Recent advances in understanding spondyloarthritis [version 1; referees: 2 approved]
This review is concerned with a number of recent publications that contribute to current thinking on the pathogenesis of spondyloarthritis. The areas covered include the lymphocyte population in the enthesis, which is thought to drive enthesitis, and hence clinical manifestations. The debate on how...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2017-03-01
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| Series: | F1000Research |
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| Online Access: | https://f1000research.com/articles/6-304/v1 |
| _version_ | 1818528303427878912 |
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| author | J.S.H. Gaston |
| author_facet | J.S.H. Gaston |
| author_sort | J.S.H. Gaston |
| collection | DOAJ |
| description | This review is concerned with a number of recent publications that contribute to current thinking on the pathogenesis of spondyloarthritis. The areas covered include the lymphocyte population in the enthesis, which is thought to drive enthesitis, and hence clinical manifestations. The debate on how HLA-B27 is implicated in inflammation is also considered, together with recent and contradictory evidence on the effects of the peptide-trimming enzyme ERAP1 on B27 expression and hence susceptibility to spondylitis. Lastly, a recent report on the role of the gut microbiome in an important model of spondyloarthritis is considered. |
| first_indexed | 2024-12-11T06:48:02Z |
| format | Article |
| id | doaj.art-6a64262c5559443aac99f3c2a5c6ffcc |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-11T06:48:02Z |
| publishDate | 2017-03-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-6a64262c5559443aac99f3c2a5c6ffcc2022-12-22T01:17:01ZengF1000 Research LtdF1000Research2046-14022017-03-01610.12688/f1000research.10739.111580Recent advances in understanding spondyloarthritis [version 1; referees: 2 approved]J.S.H. Gaston0Department of Medicine, Addenbrooke’s Hospital, Cambridge, UKThis review is concerned with a number of recent publications that contribute to current thinking on the pathogenesis of spondyloarthritis. The areas covered include the lymphocyte population in the enthesis, which is thought to drive enthesitis, and hence clinical manifestations. The debate on how HLA-B27 is implicated in inflammation is also considered, together with recent and contradictory evidence on the effects of the peptide-trimming enzyme ERAP1 on B27 expression and hence susceptibility to spondylitis. Lastly, a recent report on the role of the gut microbiome in an important model of spondyloarthritis is considered.https://f1000research.com/articles/6-304/v1Antigen Processing & RecognitionEnvironmental MicrobiologyGastrointestinal PhysiologyGenetics of the Immune SystemImmune & Inflammatory Rheumatic Diseases (incl. Arthritis)Innate ImmunityLeukocyte Signaling & Gene ExpressionMedical GeneticsMedical Microbiology |
| spellingShingle | J.S.H. Gaston Recent advances in understanding spondyloarthritis [version 1; referees: 2 approved] F1000Research Antigen Processing & Recognition Environmental Microbiology Gastrointestinal Physiology Genetics of the Immune System Immune & Inflammatory Rheumatic Diseases (incl. Arthritis) Innate Immunity Leukocyte Signaling & Gene Expression Medical Genetics Medical Microbiology |
| title | Recent advances in understanding spondyloarthritis [version 1; referees: 2 approved] |
| title_full | Recent advances in understanding spondyloarthritis [version 1; referees: 2 approved] |
| title_fullStr | Recent advances in understanding spondyloarthritis [version 1; referees: 2 approved] |
| title_full_unstemmed | Recent advances in understanding spondyloarthritis [version 1; referees: 2 approved] |
| title_short | Recent advances in understanding spondyloarthritis [version 1; referees: 2 approved] |
| title_sort | recent advances in understanding spondyloarthritis version 1 referees 2 approved |
| topic | Antigen Processing & Recognition Environmental Microbiology Gastrointestinal Physiology Genetics of the Immune System Immune & Inflammatory Rheumatic Diseases (incl. Arthritis) Innate Immunity Leukocyte Signaling & Gene Expression Medical Genetics Medical Microbiology |
| url | https://f1000research.com/articles/6-304/v1 |
| work_keys_str_mv | AT jshgaston recentadvancesinunderstandingspondyloarthritisversion1referees2approved |