Conformational flexibility of a free and TCR-bound pMHC-I protein investigated by long-term molecular dynamics simulations

Conformational flexibility of a free and TCR-bound pMHC-I protein investigated by long-term molecular dynamics simulations

Abstract Background Major histocompatibility complexes (MHCs) play a crucial role in the cell-mediated adaptive immune response as they present antigenic peptides (p) which are recognized by host T cells through a complex formation of the T cell receptor (TCR) with pMHC. In the present study, we rep...

書目詳細資料
Main Authors:	Lisa Tomasiak, Rudolf Karch, Wolfgang Schreiner
格式:	Article
語言:	English
出版:	BMC 2022-07-01
叢編:	BMC Immunology
主題:	Molecular dynamics Major histocompatibility complex T cell receptor
在線閱讀:	https://doi.org/10.1186/s12865-022-00510-7

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