Harnessing Mechanosensation in Next Generation Cardiovascular Tissue Engineering
The ability of the cells to sense mechanical cues is an integral component of ”social” cell behavior inside tissues with a complex architecture. Through ”mechanosensation” cells are in fact able to decrypt motion, geometries and physical information of surrounding cells and extracellular matrices by...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/10/10/1419 |
| _version_ | 1827704765925031936 |
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| author | Gloria Garoffolo Silvia Ferrari Stefano Rizzi Marianna Barbuto Giacomo Bernava Maurizio Pesce |
| author_facet | Gloria Garoffolo Silvia Ferrari Stefano Rizzi Marianna Barbuto Giacomo Bernava Maurizio Pesce |
| author_sort | Gloria Garoffolo |
| collection | DOAJ |
| description | The ability of the cells to sense mechanical cues is an integral component of ”social” cell behavior inside tissues with a complex architecture. Through ”mechanosensation” cells are in fact able to decrypt motion, geometries and physical information of surrounding cells and extracellular matrices by activating intracellular pathways converging onto gene expression circuitries controlling cell and tissue homeostasis. Additionally, only recently cell mechanosensation has been integrated systematically as a crucial element in tissue pathophysiology. In the present review, we highlight some of the current efforts to assess the relevance of mechanical sensing into pathology modeling and manufacturing criteria for a next generation of cardiovascular tissue implants. |
| first_indexed | 2024-03-10T15:47:49Z |
| format | Article |
| id | doaj.art-6a5b01b6cb6340b28af5046669033a1c |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T15:47:49Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-6a5b01b6cb6340b28af5046669033a1c2023-11-20T16:18:43ZengMDPI AGBiomolecules2218-273X2020-10-011010141910.3390/biom10101419Harnessing Mechanosensation in Next Generation Cardiovascular Tissue EngineeringGloria Garoffolo0Silvia Ferrari1Stefano Rizzi2Marianna Barbuto3Giacomo Bernava4Maurizio Pesce5Unità di Ingegneria Tissutale Cardiovascolare, Centro Cardiologico Monzino, IRCCS, 20138 Milan, ItalyUnità di Ingegneria Tissutale Cardiovascolare, Centro Cardiologico Monzino, IRCCS, 20138 Milan, ItalyUnità di Ingegneria Tissutale Cardiovascolare, Centro Cardiologico Monzino, IRCCS, 20138 Milan, ItalyUnità di Ingegneria Tissutale Cardiovascolare, Centro Cardiologico Monzino, IRCCS, 20138 Milan, ItalyUnità di Ingegneria Tissutale Cardiovascolare, Centro Cardiologico Monzino, IRCCS, 20138 Milan, ItalyUnità di Ingegneria Tissutale Cardiovascolare, Centro Cardiologico Monzino, IRCCS, 20138 Milan, ItalyThe ability of the cells to sense mechanical cues is an integral component of ”social” cell behavior inside tissues with a complex architecture. Through ”mechanosensation” cells are in fact able to decrypt motion, geometries and physical information of surrounding cells and extracellular matrices by activating intracellular pathways converging onto gene expression circuitries controlling cell and tissue homeostasis. Additionally, only recently cell mechanosensation has been integrated systematically as a crucial element in tissue pathophysiology. In the present review, we highlight some of the current efforts to assess the relevance of mechanical sensing into pathology modeling and manufacturing criteria for a next generation of cardiovascular tissue implants.https://www.mdpi.com/2218-273X/10/10/1419mechanosensingcardiac regenerationtissue engineering |
| spellingShingle | Gloria Garoffolo Silvia Ferrari Stefano Rizzi Marianna Barbuto Giacomo Bernava Maurizio Pesce Harnessing Mechanosensation in Next Generation Cardiovascular Tissue Engineering Biomolecules mechanosensing cardiac regeneration tissue engineering |
| title | Harnessing Mechanosensation in Next Generation Cardiovascular Tissue Engineering |
| title_full | Harnessing Mechanosensation in Next Generation Cardiovascular Tissue Engineering |
| title_fullStr | Harnessing Mechanosensation in Next Generation Cardiovascular Tissue Engineering |
| title_full_unstemmed | Harnessing Mechanosensation in Next Generation Cardiovascular Tissue Engineering |
| title_short | Harnessing Mechanosensation in Next Generation Cardiovascular Tissue Engineering |
| title_sort | harnessing mechanosensation in next generation cardiovascular tissue engineering |
| topic | mechanosensing cardiac regeneration tissue engineering |
| url | https://www.mdpi.com/2218-273X/10/10/1419 |
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