EUS-guided tissue acquisition in the study of the adrenal glands: Results of a nationwide multicenter study.
<h4>Background</h4>There are limited data about the role of endoscopic ultrasound-guided tissue acquisition (EUS-TA), by fine needle aspiration (EUS-FNA) or biopsy (EUS-FNB), in the evaluation of the adrenal glands (AG). The primary aim was to assess the diagnostic yield and safety. The...
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0216658 |
| _version_ | 1819028612492296192 |
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| author | A Martin-Cardona G Fernandez-Esparrach J C Subtil J Iglesias-Garcia M Garcia-Guix A Barturen Barroso A Z Gimeno-Garcia J M Esteban A Pardo Balteiro A Velasco-Guardado E Vazquez-Sequeiros C Loras B Martinez-Moreno A Castellot C Huertas M Martinez-Lapiedra A Sanchez-Yague A Teran V J Morales-Alvarado M Betes D de la Iglesia C Sánchez-Montes M D Lozano J Lariño-Noia A Gines C Tebe J B Gornals On belhaf of Spanish Group for EUS-Guided TA in the adrenal gland |
| author_facet | A Martin-Cardona G Fernandez-Esparrach J C Subtil J Iglesias-Garcia M Garcia-Guix A Barturen Barroso A Z Gimeno-Garcia J M Esteban A Pardo Balteiro A Velasco-Guardado E Vazquez-Sequeiros C Loras B Martinez-Moreno A Castellot C Huertas M Martinez-Lapiedra A Sanchez-Yague A Teran V J Morales-Alvarado M Betes D de la Iglesia C Sánchez-Montes M D Lozano J Lariño-Noia A Gines C Tebe J B Gornals On belhaf of Spanish Group for EUS-Guided TA in the adrenal gland |
| author_sort | A Martin-Cardona |
| collection | DOAJ |
| description | <h4>Background</h4>There are limited data about the role of endoscopic ultrasound-guided tissue acquisition (EUS-TA), by fine needle aspiration (EUS-FNA) or biopsy (EUS-FNB), in the evaluation of the adrenal glands (AG). The primary aim was to assess the diagnostic yield and safety. The secondary aims were the malignancy predictors, and to create a predictive model of malignancy.<h4>Methods</h4>This was a retrospective nationwide study involving all Spanish hospitals experienced in EUS-TA of AGs. Inclusion period was from April-2003 to April-2016. Inclusion criteria: all consecutive cases that underwent EUS-TA of AGs. EUS and cytopathology findings were evaluated. Statistical analyses: diagnostic accuracy of echoendoscopist's suspicion using cytology by EUS-TA, as gold standard; multivariate logistic regression model to predict tumor malignancy.<h4>Results</h4>A total of 204 EUS-TA of AGs were evaluated. Primary tumor locations were lung70%, others19%, and unknown11%. AG samples were adequate for cytological diagnosis in 91%, and confirmed malignancy in 60%. Diagnostic accuracy of the endosonographer's suspicion was 68%. The most common technique was: a 22-G (65%) and cytological needle (75%) with suction-syringe (66%). No serious adverse events were described. The variables most associated with malignancy were size>30mm (OR2.27; 95%CI, 1.16-4.05), heterogeneous echo-pattern (OR2.11; 95%CI, 1.1-3.9), variegated AG shape (OR2.46; 95%CI, 1-6.24), and endosonographer suspicion (OR17.46; 95%CI, 6.2-58.5). The best variables for a predictive multivariate logistic model of malignancy were age, sex, echo-pattern, and AG-shape.<h4>Conclusions</h4>EUS-TA of the AGs is a safe, minimally invasive procedure, allowing an excellent diagnostic yield. These results suggest the possibility of developing a pre-EUS procedure predictive malignancy model. |
| first_indexed | 2024-12-21T06:01:08Z |
| format | Article |
