Novel Anti-Inflammatory Approaches to COPD
Mario Cazzola,1 Nicola A Hanania,2 Clive P Page,3 Maria Gabriella Matera4 1Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome, Italy; 2Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX, USA; 3Sackler Institute of Pulmonary Pharmacology,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-06-01
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| Series: | International Journal of COPD |
| Subjects: | |
| Online Access: | https://www.dovepress.com/novel-anti-inflammatory-approaches-to-copd-peer-reviewed-fulltext-article-COPD |
| _version_ | 1797789432570445824 |
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| author | Cazzola M Hanania NA Page CP Matera MG |
| author_facet | Cazzola M Hanania NA Page CP Matera MG |
| author_sort | Cazzola M |
| collection | DOAJ |
| description | Mario Cazzola,1 Nicola A Hanania,2 Clive P Page,3 Maria Gabriella Matera4 1Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome, Italy; 2Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX, USA; 3Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King’s College London, London, UK; 4Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Naples, ItalyCorrespondence: Mario Cazzola, Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome, Italy, Email mario.cazzola@uniroma2.itAbstract: Airway inflammation, driven by different types of inflammatory cells and mediators, plays a fundamental role in COPD and its progression. Neutrophils, eosinophils, macrophages, and CD4+ and CD8+ T lymphocytes are key players in this process, although the extent of their participation varies according to the patient’s endotype. Anti-inflammatory medications may modify the natural history and progression of COPD. However, since airway inflammation in COPD is relatively resistant to corticosteroid therapy, innovative pharmacological anti-inflammatory approaches are required. The heterogeneity of inflammatory cells and mediators in annethe different COPD endo-phenotypes requires the development of specific pharmacologic agents. Indeed, over the past two decades, several mechanisms that influence the influx and/or activity of inflammatory cells in the airways and lung parenchyma have been identified. Several of these molecules have been tested in vitro models and in vivo in laboratory animals, but only a few have been studied in humans. Although early studies have not been encouraging, useful information emerged suggesting that some of these agents may need to be further tested in specific subgroups of patients, hopefully leading to a more personalized approach to treating COPD.Keywords: anti-inflammatory drugs, COPD, inflammation, treatment |
| first_indexed | 2024-03-13T01:50:33Z |
| format | Article |
| id | doaj.art-6a4f3d4edef74c4a8d151afa59e38f38 |
| institution | Directory Open Access Journal |
| issn | 1178-2005 |
| language | English |
| last_indexed | 2024-03-13T01:50:33Z |
| publishDate | 2023-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-6a4f3d4edef74c4a8d151afa59e38f382023-07-02T19:49:16ZengDove Medical PressInternational Journal of COPD1178-20052023-06-01Volume 181333135284803Novel Anti-Inflammatory Approaches to COPDCazzola MHanania NAPage CPMatera MGMario Cazzola,1 Nicola A Hanania,2 Clive P Page,3 Maria Gabriella Matera4 1Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome, Italy; 2Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX, USA; 3Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King’s College London, London, UK; 4Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Naples, ItalyCorrespondence: Mario Cazzola, Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome, Italy, Email mario.cazzola@uniroma2.itAbstract: Airway inflammation, driven by different types of inflammatory cells and mediators, plays a fundamental role in COPD and its progression. Neutrophils, eosinophils, macrophages, and CD4+ and CD8+ T lymphocytes are key players in this process, although the extent of their participation varies according to the patient’s endotype. Anti-inflammatory medications may modify the natural history and progression of COPD. However, since airway inflammation in COPD is relatively resistant to corticosteroid therapy, innovative pharmacological anti-inflammatory approaches are required. The heterogeneity of inflammatory cells and mediators in annethe different COPD endo-phenotypes requires the development of specific pharmacologic agents. Indeed, over the past two decades, several mechanisms that influence the influx and/or activity of inflammatory cells in the airways and lung parenchyma have been identified. Several of these molecules have been tested in vitro models and in vivo in laboratory animals, but only a few have been studied in humans. Although early studies have not been encouraging, useful information emerged suggesting that some of these agents may need to be further tested in specific subgroups of patients, hopefully leading to a more personalized approach to treating COPD.Keywords: anti-inflammatory drugs, COPD, inflammation, treatmenthttps://www.dovepress.com/novel-anti-inflammatory-approaches-to-copd-peer-reviewed-fulltext-article-COPDanti-inflammatory drugscopdinflammationtreatment. |
| spellingShingle | Cazzola M Hanania NA Page CP Matera MG Novel Anti-Inflammatory Approaches to COPD International Journal of COPD anti-inflammatory drugs copd inflammation treatment. |
| title | Novel Anti-Inflammatory Approaches to COPD |
| title_full | Novel Anti-Inflammatory Approaches to COPD |
| title_fullStr | Novel Anti-Inflammatory Approaches to COPD |
| title_full_unstemmed | Novel Anti-Inflammatory Approaches to COPD |
| title_short | Novel Anti-Inflammatory Approaches to COPD |
| title_sort | novel anti inflammatory approaches to copd |
| topic | anti-inflammatory drugs copd inflammation treatment. |
| url | https://www.dovepress.com/novel-anti-inflammatory-approaches-to-copd-peer-reviewed-fulltext-article-COPD |
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