Effects of Betulinic Acid on the Male Reproductive System of a Streptozotocin-Nicotinamide-Induced Diabetic Mouse Model

Effects of Betulinic Acid on the Male Reproductive System of a Streptozotocin-Nicotinamide-Induced Diabetic Mouse Model

Purpose: The present study was conducted to evaluate the favorable or harmful effects of betulinic acid (BA) on a diabetic reproductive system. Materials and Methods: In this experimental study, 60 male Naval Medical Research Institute mice (20∼25 g) were randomly divided into 6 groups: control,...

Full description

Bibliographic Details
Main Authors:	Akram Ahangarpour, Ali Akbar Oroojan, Layasadat Khorsandi, Golshan Arzani, Golshan Afshari
Format:	Article
Language:	English
Published:	Korean Society for Sexual Medicine and Andrology 2016-12-01
Series:	The World Journal of Men's Health
Subjects:	Betulinic acid Diabetes mellitus Mice Spermatozoa Testis
Online Access:	https://www.wjmh.org/Synapse/Data/PDFData/2074WJMH/wjmh-34-209.pdf

Similar Items

Anti-diabetic effect of betulinic acid on streptozotocin-nicotinamide induced diabetic male mouse model
by: Golshan Arzani Birgani, et al.
Published: (2018-07-01)

Preventive effects of betulinic acid on streptozotocinnicotinamide induced diabetic nephropathy in male mouse
by: Akram Ahangarpour, et al.
Published: (2016-10-01)

Hypolipidemic and Hepatoprotective Effects of Myricitrin and Solid Lipid Nanoparticle-containing Myricitrin on the Male Mouse Model with Type 2 Diabetes Induced by Streptozotocin-Nicotinamide
by: Akram Ahangarpour, et al.
Published: (2021-01-01)

The effect of betulinic acid on leptin, adiponectin, hepatic enzyme levels and lipid profiles in streptozotocin-nicotinamide-induced diabetic mice
by: Akram Ahangarpour, et al.
Published: (2018-01-01)

Toxic Effects of Chronic Exposure to High-Fat Diet and Arsenic on the Reproductive System of the Male Mouse
by: Akram Ahangarpour, et al.
Published: (2020-02-01)

Antioxidant, anti-apoptotic, and protective effects of myricitrin and its solid lipid nanoparticle on streptozotocin-nicotinamide-induced diabetic nephropathy in type 2 diabetic male mice
by: Akram Ahangarpour, et al.
Published: (2019-12-01)

Protective Effect of Betulin on Streptozotocin–Nicotinamide-Induced Diabetes in Female Rats
by: Feyisayo O. Adepoju, et al.
Published: (2024-02-01)

Anti-oxidant, anti-apoptotic, and protective effects of myricitrin and its solid lipid nanoparticle on streptozotocin-nicotinamide induced diabetic nephropathy in type 2 diabetic male mice
by: Akram Ahangarpour, et al.
Published: (2023-08-01)

Effects of Bene (Pistacia atlantica) on Histopathology of Testis, Sperm Chromatin Quality and Stress Oxidative in Busulfan-Induced Infertile Mice
by: Hojat Norasteh, et al.
Published: (2019-03-01)

Effects of Dioxin on DNA Damage in the Testes of Adult Male Mice
by: Shabnam Mohammadi, et al.
Published: (2023-12-01)

Effects of Carob (Ceratonia siliqua) on Sperm Quality, Testicular Structure, Testosterone Level and Oxidative Stress in Busulfan-Induced Infertile Mice
by: Azadeh Vafaei, et al.
Published: (2018-06-01)

Preparations of Betulinic Acid Derivatives
by: Mohd Ali, Mohd Tajudin
Published: (2004)

Anti-cancer effect of betulin and its derivatives, with particular emphasis on the treatment of melanoma
by: Justyna Cabaj, et al.
Published: (2021-04-01)

Derivatives of Betulin and Betulinic Acid Containing a Phosphonate Group—In Silico Studies and Preliminary In Vitro Assessment of Antiviral Activity
by: Ewa Bębenek, et al.
Published: (2024-02-01)

Comparision of the Cytotoxic Effects of Birch Bark Extract, Betulin and Betulinic Acid Towards Human Gastric Carcinoma and Pancreatic Carcinoma Drug-sensitive and Drug-Resistant Cell Lines
by: Hermann Lage, et al.
Published: (2009-04-01)

Methods of Betulin Extraction from Birch Bark
by: Olga V. Demets, et al.
Published: (2022-06-01)

CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice
by: Yuki Oyama, et al.
Published: (2022-01-01)

Formulation of nanoemulsions encapsulated with potential anticancer drug, betulinic acid
by: Abdul Rashid, Nur Nadiah
Published: (2014)

