Regulatory Role of Non-Coding RNAs on Immune Responses During Sepsis
Sepsis is resulted from a systemic inflammatory response to bacterial, viral, or fungal agents. The induced inflammatory response by these microorganisms can lead to multiple organ system failure with devastating consequences. Recent studies have shown altered expressions of several non-coding RNAs...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.798713/full |
| _version_ | 1818401406086807552 |
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| author | Soudeh Ghafouri-Fard Tayyebeh Khoshbakht Bashdar Mahmud Hussen Bashdar Mahmud Hussen Mohammad Taheri Normohammad Arefian |
| author_facet | Soudeh Ghafouri-Fard Tayyebeh Khoshbakht Bashdar Mahmud Hussen Bashdar Mahmud Hussen Mohammad Taheri Normohammad Arefian |
| author_sort | Soudeh Ghafouri-Fard |
| collection | DOAJ |
| description | Sepsis is resulted from a systemic inflammatory response to bacterial, viral, or fungal agents. The induced inflammatory response by these microorganisms can lead to multiple organ system failure with devastating consequences. Recent studies have shown altered expressions of several non-coding RNAs such as long non-coding RNAs (lncRNAs), microRNAs (miRNAs) and circular RNAs (circRNAs) during sepsis. These transcripts have also been found to participate in the pathogenesis of multiple organ system failure through different mechanisms. NEAT1, MALAT1, THRIL, XIST, MIAT and TUG1 are among lncRNAs that participate in the pathoetiology of sepsis-related complications. miR-21, miR-155, miR-15a-5p, miR-494-3p, miR-218, miR-122, miR-208a-5p, miR-328 and miR-218 are examples of miRNAs participating in these complications. Finally, tens of circRNAs such as circC3P1, hsa_circRNA_104484, hsa_circRNA_104670 and circVMA21 and circ-PRKCI have been found to affect pathogenesis of sepsis. In the current review, we describe the role of these three classes of noncoding RNAs in the pathoetiology of sepsis-related complications. |
| first_indexed | 2024-12-14T07:51:57Z |
| format | Article |
| id | doaj.art-6a4bb35d896a41f9a743e1c3d6bac59a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-14T07:51:57Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-6a4bb35d896a41f9a743e1c3d6bac59a2022-12-21T23:10:41ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-12-011210.3389/fimmu.2021.798713798713Regulatory Role of Non-Coding RNAs on Immune Responses During SepsisSoudeh Ghafouri-Fard0Tayyebeh Khoshbakht1Bashdar Mahmud Hussen2Bashdar Mahmud Hussen3Mohammad Taheri4Normohammad Arefian5Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranPhytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, IraqCenter of Research and Strategic Studies, Lebanese French University, Erbil, IraqInstitute of Human Genetics, Jena University Hospital, Jena, GermanySkull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranSepsis is resulted from a systemic inflammatory response to bacterial, viral, or fungal agents. The induced inflammatory response by these microorganisms can lead to multiple organ system failure with devastating consequences. Recent studies have shown altered expressions of several non-coding RNAs such as long non-coding RNAs (lncRNAs), microRNAs (miRNAs) and circular RNAs (circRNAs) during sepsis. These transcripts have also been found to participate in the pathogenesis of multiple organ system failure through different mechanisms. NEAT1, MALAT1, THRIL, XIST, MIAT and TUG1 are among lncRNAs that participate in the pathoetiology of sepsis-related complications. miR-21, miR-155, miR-15a-5p, miR-494-3p, miR-218, miR-122, miR-208a-5p, miR-328 and miR-218 are examples of miRNAs participating in these complications. Finally, tens of circRNAs such as circC3P1, hsa_circRNA_104484, hsa_circRNA_104670 and circVMA21 and circ-PRKCI have been found to affect pathogenesis of sepsis. In the current review, we describe the role of these three classes of noncoding RNAs in the pathoetiology of sepsis-related complications.https://www.frontiersin.org/articles/10.3389/fimmu.2021.798713/fulllncRNAmiRNAsepsisexpressionbiomarker |
| spellingShingle | Soudeh Ghafouri-Fard Tayyebeh Khoshbakht Bashdar Mahmud Hussen Bashdar Mahmud Hussen Mohammad Taheri Normohammad Arefian Regulatory Role of Non-Coding RNAs on Immune Responses During Sepsis Frontiers in Immunology lncRNA miRNA sepsis expression biomarker |
| title | Regulatory Role of Non-Coding RNAs on Immune Responses During Sepsis |
| title_full | Regulatory Role of Non-Coding RNAs on Immune Responses During Sepsis |
| title_fullStr | Regulatory Role of Non-Coding RNAs on Immune Responses During Sepsis |
| title_full_unstemmed | Regulatory Role of Non-Coding RNAs on Immune Responses During Sepsis |
| title_short | Regulatory Role of Non-Coding RNAs on Immune Responses During Sepsis |
| title_sort | regulatory role of non coding rnas on immune responses during sepsis |
| topic | lncRNA miRNA sepsis expression biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.798713/full |
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