Magnesium sulfate as an adjuvant to anesthesia in patients with arterial hypertension*
There is limited evidence showing that elevated arterial blood pressure in surgical patients may be associated with increased perioperative risk; however, cardiovascular instability frequently occurs during anesthesia. The most commonly used anesthetic agents, both intravenous and inhalation ones, p...
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| Format: | Article |
| Language: | English |
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Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2016-01-01
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| Series: | Acta Clinica Croatica |
| Subjects: | |
| Online Access: | https://hrcak.srce.hr/file/254729 |
| _version_ | 1797207946335092736 |
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| author | Sanja Vicković Miroslava Pjević Arsen Uvelin Dragana Pap Dragan Nikolić Ivica Lalić |
| author_facet | Sanja Vicković Miroslava Pjević Arsen Uvelin Dragana Pap Dragan Nikolić Ivica Lalić |
| author_sort | Sanja Vicković |
| collection | DOAJ |
| description | There is limited evidence showing that elevated arterial blood pressure in surgical patients may be associated with increased perioperative risk; however, cardiovascular instability frequently occurs during anesthesia. The most commonly used anesthetic agents, both intravenous and inhalation ones, produce a decrease in arterial blood pressure. Magnesium, acting as a natural calcium-channel blocker, induces direct and indirect vasodilatation, thus playing a role in the treatment of arterial hypertension. In this research, we assessed the effects of magnesium sulfate on cardiovascular stability in patients undergoing diverse planned surgical procedures (abdominal, orthopedic, urology) under general balanced anesthesia, who were diagnosed with arterial hypertension grade 1 and 2. The research encompassed 100 patients of both sexes, aged from 20 to 65. Immediately before induction of anesthesia with propofol, the patients in the experimental group (50 study subjects) received 30 mg/kg bolus dose and magnesium sulfate infusion at 10 mg/kg/h, whereas the subjects in the control group (50 patients) were administered normal saline. Anesthesia was achieved and maintained with sevoflurane, fentanyl and rocuronium. The hemodynamic variables of mean arterial pressure and heart rate were measured every five minutes, starting immediately before magnesium infusion. Statistical analysis of the categorized values of mean arterial pressure and heart rate revealed a statistically significant between-group difference at 60th and 90th minute of anesthesia. In conclusion, magnesium sulfate as an adjuvant to anesthesia in patients with arterial hypertension reduces hemodynamic changes during anesthesia. |
| first_indexed | 2024-04-24T09:30:59Z |
| format | Article |
| id | doaj.art-6a4162d0e2004b6bb4676a735fa48acd |
| institution | Directory Open Access Journal |
| issn | 0353-9466 1333-9451 |
| language | English |
| last_indexed | 2024-04-24T09:30:59Z |
| publishDate | 2016-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj.art-6a4162d0e2004b6bb4676a735fa48acd2024-04-15T14:00:36ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512016-01-0155.3.49049610.20471/acc.2016.55.03.20Magnesium sulfate as an adjuvant to anesthesia in patients with arterial hypertension*Sanja Vicković0Miroslava Pjević1Arsen Uvelin2Dragana Pap3Dragan Nikolić4Ivica Lalić5Department of Anesthesiology & Intensive Care, Clinical Centre of Vojvodina, Novi Sad, Serbia; University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaDepartment of Anesthesiology & Intensive Care, Clinical Centre of Vojvodina, Novi Sad, Serbia; University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaEmergency Centre, Clinical Centre of Vojvodina, Novi Sad, Serbia; University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaStudents Health Protection Institute, Department of Laboratory Diagnosis, Novi Sad, SerbiaDepartment of Vascular Surgery, Clinical Centre of Vojvodina, Novi Sad, Serbia; University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaDepartment of Orthopedic Surgery, Clinical Centre of Vojvodina, Novi Sad, Serbia; University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaThere is limited evidence showing that elevated arterial blood pressure in surgical patients may be associated with increased perioperative risk; however, cardiovascular instability frequently occurs during anesthesia. The most commonly used anesthetic agents, both intravenous and inhalation ones, produce a decrease in arterial blood pressure. Magnesium, acting as a natural calcium-channel blocker, induces direct and indirect vasodilatation, thus playing a role in the treatment of arterial hypertension. In this research, we assessed the effects of magnesium sulfate on cardiovascular stability in patients undergoing diverse planned surgical procedures (abdominal, orthopedic, urology) under general balanced anesthesia, who were diagnosed with arterial hypertension grade 1 and 2. The research encompassed 100 patients of both sexes, aged from 20 to 65. Immediately before induction of anesthesia with propofol, the patients in the experimental group (50 study subjects) received 30 mg/kg bolus dose and magnesium sulfate infusion at 10 mg/kg/h, whereas the subjects in the control group (50 patients) were administered normal saline. Anesthesia was achieved and maintained with sevoflurane, fentanyl and rocuronium. The hemodynamic variables of mean arterial pressure and heart rate were measured every five minutes, starting immediately before magnesium infusion. Statistical analysis of the categorized values of mean arterial pressure and heart rate revealed a statistically significant between-group difference at 60th and 90th minute of anesthesia. In conclusion, magnesium sulfate as an adjuvant to anesthesia in patients with arterial hypertension reduces hemodynamic changes during anesthesia.https://hrcak.srce.hr/file/254729Magnesium sulfateHypertensionHemodynamicsHeart rateAdjuvants, pharmaceuticalAnesthesia |
| spellingShingle | Sanja Vicković Miroslava Pjević Arsen Uvelin Dragana Pap Dragan Nikolić Ivica Lalić Magnesium sulfate as an adjuvant to anesthesia in patients with arterial hypertension* Acta Clinica Croatica Magnesium sulfate Hypertension Hemodynamics Heart rate Adjuvants, pharmaceutical Anesthesia |
| title | Magnesium sulfate as an adjuvant to anesthesia in patients with arterial hypertension* |
| title_full | Magnesium sulfate as an adjuvant to anesthesia in patients with arterial hypertension* |
| title_fullStr | Magnesium sulfate as an adjuvant to anesthesia in patients with arterial hypertension* |
| title_full_unstemmed | Magnesium sulfate as an adjuvant to anesthesia in patients with arterial hypertension* |
| title_short | Magnesium sulfate as an adjuvant to anesthesia in patients with arterial hypertension* |
| title_sort | magnesium sulfate as an adjuvant to anesthesia in patients with arterial hypertension |
| topic | Magnesium sulfate Hypertension Hemodynamics Heart rate Adjuvants, pharmaceutical Anesthesia |
| url | https://hrcak.srce.hr/file/254729 |
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