Mechanical Loading-Driven Tumor Suppression Is Mediated by Lrp5-Dependent and Independent Mechanisms

Mechanical Loading-Driven Tumor Suppression Is Mediated by Lrp5-Dependent and Independent Mechanisms

Bone is mechanosensitive and lipoprotein receptor-related protein 5 (Lrp5)-mediated Wnt signaling promotes loading-driven bone formation. While mechanical loading can suppress tumor growth, the question is whether Lrp5 mediates loading-driven tumor suppression. Herein, we examined the effect of Lrp5...

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Bibliographic Details
Main Authors: Yan Feng, Shengzhi Liu, Rongrong Zha, Xun Sun, Kexin Li, Alexander Robling, Baiyan Li, Hiroki Yokota
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
breast cancer
prostate cancer
mechanical stimulation
osteocyte
Lrp5
chemerin
Online Access:https://www.mdpi.com/2072-6694/13/2/267

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