Isolation and identification of Hyoscyamus insanus alkaloids
Hyoscyamus is one of the important genus in Solanaceae which distribution of some of its species is restricted to Iran and some of the neighboring countries. The main medicinal substances in this plant are alkaloids (tropane alkaloids). One of Hyoscyamus species which has not been analysed yet, is H...
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| Format: | Article |
| Language: | English |
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Institue of Medicinal Plants, ACECR
2003-09-01
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| Series: | Journal of Medicinal Plants |
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| Online Access: | http://jmp.ir/article-1-770-en.html |
| _version_ | 1818719765077688320 |
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| author | M Tafaghodi M Hasanzadeh khayat M Rahimizadeh |
| author_facet | M Tafaghodi M Hasanzadeh khayat M Rahimizadeh |
| author_sort | M Tafaghodi |
| collection | DOAJ |
| description | Hyoscyamus is one of the important genus in Solanaceae which distribution of some of its species is restricted to Iran and some of the neighboring countries. The main medicinal substances in this plant are alkaloids (tropane alkaloids). One of Hyoscyamus species which has not been analysed yet, is Hyoscyamus insanus.This plant was collected from southern part of Iran and dried in shaddow and after milling was macerated in 96% ethanol. After maceration, total alkaloids were extracted and using successive column and preparative thin layer chomatography, extract fractionated into three parts. The alkaloids is each fraction was identified using Nuclear Magnetic Resonance (NMR) spectroscopy, Mass Spectrometry (MS) and Ultra Violet (UV) spectrophotometry. These three alkaloids were hyoscyamine (atropine), hyoscine and apoatropin. More than 70% of the total alkaloids was hyoscyamine. Regarding this high percentage of hyoscyamin, this species could potentially be used for large scale production. It should be metioned that this is the first report on alkaloid contents of this plant. |
| first_indexed | 2024-12-17T20:12:08Z |
| format | Article |
| id | doaj.art-6a4496ff315e41a39a6146c6a0ddfd11 |
| institution | Directory Open Access Journal |
| issn | 2717-204X 2717-2058 |
| language | English |
| last_indexed | 2024-12-17T20:12:08Z |
| publishDate | 2003-09-01 |
| publisher | Institue of Medicinal Plants, ACECR |
| record_format | Article |
| series | Journal of Medicinal Plants |
| spelling | doaj.art-6a4496ff315e41a39a6146c6a0ddfd112022-12-21T21:34:13ZengInstitue of Medicinal Plants, ACECRJournal of Medicinal Plants2717-204X2717-20582003-09-01272936Isolation and identification of Hyoscyamus insanus alkaloidsM Tafaghodi0M Hasanzadeh khayat1M Rahimizadeh2 1- School of Pharmacy, and Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. 1- School of Pharmacy, and Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. 2- School of Sciences, Ferdowsi University, Mashhad. Hyoscyamus is one of the important genus in Solanaceae which distribution of some of its species is restricted to Iran and some of the neighboring countries. The main medicinal substances in this plant are alkaloids (tropane alkaloids). One of Hyoscyamus species which has not been analysed yet, is Hyoscyamus insanus.This plant was collected from southern part of Iran and dried in shaddow and after milling was macerated in 96% ethanol. After maceration, total alkaloids were extracted and using successive column and preparative thin layer chomatography, extract fractionated into three parts. The alkaloids is each fraction was identified using Nuclear Magnetic Resonance (NMR) spectroscopy, Mass Spectrometry (MS) and Ultra Violet (UV) spectrophotometry. These three alkaloids were hyoscyamine (atropine), hyoscine and apoatropin. More than 70% of the total alkaloids was hyoscyamine. Regarding this high percentage of hyoscyamin, this species could potentially be used for large scale production. It should be metioned that this is the first report on alkaloid contents of this plant.http://jmp.ir/article-1-770-en.htmlsolanaceaehyoscyamus insanustropane alkaloidshyoscyaminehyoscineapoatropine |
| spellingShingle | M Tafaghodi M Hasanzadeh khayat M Rahimizadeh Isolation and identification of Hyoscyamus insanus alkaloids Journal of Medicinal Plants solanaceae hyoscyamus insanus tropane alkaloids hyoscyamine hyoscine apoatropine |
| title | Isolation and identification of Hyoscyamus insanus alkaloids |
| title_full | Isolation and identification of Hyoscyamus insanus alkaloids |
| title_fullStr | Isolation and identification of Hyoscyamus insanus alkaloids |
| title_full_unstemmed | Isolation and identification of Hyoscyamus insanus alkaloids |
| title_short | Isolation and identification of Hyoscyamus insanus alkaloids |
| title_sort | isolation and identification of hyoscyamus insanus alkaloids |
| topic | solanaceae hyoscyamus insanus tropane alkaloids hyoscyamine hyoscine apoatropine |
| url | http://jmp.ir/article-1-770-en.html |
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