Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection
For the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, clinical manifestations are broad and highly heterogeneous for both sexes. We aimed to determine how biological sex and age impact immune gene expression, particularly influencing the humoral neutralizing antibody (NAb)...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023002529 |
| _version_ | 1828043664281042944 |
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| author | Vicky Margarita Montaño Mendoza Yorjagis Andres Mendez Cortina Ana Lucía Rodríguez-Perea Geysson Javier Fernandez María Teresa Rugeles Paula A. Velilla Hernandez Walter D. Cardona Maya |
| author_facet | Vicky Margarita Montaño Mendoza Yorjagis Andres Mendez Cortina Ana Lucía Rodríguez-Perea Geysson Javier Fernandez María Teresa Rugeles Paula A. Velilla Hernandez Walter D. Cardona Maya |
| author_sort | Vicky Margarita Montaño Mendoza |
| collection | DOAJ |
| description | For the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, clinical manifestations are broad and highly heterogeneous for both sexes. We aimed to determine how biological sex and age impact immune gene expression, particularly influencing the humoral neutralizing antibody (NAb) response and the cytokine production in coronavirus disease 2019 (COVID-19) subjects. The immune gene expression, according to biological sex and age, was assessed using the genome wide expression profile of blood proteins from healthy individuals using the Genotype Tissue Expression (GTEx) database. Moreover, anti-SARS-CoV-2 neutralizing antibody titers and cytokine levels were determined in blood samples from 141 COVID-19 individuals from Medellín, Colombia. Among subjects with COVID-19, males had statistically significantly higher median NAb titers and serum concentrations of interleukin-6 and CC chemokine ligand 3 than females. Overall, our findings point out a more robust innate immune response in women that could help recognize and restrain the virus faster than in men. |
| first_indexed | 2024-04-10T17:45:25Z |
| format | Article |
| id | doaj.art-6a3ee1840352483383e091c784779bac |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-10T17:45:25Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-6a3ee1840352483383e091c784779bac2023-02-03T05:00:18ZengElsevierHeliyon2405-84402023-01-0191e13045Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infectionVicky Margarita Montaño Mendoza0Yorjagis Andres Mendez Cortina1Ana Lucía Rodríguez-Perea2Geysson Javier Fernandez3María Teresa Rugeles4Paula A. Velilla Hernandez5Walter D. Cardona Maya6Grupo Reproducción, Facultad de Medicina, Universidad de Antioquia - UdeA, Medellín, ColombiaGrupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia - UdeA, Medellín, ColombiaGrupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia - UdeA, Medellín, ColombiaGrupo Biología y Control de Enfermedades Infecciosas BCEI, Universidad de Antioquia - UdeA, Medellín, ColombiaGrupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia - UdeA, Medellín, ColombiaGrupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia - UdeA, Medellín, ColombiaGrupo Reproducción, Facultad de Medicina, Universidad de Antioquia - UdeA, Medellín, Colombia; Corresponding author.For the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, clinical manifestations are broad and highly heterogeneous for both sexes. We aimed to determine how biological sex and age impact immune gene expression, particularly influencing the humoral neutralizing antibody (NAb) response and the cytokine production in coronavirus disease 2019 (COVID-19) subjects. The immune gene expression, according to biological sex and age, was assessed using the genome wide expression profile of blood proteins from healthy individuals using the Genotype Tissue Expression (GTEx) database. Moreover, anti-SARS-CoV-2 neutralizing antibody titers and cytokine levels were determined in blood samples from 141 COVID-19 individuals from Medellín, Colombia. Among subjects with COVID-19, males had statistically significantly higher median NAb titers and serum concentrations of interleukin-6 and CC chemokine ligand 3 than females. Overall, our findings point out a more robust innate immune response in women that could help recognize and restrain the virus faster than in men.http://www.sciencedirect.com/science/article/pii/S2405844023002529GeneSARS-CoV-2ImmunologyMaleVirusSex |
| spellingShingle | Vicky Margarita Montaño Mendoza Yorjagis Andres Mendez Cortina Ana Lucía Rodríguez-Perea Geysson Javier Fernandez María Teresa Rugeles Paula A. Velilla Hernandez Walter D. Cardona Maya Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection Heliyon Gene SARS-CoV-2 Immunology Male Virus Sex |
| title | Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection |
| title_full | Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection |
| title_fullStr | Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection |
| title_full_unstemmed | Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection |
| title_short | Biological sex and age-related differences shape the antiviral response to SARS-CoV-2 infection |
| title_sort | biological sex and age related differences shape the antiviral response to sars cov 2 infection |
| topic | Gene SARS-CoV-2 Immunology Male Virus Sex |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023002529 |
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