Anti Candidal Activity of Echinophora platyloba Against Candida albicans and Comparison with Amphotricin
Background & Aim: Increasing usage of medical plants for medical treatment made for this branch of complementary medicine a unique place. Methods: This study evaluated the anti candidal activity of Echinophora platyloba extracts and amphotricin B against Candida albicans by micro broth dilution...
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| Format: | Article |
| Language: | English |
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Institue of Medicinal Plants, ACECR
2009-05-01
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| Series: | Journal of Medicinal Plants |
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| Online Access: | http://jmp.ir/article-1-363-en.html |
| _version_ | 1819122329450446848 |
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| author | M Mahboubi M Avijgan M Darabi N Kasaiyan |
| author_facet | M Mahboubi M Avijgan M Darabi N Kasaiyan |
| author_sort | M Mahboubi |
| collection | DOAJ |
| description | Background & Aim: Increasing usage of medical plants for medical treatment made for this branch of complementary medicine a unique place. Methods: This study evaluated the anti candidal activity of Echinophora platyloba extracts and amphotricin B against Candida albicans by micro broth dilution assay and Disc diffusion method. The synergism between amphotricin B and ethanolic extract of E. platyloba was assessed by micro broth dilution assay. Amphotricin B was diluted at concentration between 16-0.125 µg ml-1. Each tube contains 0.78 mg ml-1 E. platyloba extract. The MIC and MBC of Amphotricin B was recorded. Results: The MIC and MBC of ethanolic extract of E. platyloba and amphotricin B against C. albicans were 3125, 1560 µg ml-1 and 2, 8 µg ml-1 respectively. The MIC, MBC of amphotricin B decreased to 1, 2 µg ml-1 when 0.78 mg ml-1 of extract was added. Conclusion: Amphotricin B is a potent antifungal agent and MIC and MBC of E. platyloba is 780, 390 times less potent than amphotricin B, but usage the amphotricin B and E. platyloba extract in combination increased the potency of amphotricin B which shows a synergistic effect. |
| first_indexed | 2024-12-22T06:50:43Z |
| format | Article |
| id | doaj.art-6a609184cf744111895cdbcf5a813dbf |
| institution | Directory Open Access Journal |
| issn | 2717-204X 2717-2058 |
| language | English |
| last_indexed | 2024-12-22T06:50:43Z |
| publishDate | 2009-05-01 |
| publisher | Institue of Medicinal Plants, ACECR |
| record_format | Article |
| series | Journal of Medicinal Plants |
| spelling | doaj.art-6a609184cf744111895cdbcf5a813dbf2022-12-21T18:35:10ZengInstitue of Medicinal Plants, ACECRJournal of Medicinal Plants2717-204X2717-20582009-05-018303643Anti Candidal Activity of Echinophora platyloba Against Candida albicans and Comparison with AmphotricinM Mahboubi0M Avijgan1M Darabi2N Kasaiyan3 Department of Microbiology, Barij Essence Pharmaceutical Company, Kashan, Iran Departement of Infectious and Tropical Diseases, Isfahan University of Medical Sciences, Isfahan, Iran Department of Microbiology, Barij Essence Pharmaceutical Company, Kashan, Iran Departement of Infectious and Tropical Diseases, Isfahan University of Medical Sciences, Isfahan, Iran Background & Aim: Increasing usage of medical plants for medical treatment made for this branch of complementary medicine a unique place. Methods: This study evaluated the anti candidal activity of Echinophora platyloba extracts and amphotricin B against Candida albicans by micro broth dilution assay and Disc diffusion method. The synergism between amphotricin B and ethanolic extract of E. platyloba was assessed by micro broth dilution assay. Amphotricin B was diluted at concentration between 16-0.125 µg ml-1. Each tube contains 0.78 mg ml-1 E. platyloba extract. The MIC and MBC of Amphotricin B was recorded. Results: The MIC and MBC of ethanolic extract of E. platyloba and amphotricin B against C. albicans were 3125, 1560 µg ml-1 and 2, 8 µg ml-1 respectively. The MIC, MBC of amphotricin B decreased to 1, 2 µg ml-1 when 0.78 mg ml-1 of extract was added. Conclusion: Amphotricin B is a potent antifungal agent and MIC and MBC of E. platyloba is 780, 390 times less potent than amphotricin B, but usage the amphotricin B and E. platyloba extract in combination increased the potency of amphotricin B which shows a synergistic effect.http://jmp.ir/article-1-363-en.htmlamphotricin bechinophora platylobaextractdermatophytesyeast |
| spellingShingle | M Mahboubi M Avijgan M Darabi N Kasaiyan Anti Candidal Activity of Echinophora platyloba Against Candida albicans and Comparison with Amphotricin Journal of Medicinal Plants amphotricin b echinophora platyloba extract dermatophytes yeast |
| title | Anti Candidal Activity of Echinophora platyloba Against Candida albicans and Comparison with Amphotricin |
| title_full | Anti Candidal Activity of Echinophora platyloba Against Candida albicans and Comparison with Amphotricin |
| title_fullStr | Anti Candidal Activity of Echinophora platyloba Against Candida albicans and Comparison with Amphotricin |
| title_full_unstemmed | Anti Candidal Activity of Echinophora platyloba Against Candida albicans and Comparison with Amphotricin |
| title_short | Anti Candidal Activity of Echinophora platyloba Against Candida albicans and Comparison with Amphotricin |
| title_sort | anti candidal activity of echinophora platyloba against candida albicans and comparison with amphotricin |
| topic | amphotricin b echinophora platyloba extract dermatophytes yeast |
| url | http://jmp.ir/article-1-363-en.html |
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