Prevalence of latent tuberculosis infection and feasibility of TB preventive therapy among Thai prisoners: a cross-sectional study
Abstract Background Prisons are considered as major reservoirs for tuberculosis. Preventive therapy for latent TB infection (LTBI) is an adjunctive strategy to control TB. However, LTBI data in Thai prisoners is limited. This study assessed the prevalence of LTBI and feasibility of isoniazid prevent...
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | BMC Public Health |
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| Online Access: | https://doi.org/10.1186/s12889-021-11271-0 |
| _version_ | 1818441061696012288 |
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| author | Sivaporn Gatechompol Weerakit Harnpariphan Ruamthip Supanan Gompol Suwanpimolkul Jiratchaya Sophonphan Sasiwimol Ubolyam Stephen J. Kerr Anchalee Avihingsanon Kamon Kawkitinarong |
| author_facet | Sivaporn Gatechompol Weerakit Harnpariphan Ruamthip Supanan Gompol Suwanpimolkul Jiratchaya Sophonphan Sasiwimol Ubolyam Stephen J. Kerr Anchalee Avihingsanon Kamon Kawkitinarong |
| author_sort | Sivaporn Gatechompol |
| collection | DOAJ |
| description | Abstract Background Prisons are considered as major reservoirs for tuberculosis. Preventive therapy for latent TB infection (LTBI) is an adjunctive strategy to control TB. However, LTBI data in Thai prisoners is limited. This study assessed the prevalence of LTBI and feasibility of isoniazid preventive therapy (IPT). Methods A cross-sectional study was conducted among prisoners in Klong Prem Central Prison, Bangkok. Participants were screened for active TB by questionnaire and chest X-ray. LTBI was evaluated by Tuberculin skin test (TST) and QuantiFERON-TB Gold Plus (QFTP) among subgroup. Participants with positive TST or QFTP were considered to have LTBI. Participants with LTBI were offered IPT. Results From August 2018–November 2019, 1002 participants were analyzed. All participants were male with a median age of 38 (IQR 32–50) years. LTBI identified by either TST/QFTP was present in 466 (46.5%) participants. TST was positive in 359 (36%) participants. In the subgroup of 294 participants who had both TST and QFTP results, 181/294 (61.6%) tested positive by QFTP. Agreement between TST and QFTP was 55.1% (Kappa = 0.17). The risk factors associated with LTBI were previous incarceration (aOR 1.53, 95%CI, 1.16–2.01, p = 0.002), history of prior active TB (aOR 3.02, 95%CI, 1.74–5.24, p < 0.001) and duration of incarceration ≥10 years (aOR 1.86, 95%CI, 1.24–2.79, p = 0.003). Majority of LTBI participants (82%) agreed to take IPT. Three hundred and 56 (93%) participants completed treatment whereas 27 (7%) participants discontinued IPT due to the side effects of INH. Conclusion This is the first study to evaluate the prevalence of LTBI and feasibility of IPT among Thai prisoners. LTBI prevalence in male prisoners in Thailand is high. LTBI screening and treatment should be implemented together with other preventive components. |
| first_indexed | 2024-12-14T18:22:16Z |
| format | Article |
| id | doaj.art-6a672bdca6c342f2bd7a4b03a9dca687 |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-12-14T18:22:16Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-6a672bdca6c342f2bd7a4b03a9dca6872022-12-21T22:52:02ZengBMCBMC Public Health1471-24582021-06-012111810.1186/s12889-021-11271-0Prevalence of latent tuberculosis infection and feasibility of TB preventive therapy among Thai prisoners: a cross-sectional studySivaporn Gatechompol0Weerakit Harnpariphan1Ruamthip Supanan2Gompol Suwanpimolkul3Jiratchaya Sophonphan4Sasiwimol Ubolyam5Stephen J. Kerr6Anchalee Avihingsanon7Kamon Kawkitinarong8HIV-NAT, Thai Red Cross AIDS Research CentreMedical Correctional Institution, Bangkok and Klong Prem