Anti-Aging Effect of Chitosan Oligosaccharide on d-Galactose-Induced Subacute Aging in Mice
Chitosan oligosaccharide (COS), a natural polysaccharide with good antioxidant and anti-inflammatory properties, is the depolymerized product of chitosan possessing various biological activities. The present study was designed to investigate the possible anti-aging effect of COS on the aging model m...
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MDPI AG
2018-05-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/16/6/181 |
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| author | Song-Zhi Kong Ji-Cheng Li Si-Dong Li Ming-Neng Liao Cheng-Peng Li Pin-Jin Zheng Min-Hui Guo Wei-Xiang Tan Zhao-Hui Zheng Zhang Hu |
| author_facet | Song-Zhi Kong Ji-Cheng Li Si-Dong Li Ming-Neng Liao Cheng-Peng Li Pin-Jin Zheng Min-Hui Guo Wei-Xiang Tan Zhao-Hui Zheng Zhang Hu |
| author_sort | Song-Zhi Kong |
| collection | DOAJ |
| description | Chitosan oligosaccharide (COS), a natural polysaccharide with good antioxidant and anti-inflammatory properties, is the depolymerized product of chitosan possessing various biological activities. The present study was designed to investigate the possible anti-aging effect of COS on the aging model mouse induced by d-galactose (d-gal) and explore the underlying mechanism. In the experiment, 48 male Kunming mice (KM mice) were randomly divided into the normal group, model group, positive group, and low-medium-high dose polysaccharide groups (300, 600, 1200 mg/kg/day). The results showed that COS, by intragastric gavage after subcutaneous injection of d-gal (250 mg/kg/day) into the neck of mice consecutively for eight weeks, gradually recovered the body weight, the activity of daily living, and organ indices of mice, as well as effectively ameliorated the histological deterioration of the liver and kidney in mice triggered by d-gal. To be specific, COS obviously improved the activities of antioxidant enzymes in liver and kidney of KM mice, including catalase (CAT), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD), as well as decreased malondialdehyde (MDA) levels when compared with those in model group mice. Furthermore, COS not only elevated the diminished levels of serum immunoglobulin G (IgG) and IgM induced by d-gal, but also significantly inhibited the d-gal-caused upregulation of serum alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), uric acid (UA) and creatinine (CREA) levels as compared with those of mice in the model group. These results demonstrate that COS has an obvious anti-aging activity in d-gal-induced subacute aging mice, the mechanism of which, to some extent, is associated with enhancing the antioxidant defenses, reducing oxidative stress, and improving the immune function of aging model mice. |
| first_indexed | 2024-04-14T03:35:47Z |
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| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T03:35:47Z |
| publishDate | 2018-05-01 |
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| series | Marine Drugs |
| spelling | doaj.art-6a54585a81a946a6ba06986b815bdb4e2022-12-22T02:14:46ZengMDPI AGMarine Drugs1660-33972018-05-0116618110.3390/md16060181md16060181Anti-Aging Effect of Chitosan Oligosaccharide on d-Galactose-Induced Subacute Aging in MiceSong-Zhi Kong0Ji-Cheng Li1Si-Dong Li2Ming-Neng Liao3Cheng-Peng Li4Pin-Jin Zheng5Min-Hui Guo6Wei-Xiang Tan7Zhao-Hui Zheng8Zhang Hu9Faculty of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, ChinaFaculty of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, ChinaFaculty of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, ChinaFaculty of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, ChinaFaculty of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, ChinaFaculty of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, ChinaFaculty of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, ChinaFaculty of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, ChinaFaculty of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, ChinaFaculty of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, ChinaChitosan oligosaccharide (COS), a natural polysaccharide with good antioxidant and anti-inflammatory properties, is the depolymerized product of chitosan possessing various biological activities. The present study was designed to investigate the possible anti-aging effect of COS on the aging model mouse induced by d-galactose (d-gal) and explore the underlying mechanism. In the experiment, 48 male Kunming mice (KM mice) were randomly divided into the normal group, model group, positive group, and low-medium-high dose polysaccharide groups (300, 600, 1200 mg/kg/day). The results showed that COS, by intragastric gavage after subcutaneous injection of d-gal (250 mg/kg/day) into the neck of mice consecutively for eight weeks, gradually recovered the body weight, the activity of daily living, and organ indices of mice, as well as effectively ameliorated the histological deterioration of the liver and kidney in mice triggered by d-gal. To be specific, COS obviously improved the activities of antioxidant enzymes in liver and kidney of KM mice, including catalase (CAT), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD), as well as decreased malondialdehyde (MDA) levels when compared with those in model group mice. Furthermore, COS not only elevated the diminished levels of serum immunoglobulin G (IgG) and IgM induced by d-gal, but also significantly inhibited the d-gal-caused upregulation of serum alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), uric acid (UA) and creatinine (CREA) levels as compared with those of mice in the model group. These results demonstrate that COS has an obvious anti-aging activity in d-gal-induced subacute aging mice, the mechanism of which, to some extent, is associated with enhancing the antioxidant defenses, reducing oxidative stress, and improving the immune function of aging model mice.http://www.mdpi.com/1660-3397/16/6/181chitosan oligosaccharided-galactosesubacute aginganti-aginganti-oxidantimmune function |
| spellingShingle | Song-Zhi Kong Ji-Cheng Li Si-Dong Li Ming-Neng Liao Cheng-Peng Li Pin-Jin Zheng Min-Hui Guo Wei-Xiang Tan Zhao-Hui Zheng Zhang Hu Anti-Aging Effect of Chitosan Oligosaccharide on d-Galactose-Induced Subacute Aging in Mice Marine Drugs chitosan oligosaccharide d-galactose subacute aging anti-aging anti-oxidant immune function |
| title | Anti-Aging Effect of Chitosan Oligosaccharide on d-Galactose-Induced Subacute Aging in Mice |
| title_full | Anti-Aging Effect of Chitosan Oligosaccharide on d-Galactose-Induced Subacute Aging in Mice |
| title_fullStr | Anti-Aging Effect of Chitosan Oligosaccharide on d-Galactose-Induced Subacute Aging in Mice |
| title_full_unstemmed | Anti-Aging Effect of Chitosan Oligosaccharide on d-Galactose-Induced Subacute Aging in Mice |
| title_short | Anti-Aging Effect of Chitosan Oligosaccharide on d-Galactose-Induced Subacute Aging in Mice |
| title_sort | anti aging effect of chitosan oligosaccharide on d galactose induced subacute aging in mice |
| topic | chitosan oligosaccharide d-galactose subacute aging anti-aging anti-oxidant immune function |
| url | http://www.mdpi.com/1660-3397/16/6/181 |
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