Thermodynamic bifurcation in anoxic heart: A far-from-equilibrium dissipative structure.
Thermodynamic consequences of a three-hour long anoxia were investigated on the isolated mammalian rat myocardium. The anoxic heart operated in a far-from-equilibrium manner as attested by the non-linearity between the thermodynamic force and the thermodynamic flow. When subjected to slight fluctuat...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0298979&type=printable |
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| author | Yves Lecarpentier Olivier Schussler Victor Claes Jean-Louis Hébert Xénophon Krokidis Alexandre Vallée |
| author_facet | Yves Lecarpentier Olivier Schussler Victor Claes Jean-Louis Hébert Xénophon Krokidis Alexandre Vallée |
| author_sort | Yves Lecarpentier |
| collection | DOAJ |
| description | Thermodynamic consequences of a three-hour long anoxia were investigated on the isolated mammalian rat myocardium. The anoxic heart operated in a far-from-equilibrium manner as attested by the non-linearity between the thermodynamic force and the thermodynamic flow. When subjected to slight fluctuations due to anoxia, the open far-from-equilibrium cardiac system presented a thermodynamic bifurcation at ~ 60 minutes of anoxia. The bifurcation was characterized by a sudden change of direction in the bifurcation diagram of a one-dimensional nonlinear differential equation with one parameter and occurred at a non-hyperbolic fixed point at which moment the heart lost its thermodynamic stability. The parameter of the differential equation was the single force of the myosin molecular motor. These results helped to reflect a self-organized process and the occurrence of a dissipative structure. This offers valuable insights into our understanding of myocardial protection and could be of considerable interest, especially for heart transplants where the recipient must benefit from the donor's heart in the shortest possible time. |
| first_indexed | 2024-04-25T00:14:32Z |
| format | Article |
| id | doaj.art-6a5e67d503114ba7b282bf63d57d43e2 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-25T00:14:32Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-6a5e67d503114ba7b282bf63d57d43e22024-03-13T05:31:18ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01193e029897910.1371/journal.pone.0298979Thermodynamic bifurcation in anoxic heart: A far-from-equilibrium dissipative structure.Yves LecarpentierOlivier SchusslerVictor ClaesJean-Louis HébertXénophon KrokidisAlexandre ValléeThermodynamic consequences of a three-hour long anoxia were investigated on the isolated mammalian rat myocardium. The anoxic heart operated in a far-from-equilibrium manner as attested by the non-linearity between the thermodynamic force and the thermodynamic flow. When subjected to slight fluctuations due to anoxia, the open far-from-equilibrium cardiac system presented a thermodynamic bifurcation at ~ 60 minutes of anoxia. The bifurcation was characterized by a sudden change of direction in the bifurcation diagram of a one-dimensional nonlinear differential equation with one parameter and occurred at a non-hyperbolic fixed point at which moment the heart lost its thermodynamic stability. The parameter of the differential equation was the single force of the myosin molecular motor. These results helped to reflect a self-organized process and the occurrence of a dissipative structure. This offers valuable insights into our understanding of myocardial protection and could be of considerable interest, especially for heart transplants where the recipient must benefit from the donor's heart in the shortest possible time.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0298979&type=printable |
| spellingShingle | Yves Lecarpentier Olivier Schussler Victor Claes Jean-Louis Hébert Xénophon Krokidis Alexandre Vallée Thermodynamic bifurcation in anoxic heart: A far-from-equilibrium dissipative structure. PLoS ONE |
| title | Thermodynamic bifurcation in anoxic heart: A far-from-equilibrium dissipative structure. |
| title_full | Thermodynamic bifurcation in anoxic heart: A far-from-equilibrium dissipative structure. |
| title_fullStr | Thermodynamic bifurcation in anoxic heart: A far-from-equilibrium dissipative structure. |
| title_full_unstemmed | Thermodynamic bifurcation in anoxic heart: A far-from-equilibrium dissipative structure. |
| title_short | Thermodynamic bifurcation in anoxic heart: A far-from-equilibrium dissipative structure. |
| title_sort | thermodynamic bifurcation in anoxic heart a far from equilibrium dissipative structure |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0298979&type=printable |
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