| id | doaj.art-6a3e182640444980ad1cbb11684cf697 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T06:01:08Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6a3e182640444980ad1cbb11684cf6972022-12-21T19:13:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01146e021665810.1371/journal.pone.0216658EUS-guided tissue acquisition in the study of the adrenal glands: Results of a nationwide multicenter study.A Martin-CardonaG Fernandez-EsparrachJ C SubtilJ Iglesias-GarciaM Garcia-GuixA Barturen BarrosoA Z Gimeno-GarciaJ M EstebanA Pardo BalteiroA Velasco-GuardadoE Vazquez-SequeirosC LorasB Martinez-MorenoA CastellotC HuertasM Martinez-LapiedraA Sanchez-YagueA TeranV J Morales-AlvaradoM BetesD de la IglesiaC Sánchez-MontesM D LozanoJ Lariño-NoiaA GinesC TebeJ B GornalsOn belhaf of Spanish Group for EUS-Guided TA in the adrenal gland<h4>Background</h4>There are limited data about the role of endoscopic ultrasound-guided tissue acquisition (EUS-TA), by fine needle aspiration (EUS-FNA) or biopsy (EUS-FNB), in the evaluation of the adrenal glands (AG). The primary aim was to assess the diagnostic yield and safety. The secondary aims were the malignancy predictors, and to create a predictive model of malignancy.<h4>Methods</h4>This was a retrospective nationwide study involving all Spanish hospitals experienced in EUS-TA of AGs. Inclusion period was from April-2003 to April-2016. Inclusion criteria: all consecutive cases that underwent EUS-TA of AGs. EUS and cytopathology findings were evaluated. Statistical analyses: diagnostic accuracy of echoendoscopist's suspicion using cytology by EUS-TA, as gold standard; multivariate logistic regression model to predict tumor malignancy.<h4>Results</h4>A total of 204 EUS-TA of AGs were evaluated. Primary tumor locations were lung70%, others19%, and unknown11%. AG samples were adequate for cytological diagnosis in 91%, and confirmed malignancy in 60%. Diagnostic accuracy of the endosonographer's suspicion was 68%. The most common technique was: a 22-G (65%) and cytological needle (75%) with suction-syringe (66%). No serious adverse events were described. The variables most associated with malignancy were size>30mm (OR2.27; 95%CI, 1.16-4.05), heterogeneous echo-pattern (OR2.11; 95%CI, 1.1-3.9), variegated AG shape (OR2.46; 95%CI, 1-6.24), and endosonographer suspicion (OR17.46; 95%CI, 6.2-58.5). The best variables for a predictive multivariate logistic model of malignancy were age, sex, echo-pattern, and AG-shape.<h4>Conclusions</h4>EUS-TA of the AGs is a safe, minimally invasive procedure, allowing an excellent diagnostic yield. These results suggest the possibility of developing a pre-EUS procedure predictive malignancy model.https://doi.org/10.1371/journal.pone.0216658 |
| spellingShingle | A Martin-Cardona G Fernandez-Esparrach J C Subtil J Iglesias-Garcia M Garcia-Guix A Barturen Barroso A Z Gimeno-Garcia J M Esteban A Pardo Balteiro A Velasco-Guardado E Vazquez-Sequeiros C Loras B Martinez-Moreno A Castellot C Huertas M Martinez-Lapiedra A Sanchez-Yague A Teran V J Morales-Alvarado M Betes D de la Iglesia C Sánchez-Montes M D Lozano J Lariño-Noia A Gines C Tebe J B Gornals On belhaf of Spanish Group for EUS-Guided TA in the adrenal gland EUS-guided tissue acquisition in the study of the adrenal glands: Results of a nationwide multicenter study. PLoS ONE |
| title | EUS-guided tissue acquisition in the study of the adrenal glands: Results of a nationwide multicenter study. |
| title_full | EUS-guided tissue acquisition in the study of the adrenal glands: Results of a nationwide multicenter study. |
| title_fullStr | EUS-guided tissue acquisition in the study of the adrenal glands: Results of a nationwide multicenter study. |
| title_full_unstemmed | EUS-guided tissue acquisition in the study of the adrenal glands: Results of a nationwide multicenter study. |
| title_short | EUS-guided tissue acquisition in the study of the adrenal glands: Results of a nationwide multicenter study. |
| title_sort | eus guided tissue acquisition in the study of the adrenal glands results of a nationwide multicenter study |
| url | https://doi.org/10.1371/journal.pone.0216658 |
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