Central PrisonMedical Correctional Institution, Bangkok and Klong Prem Central PrisonTuberculosis Research Unit, Faculty of Medicine, Chulalongkorn UniversityHIV-NAT, Thai Red Cross AIDS Research CentreHIV-NAT, Thai Red Cross AIDS Research CentreHIV-NAT, Thai Red Cross AIDS Research CentreHIV-NAT, Thai Red Cross AIDS Research CentreTuberculosis Research Unit, Faculty of Medicine, Chulalongkorn UniversityAbstract Background Prisons are considered as major reservoirs for tuberculosis. Preventive therapy for latent TB infection (LTBI) is an adjunctive strategy to control TB. However, LTBI data in Thai prisoners is limited. This study assessed the prevalence of LTBI and feasibility of isoniazid preventive therapy (IPT). Methods A cross-sectional study was conducted among prisoners in Klong Prem Central Prison, Bangkok. Participants were screened for active TB by questionnaire and chest X-ray. LTBI was evaluated by Tuberculin skin test (TST) and QuantiFERON-TB Gold Plus (QFTP) among subgroup. Participants with positive TST or QFTP were considered to have LTBI. Participants with LTBI were offered IPT. Results From August 2018–November 2019, 1002 participants were analyzed. All participants were male with a median age of 38 (IQR 32–50) years. LTBI identified by either TST/QFTP was present in 466 (46.5%) participants. TST was positive in 359 (36%) participants. In the subgroup of 294 participants who had both TST and QFTP results, 181/294 (61.6%) tested positive by QFTP. Agreement between TST and QFTP was 55.1% (Kappa = 0.17). The risk factors associated with LTBI were previous incarceration (aOR 1.53, 95%CI, 1.16–2.01, p = 0.002), history of prior active TB (aOR 3.02, 95%CI, 1.74–5.24, p < 0.001) and duration of incarceration ≥10 years (aOR 1.86, 95%CI, 1.24–2.79, p = 0.003). Majority of LTBI participants (82%) agreed to take IPT. Three hundred and 56 (93%) participants completed treatment whereas 27 (7%) participants discontinued IPT due to the side effects of INH. Conclusion This is the first study to evaluate the prevalence of LTBI and feasibility of IPT among Thai prisoners. LTBI prevalence in male prisoners in Thailand is high. LTBI screening and treatment should be implemented together with other preventive components.https://doi.org/10.1186/s12889-021-11271-0LTBIInmateIsoniazid preventive therapyTSTIGRA |
| spellingShingle | Sivaporn Gatechompol Weerakit Harnpariphan Ruamthip Supanan Gompol Suwanpimolkul Jiratchaya Sophonphan Sasiwimol Ubolyam Stephen J. Kerr Anchalee Avihingsanon Kamon Kawkitinarong Prevalence of latent tuberculosis infection and feasibility of TB preventive therapy among Thai prisoners: a cross-sectional study BMC Public Health LTBI Inmate Isoniazid preventive therapy TST IGRA |
| title | Prevalence of latent tuberculosis infection and feasibility of TB preventive therapy among Thai prisoners: a cross-sectional study |
| title_full | Prevalence of latent tuberculosis infection and feasibility of TB preventive therapy among Thai prisoners: a cross-sectional study |
| title_fullStr | Prevalence of latent tuberculosis infection and feasibility of TB preventive therapy among Thai prisoners: a cross-sectional study |
| title_full_unstemmed | Prevalence of latent tuberculosis infection and feasibility of TB preventive therapy among Thai prisoners: a cross-sectional study |
| title_short | Prevalence of latent tuberculosis infection and feasibility of TB preventive therapy among Thai prisoners: a cross-sectional study |
| title_sort | prevalence of latent tuberculosis infection and feasibility of tb preventive therapy among thai prisoners a cross sectional study |
| topic | LTBI Inmate Isoniazid preventive therapy TST IGRA |
| url | https://doi.org/10.1186/s12889-021-11271-0 |
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