Identification and characterization of a novel enhancer in the HTLV-1 proviral genome
Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic virus with constantly active antisense transcription from the proviral genome. Here, Matsuo et al. perform proviral DNA-capture followed by high-throughput sequencing and identify a yet unknown viral enhancer in the middle of the HTLV-1 pro...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30029-9 |
| _version_ | 1818250646003908608 |
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| author | Misaki Matsuo Takaharu Ueno Kazuaki Monde Kenji Sugata Benjy Jek Yang Tan Akhinur Rahman Paola Miyazato Kyosuke Uchiyama Saiful Islam Hiroo Katsuya Shinsuke Nakajima Masahito Tokunaga Kisato Nosaka Hiroyuki Hata Atae Utsunomiya Jun-ichi Fujisawa Yorifumi Satou |
| author_facet | Misaki Matsuo Takaharu Ueno Kazuaki Monde Kenji Sugata Benjy Jek Yang Tan Akhinur Rahman Paola Miyazato Kyosuke Uchiyama Saiful Islam Hiroo Katsuya Shinsuke Nakajima Masahito Tokunaga Kisato Nosaka Hiroyuki Hata Atae Utsunomiya Jun-ichi Fujisawa Yorifumi Satou |
| author_sort | Misaki Matsuo |
| collection | DOAJ |
| description | Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic virus with constantly active antisense transcription from the proviral genome. Here, Matsuo et al. perform proviral DNA-capture followed by high-throughput sequencing and identify a yet unknown viral enhancer in the middle of the HTLV-1 provirus. |
| first_indexed | 2024-12-12T15:55:41Z |
| format | Article |
| id | doaj.art-6a40a178e7294082b693831a44b1e7a1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-12T15:55:41Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6a40a178e7294082b693831a44b1e7a12022-12-22T00:19:30ZengNature PortfolioNature Communications2041-17232022-05-0113111610.1038/s41467-022-30029-9Identification and characterization of a novel enhancer in the HTLV-1 proviral genomeMisaki Matsuo0Takaharu Ueno1Kazuaki Monde2Kenji Sugata3Benjy Jek Yang Tan4Akhinur Rahman5Paola Miyazato6Kyosuke Uchiyama7Saiful Islam8Hiroo Katsuya9Shinsuke Nakajima10Masahito Tokunaga11Kisato Nosaka12Hiroyuki Hata13Atae Utsunomiya14Jun-ichi Fujisawa15Yorifumi Satou16Division of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto UniversityDepartment of Microbiology, Kansai Medical UniversityDepartment of Microbiology, Faculty of Life Sciences, Kumamoto UniversityDivision of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto UniversityDivision of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto UniversityDivision of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto UniversityDivision of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto UniversityDivision of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto UniversityDivision of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto UniversityDivision of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto UniversityDepartment of Microbiology, Kansai Medical UniversityDepartment of Hematology, Imamura General HospitalDepartment of Hematology, Rheumatology and Infectious Disease, Kumamoto University HospitalDivision of Informative Clinical Sciences, Faculty of Life Sciences, Kumamoto UniversityDepartment of Hematology, Imamura General HospitalDepartment of Microbiology, Kansai Medical UniversityDivision of Genomics and Transcriptomics, Joint Research Center for Human Retrovirus Infection, Kumamoto UniversityHuman T-cell leukemia virus type 1 (HTLV-1) is an oncogenic virus with constantly active antisense transcription from the proviral genome. Here, Matsuo et al. perform proviral DNA-capture followed by high-throughput sequencing and identify a yet unknown viral enhancer in the middle of the HTLV-1 provirus.https://doi.org/10.1038/s41467-022-30029-9 |
| spellingShingle | Misaki Matsuo Takaharu Ueno Kazuaki Monde Kenji Sugata Benjy Jek Yang Tan Akhinur Rahman Paola Miyazato Kyosuke Uchiyama Saiful Islam Hiroo Katsuya Shinsuke Nakajima Masahito Tokunaga Kisato Nosaka Hiroyuki Hata Atae Utsunomiya Jun-ichi Fujisawa Yorifumi Satou Identification and characterization of a novel enhancer in the HTLV-1 proviral genome Nature Communications |
| title | Identification and characterization of a novel enhancer in the HTLV-1 proviral genome |
| title_full | Identification and characterization of a novel enhancer in the HTLV-1 proviral genome |
| title_fullStr | Identification and characterization of a novel enhancer in the HTLV-1 proviral genome |
| title_full_unstemmed | Identification and characterization of a novel enhancer in the HTLV-1 proviral genome |
| title_short | Identification and characterization of a novel enhancer in the HTLV-1 proviral genome |
| title_sort | identification and characterization of a novel enhancer in the htlv 1 proviral genome |
| url | https://doi.org/10.1038/s41467-022-30029-9 |
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