Tight Junctions as Targets and Effectors of Mucosal Immune HomeostasisSummary
Defective epithelial barrier function is present in maladies including epidermal burn injury, environmental lung damage, renal tubular disease, and a range of immune-mediated and infectious intestinal disorders. When the epithelial surface is intact, the paracellular pathway between cells is sealed...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Cellular and Molecular Gastroenterology and Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352345X2030045X |
| _version_ | 1818527205238505472 |
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| author | Li Zuo Wei-Ting Kuo Jerrold R. Turner |
| author_facet | Li Zuo Wei-Ting Kuo Jerrold R. Turner |
| author_sort | Li Zuo |
| collection | DOAJ |
| description | Defective epithelial barrier function is present in maladies including epidermal burn injury, environmental lung damage, renal tubular disease, and a range of immune-mediated and infectious intestinal disorders. When the epithelial surface is intact, the paracellular pathway between cells is sealed by the tight junction. However, permeability of tight junctions varies widely across tissues and can be markedly impacted by disease. For example, tight junctions within the skin and urinary bladder are largely impermeant and their permeability is not regulated. In contrast, tight junctions of the proximal renal tubule and intestine are selectively permeable to water and solutes on the basis of their biophysical characteristics and, in the gut, can be regulated by the immune system with remarkable specificity. Conversely, modulation of tight junction barrier conductance, especially within the gastrointestinal tract, can impact immune homeostasis and diverse pathologies. Thus, tight junctions are both effectors and targets of immune regulation. Using the gastrointestinal tract as an example, this review explores current understanding of this complex interplay between tight junctions and immunity. |
| first_indexed | 2024-12-11T06:33:09Z |
| format | Article |
| id | doaj.art-6a61d046ffd642dfb33ca657216eb0ef |
| institution | Directory Open Access Journal |
| issn | 2352-345X |
| language | English |
| last_indexed | 2024-12-11T06:33:09Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cellular and Molecular Gastroenterology and Hepatology |
| spelling | doaj.art-6a61d046ffd642dfb33ca657216eb0ef2022-12-22T01:17:27ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2020-01-01102327340Tight Junctions as Targets and Effectors of Mucosal Immune HomeostasisSummaryLi Zuo0Wei-Ting Kuo1Jerrold R. Turner2Anhui Medical University, Hefei, Anhui, China; Laboratory of Mucosal Barrier Pathophysiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MassachusettsLaboratory of Mucosal Barrier Pathophysiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MassachusettsLaboratory of Mucosal Barrier Pathophysiology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts; Correspondence Address correspondence to: Jerrold R. Turner, MD, PhD, Brigham and Women’s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, HNRB 730B, Boston, Massachusetts 02115.Defective epithelial barrier function is present in maladies including epidermal burn injury, environmental lung damage, renal tubular disease, and a range of immune-mediated and infectious intestinal disorders. When the epithelial surface is intact, the paracellular pathway between cells is sealed by the tight junction. However, permeability of tight junctions varies widely across tissues and can be markedly impacted by disease. For example, tight junctions within the skin and urinary bladder are largely impermeant and their permeability is not regulated. In contrast, tight junctions of the proximal renal tubule and intestine are selectively permeable to water and solutes on the basis of their biophysical characteristics and, in the gut, can be regulated by the immune system with remarkable specificity. Conversely, modulation of tight junction barrier conductance, especially within the gastrointestinal tract, can impact immune homeostasis and diverse pathologies. Thus, tight junctions are both effectors and targets of immune regulation. Using the gastrointestinal tract as an example, this review explores current understanding of this complex interplay between tight junctions and immunity.http://www.sciencedirect.com/science/article/pii/S2352345X2030045XIntestinal PermeabilityBarrierMyosin Light Chain KinaseEnteric InfectionInflammatory Bowel DiseaseGraft-Versus-Host Disease |
| spellingShingle | Li Zuo Wei-Ting Kuo Jerrold R. Turner Tight Junctions as Targets and Effectors of Mucosal Immune HomeostasisSummary Cellular and Molecular Gastroenterology and Hepatology Intestinal Permeability Barrier Myosin Light Chain Kinase Enteric Infection Inflammatory Bowel Disease Graft-Versus-Host Disease |
| title | Tight Junctions as Targets and Effectors of Mucosal Immune HomeostasisSummary |
| title_full | Tight Junctions as Targets and Effectors of Mucosal Immune HomeostasisSummary |
| title_fullStr | Tight Junctions as Targets and Effectors of Mucosal Immune HomeostasisSummary |
| title_full_unstemmed | Tight Junctions as Targets and Effectors of Mucosal Immune HomeostasisSummary |
| title_short | Tight Junctions as Targets and Effectors of Mucosal Immune HomeostasisSummary |
| title_sort | tight junctions as targets and effectors of mucosal immune homeostasissummary |
| topic | Intestinal Permeability Barrier Myosin Light Chain Kinase Enteric Infection Inflammatory Bowel Disease Graft-Versus-Host Disease |
| url | http://www.sciencedirect.com/science/article/pii/S2352345X2030045X |
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