Epigenetic silencing of miR-338-3p contributes to tumorigenicity in gastric cancer by targeting SSX2IP.
MicroRNA has been recently recognized as playing a prominent role in tumorigenesis and metastasis. Here, we report that miR-338-3p was epigenetically silenced in gastric cancer, and its down-regulation was significantly correlated with gastric cancer clinicopathological features. Strikingly, restori...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3691322?pdf=render |
| _version_ | 1818579163658846208 |
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| author | Pu Li Xuehua Chen Liping Su Chenglong Li Qiaoming Zhi Beiqin Yu Hong Sheng Junqing Wang Runhua Feng Qu Cai Jianfang Li Yingyan Yu Min Yan Bingya Liu Zhenggang Zhu |
| author_facet | Pu Li Xuehua Chen Liping Su Chenglong Li Qiaoming Zhi Beiqin Yu Hong Sheng Junqing Wang Runhua Feng Qu Cai Jianfang Li Yingyan Yu Min Yan Bingya Liu Zhenggang Zhu |
| author_sort | Pu Li |
| collection | DOAJ |
| description | MicroRNA has been recently recognized as playing a prominent role in tumorigenesis and metastasis. Here, we report that miR-338-3p was epigenetically silenced in gastric cancer, and its down-regulation was significantly correlated with gastric cancer clinicopathological features. Strikingly, restoring miR-338-3p expression in SGC-7901 gastric cancer cells inhibited proliferation, migration, invasion and tumorigenicity in vitro and in vivo, at least partly through inducing apoptosis. Furthermore, we demonstrate the oncogene SSX2IP is a target of miR-338-3p. We propose that miR-338-3p functions as a tumor suppressor in gastric cancer, and the methylation status of its CpG island could serve as a potential diagnostic marker for gastric cancer. |
| first_indexed | 2024-12-16T06:57:20Z |
| format | Article |
| id | doaj.art-6a61e216d4254813baab161510877561 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T06:57:20Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6a61e216d4254813baab1615108775612022-12-21T22:40:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0186e6678210.1371/journal.pone.0066782Epigenetic silencing of miR-338-3p contributes to tumorigenicity in gastric cancer by targeting SSX2IP.Pu LiXuehua ChenLiping SuChenglong LiQiaoming ZhiBeiqin YuHong ShengJunqing WangRunhua FengQu CaiJianfang LiYingyan YuMin YanBingya LiuZhenggang ZhuMicroRNA has been recently recognized as playing a prominent role in tumorigenesis and metastasis. Here, we report that miR-338-3p was epigenetically silenced in gastric cancer, and its down-regulation was significantly correlated with gastric cancer clinicopathological features. Strikingly, restoring miR-338-3p expression in SGC-7901 gastric cancer cells inhibited proliferation, migration, invasion and tumorigenicity in vitro and in vivo, at least partly through inducing apoptosis. Furthermore, we demonstrate the oncogene SSX2IP is a target of miR-338-3p. We propose that miR-338-3p functions as a tumor suppressor in gastric cancer, and the methylation status of its CpG island could serve as a potential diagnostic marker for gastric cancer.http://europepmc.org/articles/PMC3691322?pdf=render |
| spellingShingle | Pu Li Xuehua Chen Liping Su Chenglong Li Qiaoming Zhi Beiqin Yu Hong Sheng Junqing Wang Runhua Feng Qu Cai Jianfang Li Yingyan Yu Min Yan Bingya Liu Zhenggang Zhu Epigenetic silencing of miR-338-3p contributes to tumorigenicity in gastric cancer by targeting SSX2IP. PLoS ONE |
| title | Epigenetic silencing of miR-338-3p contributes to tumorigenicity in gastric cancer by targeting SSX2IP. |
| title_full | Epigenetic silencing of miR-338-3p contributes to tumorigenicity in gastric cancer by targeting SSX2IP. |
| title_fullStr | Epigenetic silencing of miR-338-3p contributes to tumorigenicity in gastric cancer by targeting SSX2IP. |
| title_full_unstemmed | Epigenetic silencing of miR-338-3p contributes to tumorigenicity in gastric cancer by targeting SSX2IP. |
| title_short | Epigenetic silencing of miR-338-3p contributes to tumorigenicity in gastric cancer by targeting SSX2IP. |
| title_sort | epigenetic silencing of mir 338 3p contributes to tumorigenicity in gastric cancer by targeting ssx2ip |
| url | http://europepmc.org/articles/PMC3691322?pdf=render |
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