Cross-Sectional Evaluation of Kidney Function in Hospitalized Patients: Estimated GFR Versus Renal Scintigraphy
Background/Aims: Accurate staging of chronic kidney disease (CKD) is very important. We tried to identify difference in GFR evaluation between CKD-EPI and Gates method with renal scintigraphy and which variables are associated with these differences. Methods: We retrospectively reviewed the records...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2014-12-01
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| Series: | Kidney & Blood Pressure Research |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/355813 |
| _version_ | 1818246358560145408 |
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| author | Domenico Santoro Zaira Zappulla Angela Alibrandi Milos Tomasello Andulajevic Maria Licari Sergio Baldari Michele Buemi Valeria Cernaro Alfredo Campennὶ |
| author_facet | Domenico Santoro Zaira Zappulla Angela Alibrandi Milos Tomasello Andulajevic Maria Licari Sergio Baldari Michele Buemi Valeria Cernaro Alfredo Campennὶ |
| author_sort | Domenico Santoro |
| collection | DOAJ |
| description | Background/Aims: Accurate staging of chronic kidney disease (CKD) is very important. We tried to identify difference in GFR evaluation between CKD-EPI and Gates method with renal scintigraphy and which variables are associated with these differences. Methods: We retrospectively reviewed the records of 341 patients who underwent dynamic renal scintigraphy in the last 5 years. Patients were categorized according to KDIGO staging I to V, using the eGFR calculated with the CKD-EPI equation. Secondarily, we stratified patients according to treatment with renin-angiotensin system (RAS) inhibitors. Results: Gates method tends to underestimate GFR especially in CKD stage I (mean -22.2 ml/min) and II (mean -12.5 ml/min). The division in quartiles of ages showed an underestimation of GFR only in the first quartile of age (Conclusion: The assessment of GFR by the Gates method must be carefully considered in the early stages of CKD, especially in younger patients. Moreover, the difference is more pronounced in patients treated with RAS inhibitors. Longitudinal studies will prove which method better predicts cardiovascular or renal events. |
| first_indexed | 2024-12-12T14:47:33Z |
| format | Article |
| id | doaj.art-6a456230557445a792bc8b05398e0491 |
| institution | Directory Open Access Journal |
| issn | 1420-4096 1423-0143 |
| language | English |
| last_indexed | 2024-12-12T14:47:33Z |
| publishDate | 2014-12-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney & Blood Pressure Research |
| spelling | doaj.art-6a456230557445a792bc8b05398e04912022-12-22T00:21:05ZengKarger PublishersKidney & Blood Pressure Research1420-40961423-01432014-12-0139666867610.1159/000355813355813Cross-Sectional Evaluation of Kidney Function in Hospitalized Patients: Estimated GFR Versus Renal ScintigraphyDomenico SantoroZaira ZappullaAngela AlibrandiMilos Tomasello AndulajevicMaria LicariSergio BaldariMichele BuemiValeria CernaroAlfredo CampennὶBackground/Aims: Accurate staging of chronic kidney disease (CKD) is very important. We tried to identify difference in GFR evaluation between CKD-EPI and Gates method with renal scintigraphy and which variables are associated with these differences. Methods: We retrospectively reviewed the records of 341 patients who underwent dynamic renal scintigraphy in the last 5 years. Patients were categorized according to KDIGO staging I to V, using the eGFR calculated with the CKD-EPI equation. Secondarily, we stratified patients according to treatment with renin-angiotensin system (RAS) inhibitors. Results: Gates method tends to underestimate GFR especially in CKD stage I (mean -22.2 ml/min) and II (mean -12.5 ml/min). The division in quartiles of ages showed an underestimation of GFR only in the first quartile of age (Conclusion: The assessment of GFR by the Gates method must be carefully considered in the early stages of CKD, especially in younger patients. Moreover, the difference is more pronounced in patients treated with RAS inhibitors. Longitudinal studies will prove which method better predicts cardiovascular or renal events.http://www.karger.com/Article/FullText/355813RAS inhibitorseGFRCKD-EPIMDRDRenal Scintigraphy |
| spellingShingle | Domenico Santoro Zaira Zappulla Angela Alibrandi Milos Tomasello Andulajevic Maria Licari Sergio Baldari Michele Buemi Valeria Cernaro Alfredo Campennὶ Cross-Sectional Evaluation of Kidney Function in Hospitalized Patients: Estimated GFR Versus Renal Scintigraphy Kidney & Blood Pressure Research RAS inhibitors eGFR CKD-EPI MDRD Renal Scintigraphy |
| title | Cross-Sectional Evaluation of Kidney Function in Hospitalized Patients: Estimated GFR Versus Renal Scintigraphy |
| title_full | Cross-Sectional Evaluation of Kidney Function in Hospitalized Patients: Estimated GFR Versus Renal Scintigraphy |
| title_fullStr | Cross-Sectional Evaluation of Kidney Function in Hospitalized Patients: Estimated GFR Versus Renal Scintigraphy |
| title_full_unstemmed | Cross-Sectional Evaluation of Kidney Function in Hospitalized Patients: Estimated GFR Versus Renal Scintigraphy |
| title_short | Cross-Sectional Evaluation of Kidney Function in Hospitalized Patients: Estimated GFR Versus Renal Scintigraphy |
| title_sort | cross sectional evaluation of kidney function in hospitalized patients estimated gfr versus renal scintigraphy |
| topic | RAS inhibitors eGFR CKD-EPI MDRD Renal Scintigraphy |
| url | http://www.karger.com/Article/FullText/355813 |
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