structure of LRRTM2 in complex with its ligand Nrxn1β and shed light on how selective binding of ligands to LRRTM1/2 is achieved. |
| first_indexed | 2024-12-20T21:02:14Z |
| format | Article |
| id | doaj.art-6a3dc0e46ef84edea9ccf79ebc62bca0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T21:02:14Z |
| publishDate | 2018-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6a3dc0e46ef84edea9ccf79ebc62bca02022-12-21T19:26:40ZengNature PortfolioNature Communications2041-17232018-09-019111110.1038/s41467-018-06333-8Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interactionAtsushi Yamagata0Sakurako Goto-Ito1Yusuke Sato2Tomoko Shiroshima3Asami Maeda4Masahiko Watanabe5Takashi Saitoh6Katsumi Maenaka7Tohru Terada8Tomoyuki Yoshida9Takeshi Uemura10Shuya Fukai11Institute for Quantitative Biosciences, The University of TokyoInstitute for Quantitative Biosciences, The University of TokyoInstitute for Quantitative Biosciences, The University of TokyoInstitute for Quantitative Biosciences, The University of TokyoInstitute for Quantitative Biosciences, The University of TokyoDepartment of Anatomy, Hokkaido University Faculty of MedicineDepartment of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Hokkaido University of ScienceCenter for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido UniversityInterfaculty Initiative in Information Studies, The University of TokyoDepartment of Molecular Neuroscience, Graduate School of Medicine and Pharmaceutical Sciences, University of ToyamaCREST, JSTInstitute for Quantitative Biosciences, The University of TokyoLeucine-rich repeat transmembrane neuronal proteins (LRRTMs) function as postsynaptic organizers that induce excitatory synapses. Here authors solve the crystal structure of LRRTM2 in complex with its ligand Nrxn1β and shed light on how selective binding of ligands to LRRTM1/2 is achieved.https://doi.org/10.1038/s41467-018-06333-8 |
| spellingShingle | Atsushi Yamagata Sakurako Goto-Ito Yusuke Sato Tomoko Shiroshima Asami Maeda Masahiko Watanabe Takashi Saitoh Katsumi Maenaka Tohru Terada Tomoyuki Yoshida Takeshi Uemura Shuya Fukai Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interaction Nature Communications |
| title | Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interaction |
| title_full | Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interaction |
| title_fullStr | Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interaction |
| title_full_unstemmed | Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interaction |
| title_short | Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interaction |
| title_sort | structural insights into modulation and selectivity of transsynaptic neurexin lrrtm interaction |
| url | https://doi.org/10.1038/s41467-018-06333-8 |
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