Prognostic factors for sublingual gland carcinoma: a population-based Surveillance, Epidemiology and End Results database study
Objective To identify the clinical features and prognostic factors for sublingual gland carcinoma. Methods This was a case–control study. Patients with surgically treated sublingual gland carcinoma were retrospectively included in the Surveillance, Epidemiology and End Results database and divided i...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-11-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605231187940 |
| _version_ | 1797632552059535360 |
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| author | Gang Qin Lei Wu Chengxia Li Qian Zhang Zhongjun An Jianhua Qin |
| author_facet | Gang Qin Lei Wu Chengxia Li Qian Zhang Zhongjun An Jianhua Qin |
| author_sort | Gang Qin |
| collection | DOAJ |
| description | Objective To identify the clinical features and prognostic factors for sublingual gland carcinoma. Methods This was a case–control study. Patients with surgically treated sublingual gland carcinoma were retrospectively included in the Surveillance, Epidemiology and End Results database and divided into adenoid cystic carcinoma (ACC) and non-ACC groups. Primary outcome variables were disease-specific survival (DSS) and overall survival (OS). Prognostic factors for each group were analyzed using Cox models. Results We included 251 patients (115 men and 136 women). Compared with the non-ACC group, the ACC group had a larger average tumor size and received more adjuvant radiotherapy. In patients with ACC, the pathologic grade had an independent impact on DSS and OS, and patients who were undergoing adjuvant chemotherapy had worse DSS than those who were not receiving chemotherapy. In the non-ACC group, pathologic grade IV, lymph node metastasis, and adjuvant chemotherapy were associated with poor DSS and OS, and tumor extension predicted worsening DSS. Conclusions In sublingual gland carcinoma, the pathologic grade and adjuvant chemotherapy were the most important prognostic factors, whereas lymph node metastasis had a negative impact in non-ACC patients but not in ACC patients. |
| first_indexed | 2024-03-11T11:39:34Z |
| format | Article |
| id | doaj.art-6a54688e4e2c45949175ec811824e46c |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-03-11T11:39:34Z |
| publishDate | 2023-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-6a54688e4e2c45949175ec811824e46c2023-11-10T08:03:27ZengSAGE PublishingJournal of International Medical Research1473-23002023-11-015110.1177/03000605231187940Prognostic factors for sublingual gland carcinoma: a population-based Surveillance, Epidemiology and End Results database studyGang QinLei WuChengxia LiQian ZhangZhongjun AnJianhua QinObjective To identify the clinical features and prognostic factors for sublingual gland carcinoma. Methods This was a case–control study. Patients with surgically treated sublingual gland carcinoma were retrospectively included in the Surveillance, Epidemiology and End Results database and divided into adenoid cystic carcinoma (ACC) and non-ACC groups. Primary outcome variables were disease-specific survival (DSS) and overall survival (OS). Prognostic factors for each group were analyzed using Cox models. Results We included 251 patients (115 men and 136 women). Compared with the non-ACC group, the ACC group had a larger average tumor size and received more adjuvant radiotherapy. In patients with ACC, the pathologic grade had an independent impact on DSS and OS, and patients who were undergoing adjuvant chemotherapy had worse DSS than those who were not receiving chemotherapy. In the non-ACC group, pathologic grade IV, lymph node metastasis, and adjuvant chemotherapy were associated with poor DSS and OS, and tumor extension predicted worsening DSS. Conclusions In sublingual gland carcinoma, the pathologic grade and adjuvant chemotherapy were the most important prognostic factors, whereas lymph node metastasis had a negative impact in non-ACC patients but not in ACC patients.https://doi.org/10.1177/03000605231187940 |
| spellingShingle | Gang Qin Lei Wu Chengxia Li Qian Zhang Zhongjun An Jianhua Qin Prognostic factors for sublingual gland carcinoma: a population-based Surveillance, Epidemiology and End Results database study Journal of International Medical Research |
| title | Prognostic factors for sublingual gland carcinoma: a population-based Surveillance, Epidemiology and End Results database study |
| title_full | Prognostic factors for sublingual gland carcinoma: a population-based Surveillance, Epidemiology and End Results database study |
| title_fullStr | Prognostic factors for sublingual gland carcinoma: a population-based Surveillance, Epidemiology and End Results database study |
| title_full_unstemmed | Prognostic factors for sublingual gland carcinoma: a population-based Surveillance, Epidemiology and End Results database study |
| title_short | Prognostic factors for sublingual gland carcinoma: a population-based Surveillance, Epidemiology and End Results database study |
| title_sort | prognostic factors for sublingual gland carcinoma a population based surveillance epidemiology and end results database study |
| url | https://doi.org/10.1177/03000605231187940 |
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