Unravelling Insights into the Evolution and Management of SARS-CoV-2
Worldwide, the COVID-19 pandemic, caused by the brand-new coronavirus SARS-CoV-2, has claimed a sizable number of lives. The virus’ rapid spread and impact on every facet of human existence necessitate a continuous and dynamic examination of its biology and management. Despite this urgency, COVID-19...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | BioMedInformatics |
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| Online Access: | https://www.mdpi.com/2673-7426/4/1/22 |
| _version_ | 1797241935045328896 |
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| author | Aganze Gloire-Aimé Mushebenge Samuel Chima Ugbaja Nonkululeko Avril Mbatha Rene B. Khan Hezekiel M. Kumalo |
| author_facet | Aganze Gloire-Aimé Mushebenge Samuel Chima Ugbaja Nonkululeko Avril Mbatha Rene B. Khan Hezekiel M. Kumalo |
| author_sort | Aganze Gloire-Aimé Mushebenge |
| collection | DOAJ |
| description | Worldwide, the COVID-19 pandemic, caused by the brand-new coronavirus SARS-CoV-2, has claimed a sizable number of lives. The virus’ rapid spread and impact on every facet of human existence necessitate a continuous and dynamic examination of its biology and management. Despite this urgency, COVID-19 does not currently have any particular antiviral treatments. As a result, scientists are concentrating on repurposing existing antiviral medications or creating brand-new ones. This comprehensive review seeks to provide an in-depth exploration of our current understanding of SARS-CoV-2, starting with an analysis of its prevalence, pathology, and evolutionary trends. In doing so, the review aims to clarify the complex network of factors that have contributed to the varying case fatality rates observed in different geographic areas. In this work, we explore the complex world of SARS-CoV-2 mutations and their implications for vaccine efficacy and therapeutic interventions. The dynamic viral landscape of the pandemic poses a significant challenge, leading scientists to investigate the genetic foundations of the virus and the mechanisms underlying these genetic alterations. Numerous hypotheses have been proposed as the pandemic has developed, covering various subjects like the selection pressures driving mutation, the possibility of vaccine escape, and the consequences for clinical therapy. Furthermore, this review will shed light on current clinical trials investigating novel medicines and vaccine development, including the promising field of drug repurposing, providing a window into the changing field of treatment approaches. This study provides a comprehensive understanding of the virus by compiling the huge and evolving body of knowledge on SARS-CoV-2, highlighting its complexities and implications for public health, and igniting additional investigation into the control of this unprecedented global health disaster. |
| first_indexed | 2024-04-24T18:31:13Z |
| format | Article |
| id | doaj.art-6a3f19526fb0484aa35d28d1b329ff3e |
| institution | Directory Open Access Journal |
| issn | 2673-7426 |
| language | English |
| last_indexed | 2024-04-24T18:31:13Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | BioMedInformatics |
| spelling | doaj.art-6a3f19526fb0484aa35d28d1b329ff3e2024-03-27T13:27:30ZengMDPI AGBioMedInformatics2673-74262024-02-014138540910.3390/biomedinformatics4010022Unravelling Insights into the Evolution and Management of SARS-CoV-2Aganze Gloire-Aimé Mushebenge0Samuel Chima Ugbaja1Nonkululeko Avril Mbatha2Rene B. Khan3Hezekiel M. Kumalo4Discipline of Pharmaceutical Sciences, University of KwaZulu-Natal, Westville, Durban 4000, South AfricaDrug Research and Innovation Unit, Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban 4000, South AfricaAfrica Health Research Institute, University of KwaZulu-Natal, Durban 4000, South AfricaDrug Research and Innovation Unit, Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban 4000, South AfricaDrug Research and Innovation Unit, Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Science, University of KwaZulu-Natal, Durban 4000, South AfricaWorldwide, the COVID-19 pandemic, caused by the brand-new coronavirus SARS-CoV-2, has claimed a sizable number of lives. The virus’ rapid spread and impact on every facet of human existence necessitate a continuous and dynamic examination of its biology and management. Despite this urgency, COVID-19 does not currently have any particular antiviral treatments. As a result, scientists are concentrating on repurposing existing antiviral medications or creating brand-new ones. This comprehensive review seeks to provide an in-depth exploration of our current understanding of SARS-CoV-2, starting with an analysis of its prevalence, pathology, and evolutionary trends. In doing so, the review aims to clarify the complex network of factors that have contributed to the varying case fatality rates observed in different geographic areas. In this work, we explore the complex world of SARS-CoV-2 mutations and their implications for vaccine efficacy and therapeutic interventions. The dynamic viral landscape of the pandemic poses a significant challenge, leading scientists to investigate the genetic foundations of the virus and the mechanisms underlying these genetic alterations. Numerous hypotheses have been proposed as the pandemic has developed, covering various subjects like the selection pressures driving mutation, the possibility of vaccine escape, and the consequences for clinical therapy. Furthermore, this review will shed light on current clinical trials investigating novel medicines and vaccine development, including the promising field of drug repurposing, providing a window into the changing field of treatment approaches. This study provides a comprehensive understanding of the virus by compiling the huge and evolving body of knowledge on SARS-CoV-2, highlighting its complexities and implications for public health, and igniting additional investigation into the control of this unprecedented global health disaster.https://www.mdpi.com/2673-7426/4/1/22SARS-CoV-2COVID-19mutationsvaccinestherapeuticsdrug repurposing |
| spellingShingle | Aganze Gloire-Aimé Mushebenge Samuel Chima Ugbaja Nonkululeko Avril Mbatha Rene B. Khan Hezekiel M. Kumalo Unravelling Insights into the Evolution and Management of SARS-CoV-2 BioMedInformatics SARS-CoV-2 COVID-19 mutations vaccines therapeutics drug repurposing |
| title | Unravelling Insights into the Evolution and Management of SARS-CoV-2 |
| title_full | Unravelling Insights into the Evolution and Management of SARS-CoV-2 |
| title_fullStr | Unravelling Insights into the Evolution and Management of SARS-CoV-2 |
| title_full_unstemmed | Unravelling Insights into the Evolution and Management of SARS-CoV-2 |
| title_short | Unravelling Insights into the Evolution and Management of SARS-CoV-2 |
| title_sort | unravelling insights into the evolution and management of sars cov 2 |
| topic | SARS-CoV-2 COVID-19 mutations vaccines therapeutics drug repurposing |
| url | https://www.mdpi.com/2673-7426/4/1/22 |
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