Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) represent two ends of a disease spectrum with shared clinical, genetic and pathological features. These include near ubiquitous pathological inclusions of the RNA-binding protein (RBP) TDP-43, and often the presence of a GGGGCC ex...
Main Authors: | Erin G Conlon, Delphine Fagegaltier, Phaedra Agius, Julia Davis-Porada, James Gregory, Isabel Hubbard, Kristy Kang, Duyang Kim, The New York Genome Center ALS Consortium, Hemali Phatnani, Neil A Shneider, James L Manley |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2018-07-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/37754 |
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