A Web-based Simulator for Sample Size and Power Estimation in Animal Carcinogenicity Studies
A Web-based statistical tool for sample size and power estimation in animal carcinogenicity studies is presented in this paper. It can be used to provide a design with sufficient power for detecting a dose-related trend in the occurrence of a tumor of interest when competing risks are present. The t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Foundation for Open Access Statistics
2002-12-01
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| Series: | Journal of Statistical Software |
| Online Access: | http://www.jstatsoft.org/index.php/jss/article/view/2298 |
| _version_ | 1819207801708216320 |
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| author | Hojin Moon J. Jack Lee Hongshik Ahn Rumiana G. Nikolova |
| author_facet | Hojin Moon J. Jack Lee Hongshik Ahn Rumiana G. Nikolova |
| author_sort | Hojin Moon |
| collection | DOAJ |
| description | A Web-based statistical tool for sample size and power estimation in animal carcinogenicity studies is presented in this paper. It can be used to provide a design with sufficient power for detecting a dose-related trend in the occurrence of a tumor of interest when competing risks are present. The tumors of interest typically are occult tumors for which the time to tumor onset is not directly observable. It is applicable to rodent tumorigenicity assays that have either a single terminal sacrifice or multiple (interval) sacrifices. The design is achieved by varying sample size per group, number of sacrifices, number of sacrificed animals at each interval, if any, and scheduled time points for sacrifice. Monte Carlo simulation is carried out in this tool to simulate experiments of rodent bioassays because no closed-form solution is available. It takes design parameters for sample size and power estimation as inputs through the World Wide Web. The core program is written in C and executed in the background. It communicates with the Web front end via a Component Object Model interface passing an Extensible Markup Language string. The proposed statistical tool is illustrated with an animal study in lung cancer prevention research. |
| first_indexed | 2024-12-23T05:29:16Z |
| format | Article |
| id | doaj.art-6a457a44e1cd46d1844e9395a4676352 |
| institution | Directory Open Access Journal |
| issn | 1548-7660 |
| language | English |
| last_indexed | 2024-12-23T05:29:16Z |
| publishDate | 2002-12-01 |
| publisher | Foundation for Open Access Statistics |
| record_format | Article |
| series | Journal of Statistical Software |
| spelling | doaj.art-6a457a44e1cd46d1844e9395a46763522022-12-21T17:58:31ZengFoundation for Open Access StatisticsJournal of Statistical Software1548-76602002-12-017113610.18637/jss.v007.i13902A Web-based Simulator for Sample Size and Power Estimation in Animal Carcinogenicity StudiesHojin MoonJ. Jack LeeHongshik AhnRumiana G. NikolovaA Web-based statistical tool for sample size and power estimation in animal carcinogenicity studies is presented in this paper. It can be used to provide a design with sufficient power for detecting a dose-related trend in the occurrence of a tumor of interest when competing risks are present. The tumors of interest typically are occult tumors for which the time to tumor onset is not directly observable. It is applicable to rodent tumorigenicity assays that have either a single terminal sacrifice or multiple (interval) sacrifices. The design is achieved by varying sample size per group, number of sacrifices, number of sacrificed animals at each interval, if any, and scheduled time points for sacrifice. Monte Carlo simulation is carried out in this tool to simulate experiments of rodent bioassays because no closed-form solution is available. It takes design parameters for sample size and power estimation as inputs through the World Wide Web. The core program is written in C and executed in the background. It communicates with the Web front end via a Component Object Model interface passing an Extensible Markup Language string. The proposed statistical tool is illustrated with an animal study in lung cancer prevention research.http://www.jstatsoft.org/index.php/jss/article/view/2298 |
| spellingShingle | Hojin Moon J. Jack Lee Hongshik Ahn Rumiana G. Nikolova A Web-based Simulator for Sample Size and Power Estimation in Animal Carcinogenicity Studies Journal of Statistical Software |
| title | A Web-based Simulator for Sample Size and Power Estimation in Animal Carcinogenicity Studies |
| title_full | A Web-based Simulator for Sample Size and Power Estimation in Animal Carcinogenicity Studies |
| title_fullStr | A Web-based Simulator for Sample Size and Power Estimation in Animal Carcinogenicity Studies |
| title_full_unstemmed | A Web-based Simulator for Sample Size and Power Estimation in Animal Carcinogenicity Studies |
| title_short | A Web-based Simulator for Sample Size and Power Estimation in Animal Carcinogenicity Studies |
| title_sort | web based simulator for sample size and power estimation in animal carcinogenicity studies |
| url | http://www.jstatsoft.org/index.php/jss/article/view/2298 |
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