Catalytic Sulfation of Betulin with Sulfamic Acid: Experiment and DFT Calculation
by: Aleksandr S. Kazachenko, et al.
Published: (2022-01-01)

The effects of gallic acid and metformin on male reproductive dysfunction in diabetic mice induced by methylglyoxal: An experimental study
by: Zeinab Behdarvand-Margha, et al.
Published: (2021-08-01)

The Effects of Two Species of Daphne, Betulin and Betulinic Acid on Alkaline Phosphatase Activity in Two Human Cancer Cell lines, K562 and MCF-7
by: E Panahi Kokhdan, et al.
Published: (2014-02-01)

Immunomodulatory Effect of Betulinic Acid in Ovalbumin Induced Airway Inflammation in Male Mice
by: Sadia Lodi , Akbar Waheed , Adnan Jehangir , Uzma Naeem , Sher Afghan Khan , Jawaria Iftikhar
Published: (2019-06-01)

The effects of myricitrin and vitamin E against reproductive changes induced by D-galactose as an aging model in female mice: An experimental study
by: Mina Omidi, et al.
Published: (2019-11-01)

Morphology of the male reproductive system and sperm ultrastructure of the green lacewing, Chrysopa pallens (Rambur, 1838) (Neuroptera: Chrysopidae)
by: Xiaoping Liu, et al.
Published: (2023-08-01)

28-<i>O</i>-Acetyl-3-<i>O</i>′-(prop-2-enoyl)betulin
by: Ewa Bębenek, et al.
Published: (2023-07-01)

Betulinic acid and glycyrrhetinic acid derived piperazinyl spacered rhodamine B conjugates are highly cytotoxic and necrotic
by: Marie Kozubek, et al.
Published: (2022-01-01)

Synthesis and Anticancer Activity of Indole-Functionalized Derivatives of Betulin
by: Zuzanna Rzepka, et al.
Published: (2022-11-01)

The Effect of Pentoxiphylin on Histological Changes of Testis and Spermatogenesis Indexes in Mouse Treated With Dexamethasone
by: Nasrin Kheradmand, et al.
Published: (2019-09-01)

Pancreatic protective and hypoglycemic effects of Vitex agnus-castus L. fruit hydroalcoholic extract in D-galactose-induced aging mouse model
by: Akram Ahangarpour, et al.
Published: (2017-01-01)

Protective Effects of Hydroalcoholic Extract of Achillea Millefolium on In-vitro Fertilization in Streptozotocin-Induced Diabetic Male Mice
by: Mohammadreza Hosseinchi, et al.
Published: (2023-01-01)

Long-Term Effect of Aspartame on Male Reproductive System: Evidence for Testicular Histomorphometrics, Hsp70-2 Protein Expression and Biochemical Status
by: Hojat Anbara, et al.
Published: (2020-07-01)

Evaluation of Betulin Mutagenicity by Salmonella/Microsome Test
by: Edson Hideaki Yoshida, et al.
Published: (2016-09-01)

Bioactivity of betulinic acid nanoemulsions on skin carcinogenesis in transgenic mice K14E6
by: B. Agame-Lagunes, et al.
Published: (2021-12-01)

High cytotoxicity of betulin towards fish and murine fibroblasts: Is betulin safe for nonneoplastic cells?
by: Joanna Małaczewska, et al.
Published: (2021-05-01)

Combination of Betulinic Acid Fragments and Carbonic Anhydrase Inhibitors—A New Drug Targeting Approach
by: Matthias Bache, et al.
Published: (2024-03-01)

Sensitization for Anticancer Drug-Induced Apoptosis by Betulinic Acid
by: Simone Fulda, et al.
Published: (2005-02-01)

Acetylenic Synthetic Betulin Derivatives Inhibit Akt and Erk Kinases Activity, Trigger Apoptosis and Suppress Proliferation of Neuroblastoma and Rhabdomyosarcoma Cell Lines
by: Sylwia K. Król, et al.
Published: (2021-11-01)

In Utero Exposure to Metformin Reduces the Fertility of Male Offspring in Adulthood
by: Mélanie C. Faure, et al.
Published: (2021-10-01)

Oleogel Formulations for the Topical Delivery of Betulin and Lupeol in Skin Injuries—Preparation, Physicochemical Characterization, and Pharmaco-Toxicological Evaluation
by: Ramona Daniela Pârvănescu (Pană), et al.
Published: (2021-07-01)

Morphological Changes in Betulin Particles as a Result of Polymorphic Transformations, and Formation of Co-Crystals under Heating
by: Svetlana A. Myz, et al.
Published: (2023-06-01)