GCN5L1 impairs diastolic function in mice exposed to a high fat diet by restricting cardiac pyruvate oxidation

GCN5L1 impairs diastolic function in mice exposed to a high fat diet by restricting cardiac pyruvate oxidation

Abstract Left ventricular diastolic dysfunction is a structural and functional condition that precedes the development of heart failure with preserved ejection fraction (HFpEF). The etiology of diastolic dysfunction includes alterations in fuel substrate metabolism that negatively impact cardiac bio...

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Bibliographic Details
Main Authors: Dharendra Thapa, Paramesha Bugga, Bellina A. S. Mushala, Janet R. Manning, Michael W. Stoner, Brenda McMahon, Xuemei Zeng, Pamela S. Cantrell, Nathan Yates, Bingxian Xie, Lia R. Edmunds, Michael J. Jurczak, Iain Scott
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Physiological Reports
Subjects:
acetylation
diastolic dysfunction
heart failure
mitochondria
pyruvate dehydrogenase
Online Access:https://doi.org/10.14814/phy2.15415

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