Evaluation of simvastatin in the process of fracture healing in tibiae of rats
OBJECTIVE: Evaluate the effects of simvastatin in the process of fracture healing in rat tibia. METHODS: Thirty-six rats were subjected to diaphyseal fracture of the leg bones and divided in the statin group (GE) and control group (GC), being subdivided into three subgroups according to days pos...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2013-04-01
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| Series: | Revista Brasileira de Ortopedia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162013000200191 |
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| author | José Wanderley Vasconcelos Leopoldina Milanez da Silva Leite Gerusa de Arruda Vasconcelos Igor Marcelo Souto Maior Araujo Letácio Santos Garcia Ferro |
| author_facet | José Wanderley Vasconcelos Leopoldina Milanez da Silva Leite Gerusa de Arruda Vasconcelos Igor Marcelo Souto Maior Araujo Letácio Santos Garcia Ferro |
| author_sort | José Wanderley Vasconcelos |
| collection | DOAJ |
| description | OBJECTIVE: Evaluate the effects of simvastatin in the process of fracture healing in rat tibia. METHODS: Thirty-six rats were subjected to diaphyseal fracture of the leg bones and divided in the statin group (GE) and control group (GC), being subdivided into three subgroups according to days post-fracture (7th, 14th and 28th day) to assess bone healing. In GE was administered by gavage a solution of simvastatin to the sacrifice. In the control group was administered saline by the same route of SG. Immobilization was not used. After the sacrifice was made to limb amputation in the distal femur and conducted the clinical, radiological and histological analysis. Clinical evaluation was made as to the mobility of the fracture. Then the samples were radiographed and evaluated for callus diameter. Histological examination was performed with cuts of 5 micrometers and stained with hematoxylin-eosin, Masson's trichrome and Alcian blue pH 2.5. The level of significance to exclude the null hypothesis was 5%. RESULTS: All GE animals showed greater stability of the fracture and higher callus area. There were no significant changes in the histological study. CONCLUSION: Simvastatin accelerates the consolidation process by increasing the callus, but does not alter the histology of the newly formed bone. |
| first_indexed | 2024-03-08T07:10:38Z |
| format | Article |
| id | doaj.art-6a44fe796b0a4cdf83e3547eee806ee9 |
| institution | Directory Open Access Journal |
| issn | 0102-3616 1982-4378 |
| language | English |
| last_indexed | 2025-03-22T04:06:57Z |
| publishDate | 2013-04-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Revista Brasileira de Ortopedia |
| spelling | doaj.art-6a44fe796b0a4cdf83e3547eee806ee92024-04-28T09:06:16ZengThieme Revinter Publicações Ltda.Revista Brasileira de Ortopedia0102-36161982-43782013-04-01482191195Evaluation of simvastatin in the process of fracture healing in tibiae of ratsJosé Wanderley VasconcelosLeopoldina Milanez da Silva LeiteGerusa de Arruda VasconcelosIgor Marcelo Souto Maior AraujoLetácio Santos Garcia FerroOBJECTIVE: Evaluate the effects of simvastatin in the process of fracture healing in rat tibia. METHODS: Thirty-six rats were subjected to diaphyseal fracture of the leg bones and divided in the statin group (GE) and control group (GC), being subdivided into three subgroups according to days post-fracture (7th, 14th and 28th day) to assess bone healing. In GE was administered by gavage a solution of simvastatin to the sacrifice. In the control group was administered saline by the same route of SG. Immobilization was not used. After the sacrifice was made to limb amputation in the distal femur and conducted the clinical, radiological and histological analysis. Clinical evaluation was made as to the mobility of the fracture. Then the samples were radiographed and evaluated for callus diameter. Histological examination was performed with cuts of 5 micrometers and stained with hematoxylin-eosin, Masson's trichrome and Alcian blue pH 2.5. The level of significance to exclude the null hypothesis was 5%. RESULTS: All GE animals showed greater stability of the fracture and higher callus area. There were no significant changes in the histological study. CONCLUSION: Simvastatin accelerates the consolidation process by increasing the callus, but does not alter the histology of the newly formed bone.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162013000200191SinvastatinaFraturas da tíbiaRatosConsolidação da fraturaSimvastatinTibial fracturesRatsFracture healing |
| spellingShingle | José Wanderley Vasconcelos Leopoldina Milanez da Silva Leite Gerusa de Arruda Vasconcelos Igor Marcelo Souto Maior Araujo Letácio Santos Garcia Ferro Evaluation of simvastatin in the process of fracture healing in tibiae of rats Revista Brasileira de Ortopedia Sinvastatina Fraturas da tíbia Ratos Consolidação da fratura Simvastatin Tibial fractures Rats Fracture healing |
| title | Evaluation of simvastatin in the process of fracture healing in tibiae of rats |
| title_full | Evaluation of simvastatin in the process of fracture healing in tibiae of rats |
| title_fullStr | Evaluation of simvastatin in the process of fracture healing in tibiae of rats |
| title_full_unstemmed | Evaluation of simvastatin in the process of fracture healing in tibiae of rats |
| title_short | Evaluation of simvastatin in the process of fracture healing in tibiae of rats |
| title_sort | evaluation of simvastatin in the process of fracture healing in tibiae of rats |
| topic | Sinvastatina Fraturas da tíbia Ratos Consolidação da fratura Simvastatin Tibial fractures Rats Fracture healing |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162013000200191 |
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