Harmine Ameliorates Cognitive Impairment by Inhibiting NLRP3 Inflammasome Activation and Enhancing the BDNF/TrkB Signaling Pathway in STZ-Induced Diabetic Rats

Harmine Ameliorates Cognitive Impairment by Inhibiting NLRP3 Inflammasome Activation and Enhancing the BDNF/TrkB Signaling Pathway in STZ-Induced Diabetic Rats

Diabetes mellitus (DM) is considered a risk factor for cognitive dysfunction. Harmine not only effectively improves the symptoms of DM but also provides neuroprotective effects in central nervous system diseases. However, whether harmine has an effect on diabetes-induced cognitive dysfunction and th...

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Bibliographic Details
Main Authors: Peifang Liu, Hui Li, Yueqiu Wang, Xiaolin Su, Yang Li, Meiling Yan, Lan Ma, Hui Che
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
harmine
diabetes mellitus
cognitive dysfunction
NLRP3 inflammasome
BDNF
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00535/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00535/full

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